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SLFN11 (NM_001104589) Human Tagged ORF Clone
CAT＃: RC226249
- TrueORF®
SLFN11 (Myc-DDK-tagged)-Human schlafen family member 11 (SLFN11), transcript variant 3
ORF Plasmid: tGFP
"NM_001104589" in other vectors (4)
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CNY 3,990.00
Product images
CNY 300.00
Specifications
| Product Data | |
| Type | Human Tagged ORF Clone |
| Tag | Myc-DDK |
| Synonyms | SLFN8/9 |
| Vector | pCMV6-Entry |
| E. coli Selection | Kanamycin (25 ug/mL) |
| Mammalian Cell Selection | Neomycin |
| Sequence Data |
>RC226249 representing NM_001104589
Red=Cloning site Blue=ORF Green=Tags(s) TTTTGTAATACGACTCACTATAGGGCGGCCGGGAATTCGTCGACTGGATCCGGTACCGAGGAGATCTGCC GCCGCGATCGCC ATGGAGGCAAATCAGTGCCCCCTGGTTGTGGAACCATCTTACCCAGACCTGGTCATCAATGTAGGAGAAG TGACTCTTGGAGAAGAAAACAGAAAAAAGCTGCAGAAAATTCAGAGAGACCAAGAGAAGGAGAGAGTTAT GCGGGCTGCATGTGCTTTATTAAACTCAGGAGGAGGAGTGATTCGAATGGCCAAGAAGGTTGAGCATCCC GTGGAGATGGGACTGGATTTAGAACAGTCTTTGAGAGAGCTTATTCAGTCTTCAGATCTGCAGGCTTTCT TTGAGACCAAGCAACAAGGAAGGTGTTTTTACATTTTTGTTAAATCTTGGAGCAGTGGCCCTTTCCCTGA AGATCGCTCTGTCAAGCCCCGCCTTTGCAGCCTCAGTTCTTCATTATACCGTAGATCTGAGACCTCTGTG CGTTCCATGGACTCAAGAGAGGCATTCTGTTTCCTGAAGACCAAAAGGAAGCCAAAAATCTTGGAAGAAG GACCTTTTCACAAAATTCACAAGGGTGTATACCAAGAGCTCCCTAACTCGGATCCTGCTGACCCAAACTC GGATCCTGCTGACCTAATTTTCCAAAAAGACTATCTTGAATATGGTGAAATCCTGCCTTTTCCTGAGTCT CAGTTAGTAGAGTTTAAACAGTTCTCTACAAAACACTTCCAAGAATATGTAAAAAGGACAATTCCAGAAT ACGTCCCTGCATTTGCAAACACTGGAGGAGGCTATCTTTTTATTGGAGTGGATGATAAGAGTAGGGAAGT CCTGGGATGTGCAAAAGAAAATGTTGACCCTGACTCTTTGAGAAGGAAAATAGAACAAGCCATATACAAA CTACCTTGTGTTCATTTTTGCCAACCCCAACGCCCGATAACCTTCACACTCAAAATTGTGGATGTGTTAA AAAGGGGAGAGCTCTATGGCTATGCTTGCATGATCAGAGTAAATCCCTTCTGCTGTGCAGTGTTCTCAGA AGCTCCCAATTCATGGATAGTGGAGGACAAGTACGTCTGCAGCCTGACAACCGAGAAATGGGTAGGCATG ATGACAGACACAGATCCAGATCTTCTACAGTTGTCTGAAGATTTTGAATGTCAGCTGAGTCTATCTAGTG GGCCTCCCCTTAGCAGACCAGTGTACTCCAAGAAAGGCCTGGAACATAAAAAGGAACTCCAGCAACTTTT ATTTTCAGTCCCACCAGGATATTTGCGATATACTCCAGAGTCACTCTGGAGGGACCTGATCTCAGAGCAC AGAGGACTAGAGGAGTTAATAAATAAGCAAATGCAACCTTTCTTTCGGGGAATTTTGATCTTCTCTAGAA GTTGGGCTGTGGACCTGAACTTGCAGGAGAAGCCAGGAGTCATCTGTGATGCTCTGCTGATAGCACAGAA CAGCACCCCCATTCTCTACACCATTCTCAGGGAGCAGGATGCAGAGGGCCAGGACTACTGCACTCGCACT GCCTTTACTTTGAAGCAGAAGCTAGTGAACATGGGGGGCTACACCGGGAAGGTGTGTGTCAGGGCCAAGG TCCTCTGCCTGAGTCCTGAGAGCAGCGCAGAGGCCTTGGAGGCTGCAGTGTCTCCGATGGATTACCCTGC GTCCTATAGCCTTGCAGGCACCCAGCACATGGAAGCCCTGCTGCAGTCCCTCGTGATTGTCTTACTCGGC TTCAGGTCTCTCTTGAGTGACCAGCTCGGCTGTGAGGTTTTAAATCTGCTCACAGCCCAGCAGTATGAGA TATTCTCCAGAAGCCTCCGCAAGAACAGAGAGTTGTTTGTCCACGGCTTACCTGGCTCAGGGAAGACCAT CATGGCCATGAAGATCATGGAGAAGATCAGGAATGTGTTTCACTGTGAGGCACACAGAATTCTCTACGTT TGTGAAAACCAGCCTCTGAGGAACTTTATCAGTGATAGAAATATCTGCCGAGCAGAGACCCGGAAAACTT