ACE2 (NM_021804) Human Tagged ORF Clone (Angiotensin Converting Enzyme 2)
CAT#: RC208442
- TrueORF®
ACE2 (Myc-DDK-tagged)-Human angiotensin I converting enzyme (peptidyl-dipeptidase A) 2 (ACE2)
ORF Plasmid: tGFP
"NM_021804" in other vectors (6)
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CNY 5,896.00
Cited in 16 publications. |
CNY 300.00
CNY 1,999.00
CNY 2,700.00
Specifications
Product Data | |
Type | Human Tagged ORF Clone |
Tag | Myc-DDK |
Synonyms | ACEH |
Vector | pCMV6-Entry |
E. coli Selection | Kanamycin (25 ug/mL) |
Mammalian Cell Selection | Neomycin |
Sequence Data |
>RC208442 representing NM_021804.
Blue=ORF Red=Cloning site Green=Tag(s) GCTCGTTTAGTGAACCGTCAGAATTTTGTAATACGACTCACTATAGGGCGGCCGGGAATTCGTCGACTG GATCCGGTACCGAGGAGATCTGCCGCCGCGATCGCC ATGTCAAGCTCTTCCTGGCTCCTTCTCAGCCTTGTTGCTGTAACTGCTGCTCAGTCCACCATTGAGGAA CAGGCCAAGACATTTTTGGACAAGTTTAACCACGAAGCCGAAGACCTGTTCTATCAAAGTTCACTTGCT TCTTGGAATTATAACACCAATATTACTGAAGAGAATGTCCAAAACATGAATAATGCTGGGGACAAATGG TCTGCCTTTTTAAAGGAACAGTCCACACTTGCCCAAATGTATCCACTACAAGAAATTCAGAATCTCACA GTCAAGCTTCAGCTGCAGGCTCTTCAGCAAAATGGGTCTTCAGTGCTCTCAGAAGACAAGAGCAAACGG TTGAACACAATTCTAAATACAATGAGCACCATCTACAGTACTGGAAAAGTTTGTAACCCAGATAATCCA CAAGAATGCTTATTACTTGAACCAGGTTTGAATGAAATAATGGCAAACAGTTTAGACTACAATGAGAGG CTCTGGGCTTGGGAAAGCTGGAGATCTGAGGTCGGCAAGCAGCTGAGGCCATTATATGAAGAGTATGTG GTCTTGAAAAATGAGATGGCAAGAGCAAATCATTATGAGGACTATGGGGATTATTGGAGAGGAGACTAT GAAGTAAATGGGGTAGATGGCTATGACTACAGCCGCGGCCAGTTGATTGAAGATGTGGAACATACCTTT GAAGAGATTAAACCATTATATGAACATCTTCATGCCTATGTGAGGGCAAAGTTGATGAATGCCTATCCT TCCTATATCAGTCCAATTGGATGCCTCCCTGCTCATTTGCTTGGTGATATGTGGGGTAGATTTTGGACA AATCTGTACTCTTTGACAGTTCCCTTTGGACAGAAACCAAACATAGATGTTACTGATGCAATGGTGGAC CAGGCCTGGGATGCACAGAGAATATTCAAGGAGGCCGAGAAGTTCTTTGTATCTGTTGGTCTTCCTAAT ATGACTCAAGGATTCTGGGAAAATTCCATGCTAACGGACCCAGGAAATGTTCAGAAAGCAGTCTGCCAT CCCACAGCTTGGGACCTGGGGAAGGGCGACTTCAGGATCCTTATGTGCACAAAGGTGACAATGGACGAC TTCCTGACAGCTCATCATGAGATGGGGCATATCCAGTATGATATGGCATATGCTGCACAACCTTTTCTG