TCCTAAGAGAAAACTTTGAACACATTCAACACATCGTCATTGACGAAGCTCAGAATTTCCGTACTGAAGA TGGGGACTGGTATGGGAAGGCAAAAAGCATCACTCGGAGAGCAAAGGGTGGCCCAGGAATTCTCTGGATC TTTCTGGATTACTTTCAGACCAGCCACTTGGATTGCAGTGGCCTCCCTCCTCTCTCAGACCAATATCCAA GAGAAGAGCTCACCAGAATAGTTCGCAATGCAGATCCAATAGCCAAGTACTTACAAAAAGAAATGCAAGT AATTAGAAGTAATCCTTCATTTAACATCCCCACTGGGTGCCTCGAGGTATTTCCTGAAGCCGAATGGTCC CAGGGTGTTCAGGGAACCTTACGAATTAAGAAATACTTGACTGTGGAGCAAATAATGACCTGTGTGGCAG ACACGTGCAGGCGCTTCTTTGATAGGGGCTATTCTCCAAAGGATGTTGCTGTGCTTGTCAGCACCGCAAA AGAAGTGGAGCACTATAAGTATGAGCTCTTGAAAGCAATGAGGAAGAAAAGGGTGGTGCAGCTCAGTGAT GCATGTGATATGTTGGGTGATCACATTGTGTTGGACAGTGTTCGGCGATTCTCAGGCCTGGAAAGGAGCA TAGTGTTTGGGATCCATCCAAGGACAGCTGACCCAGCTATCTTACCCAATGTTCTGATCTGTCTGGCTTC CAGGGCAAAACAACACCTGTATATTTTTCCGTGGGGTGGCCAT ACGCGTACGCGGCCGCTCGAGCAGAAACTCATCTCAGAAGAGGATCTGGCAGCAAATGATATCCTGGATT ACAAGGATGACGACGATAAGGTTTAA >RC226249 representing NM_001104589
Red=Cloning site Green=Tags(s) MEANQCPLVVEPSYPDLVINVGEVTLGEENRKKLQKIQRDQEKERVMRAACALLNSGGGVIRMAKKVEHP VEMGLDLEQSLRELIQSSDLQAFFETKQQGRCFYIFVKSWSSGPFPEDRSVKPRLCSLSSSLYRRSETSV RSMDSREAFCFLKTKRKPKILEEGPFHKIHKGVYQELPNSDPADPNSDPADLIFQKDYLEYGEILPFPES QLVEFKQFSTKHFQEYVKRTIPEYVPAFANTGGGYLFIGVDDKSREVLGCAKENVDPDSLRRKIEQAIYK LPCVHFCQPQRPITFTLKIVDVLKRGELYGYACMIRVNPFCCAVFSEAPNSWIVEDKYVCSLTTEKWVGM MTDTDPDLLQLSEDFECQLSLSSGPPLSRPVYSKKGLEHKKELQQLLFSVPPGYLRYTPESLWRDLISEH RGLEELINKQMQPFFRGILIFSRSWAVDLNLQEKPGVICDALLIAQNSTPILYTILREQDAEGQDYCTRT AFTLKQKLVNMGGYTGKVCVRAKVLCLSPESSAEALEAAVSPMDYPASYSLAGTQHMEALLQSLVIVLLG FRSLLSDQLGCEVLNLLTAQQYEIFSRSLRKNRELFVHGLPGSGKTIMAMKIMEKIRNVFHCEAHRILYV CENQPLRNFISDRNICRAETRKTFLRENFEHIQHIVIDEAQNFRTEDGDWYGKAKSITRRAKGGPGILWI FLDYFQTSHLDCSGLPPLSDQYPREELTRIVRNADPIAKYLQKEMQVIRSNPSFNIPTGCLEVFPEAEWS QGVQGTLRIKKYLTVEQIMTCVADTCRRFFDRGYSPKDVAVLVSTAKEVEHYKYELLKAMRKKRVVQLSD ACDMLGDHIVLDSVRRFSGLERSIVFGIHPRTADPAILPNVLICLASRAKQHLYIFPWGGH TRTRPLEQKLISEEDLAANDILDYKDDDDKV |
| Restriction Sites |
SgfI-MluI
Cloning Scheme for this gene
Plasmid Map
|
| ACCN | NM_001104589 |
| ORF Size | 2703 bp |
| OTI Disclaimer | The molecular sequence of this clone aligns with the gene accession number as a point of reference only. However, individual transcript sequences of the same gene can differ through naturally occurring variations (e.g. polymorphisms), each with its own valid existence. This clone is substantially in agreement with the reference, but a complete review of all prevailing variants is recommended prior to use. More info |
| OTI Annotation | This clone was engineered to express the complete ORF with an expression tag. Expression varies depending on the nature of the gene. |
| Product Components | The ORF clone is ion-exchange column purified and shipped in a 2D barcoded Matrix tube containing 10ug of transfection-ready, dried plasmid DNA (reconstitute with 100 ul of water). |
| Reconstitution | 1. Centrifuge at 5,000xg for 5min. 2. Carefully open the tube and add 100ul of sterile water to dissolve the DNA. 3. Close the tube and incubate for 10 minutes at room temperature. 4. Briefly vortex the tube and then do a quick spin (less than 5000xg) to concentrate the liquid at the bottom. 5. Store the suspended plasmid at -20°C. The DNA is stable for at least one year from date of shipping when stored at -20°C. |
| Reference Data | |
| RefSeq | NM_001104589.1, NP_001098059.1 |
| RefSeq ORF | 2706 bp |
| Locus ID | 91607 |
| UniProt ID | Q7Z7L1 |
| MW | 102.7 kDa |
| Gene Summary | Inhibitor of DNA replication that promotes cell death in response to DNA damage (PubMed:22927417, PubMed:26658330, PubMed:29395061). Acts as a guardian of the genome by killing cells with defective replication (PubMed:29395061). Persistently blocks stressed replication forks by opening chromatin across replication initiation sites at stressed replication forks, possibly leading to unwind DNA ahead of the MCM helicase and block fork progression, ultimately leading to cell death (PubMed:29395061). Acts independently of ATR (PubMed:29395061). Also acts as an interferon (IFN)-induced antiviral protein which acts as an inhibitor of retrovirus protein synthesis (PubMed:23000900). Specifically abrogates the production of retroviruses such as human immunodeficiency virus 1 (HIV-1) by acting as a specific inhibitor of the synthesis of retroviruses encoded proteins in a codon-usage-dependent manner (PubMed:23000900). Binds to tRNAs and exploits the unique viral codon bias towards A/T nucleotides (PubMed:23000900). The exact inhibition mechanism is unclear: may either sequester tRNAs, prevent their maturation via post-transcriptional processing or may accelerate their deacylation (PubMed:23000900). Does not inhibit reverse transcription, integration or production and nuclear export of viral RNA (PubMed:23000900).[UniProtKB/Swiss-Prot Function] |
Documents
| Product Manuals |
| FAQs |
| SDS |
Resources
Other Versions
| SKU | Description | Size | Price |
|---|---|---|---|
| RC226249L3 | Lenti-ORF clone of SLFN11 (Myc-DDK-tagged)-Human schlafen family member 11 (SLFN11), transcript variant 3 |
CNY 5,890.00 |
|
| RC226249L4 | Lenti-ORF clone of SLFN11 (mGFP-tagged)-Human schlafen family member 11 (SLFN11), transcript variant 3 |
CNY 5,890.00 |
|
| RG226249 | SLFN11 (tGFP-tagged) - Human schlafen family member 11 (SLFN11), transcript variant 3 |
CNY 4,370.00 |
|
| SC317147 | SLFN11 (untagged)-Human schlafen family member 11 (SLFN11), transcript variant 3 |
CNY 7,220.00 |