CTAAGAAATGGAGCTAATGAAGGATTCCATGAAGCTGTTGGGGAAATCATGTCACTTTCTGCAGCCACA CCTAAGCATTTAAAATCCATTGGTCTTCTGTCACCCGATTTTCAAGAAGACAATGAAACAGAAATAAAC TTCCTGCTCAAACAAGCACTCACGATTGTTGGGACTCTGCCATTTACTTACATGTTAGAGAAGTGGAGG TGGATGGTCTTTAAAGGGGAAATTCCCAAAGACCAGTGGATGAAAAAGTGGTGGGAGATGAAGCGAGAG ATAGTTGGGGTGGTGGAACCTGTGCCCCATGATGAAACATACTGTGACCCCGCATCTCTGTTCCATGTT TCTAATGATTACTCATTCATTCGATATTACACAAGGACCCTTTACCAATTCCAGTTTCAAGAAGCACTT TGTCAAGCAGCTAAACATGAAGGCCCTCTGCACAAATGTGACATCTCAAACTCTACAGAAGCTGGACAG AAACTGTTCAATATGCTGAGGCTTGGAAAATCAGAACCCTGGACCCTAGCATTGGAAAATGTTGTAGGA GCAAAGAACATGAATGTAAGGCCACTGCTCAACTACTTTGAGCCCTTATTTACCTGGCTGAAAGACCAG AACAAGAATTCTTTTGTGGGATGGAGTACCGACTGGAGTCCATATGCAGACCAAAGCATCAAAGTGAGG ATAAGCCTAAAATCAGCTCTTGGAGATAAAGCATATGAATGGAACGACAATGAAATGTACCTGTTCCGA TCATCTGTTGCATATGCTATGAGGCAGTACTTTTTAAAAGTAAAAAATCAGATGATTCTTTTTGGGGAG GAGGATGTGCGAGTGGCTAATTTGAAACCAAGAATCTCCTTTAATTTCTTTGTCACTGCACCTAAAAAT GTGTCTGATATCATTCCTAGAACTGAAGTTGAAAAGGCCATCAGGATGTCCCGGAGCCGTATCAATGAT GCTTTCCGTCTGAATGACAACAGCCTAGAGTTTCTGGGGATACAGCCAACACTTGGACCTCCTAACCAG CCCCCTGTTTCCATATGGCTGATTGTTTTTGGAGTTGTGATGGGAGTGATAGTGGTTGGCATTGTCATC CTGATCTTCACTGGGATCAGAGATCGGAAGAAGAAAAATAAAGCAAGAAGTGGAGAAAATCCTTATGCC TCCATCGATATTAGCAAAGGAGAAAATAATCCAGGATTCCAAAACACTGATGATGTTCAGACCTCCTTT ACGCGTACGCGGCCGCTCGAGCAGAAACTCATCTCAGAAGAGGATCTGGCAGCAAATGATATCCTGGAT TACAAGGATGACGACGATAAGGTTTAAACGGCCGGC >Peptide sequence encoded by RC208442
Blue=ORF Red=Cloning site Green=Tag(s) MSSSSWLLLSLVAVTAAQSTIEEQAKTFLDKFNHEAEDLFYQSSLASWNYNTNITEENVQNMNNAGDKW SAFLKEQSTLAQMYPLQEIQNLTVKLQLQALQQNGSSVLSEDKSKRLNTILNTMSTIYSTGKVCNPDNP QECLLLEPGLNEIMANSLDYNERLWAWESWRSEVGKQLRPLYEEYVVLKNEMARANHYEDYGDYWRGDY EVNGVDGYDYSRGQLIEDVEHTFEEIKPLYEHLHAYVRAKLMNAYPSYISPIGCLPAHLLGDMWGRFWT NLYSLTVPFGQKPNIDVTDAMVDQAWDAQRIFKEAEKFFVSVGLPNMTQGFWENSMLTDPGNVQKAVCH PTAWDLGKGDFRILMCTKVTMDDFLTAHHEMGHIQYDMAYAAQPFLLRNGANEGFHEAVGEIMSLSAAT PKHLKSIGLLSPDFQEDNETEINFLLKQALTIVGTLPFTYMLEKWRWMVFKGEIPKDQWMKKWWEMKRE IVGVVEPVPHDETYCDPASLFHVSNDYSFIRYYTRTLYQFQFQEALCQAAKHEGPLHKCDISNSTEAGQ KLFNMLRLGKSEPWTLALENVVGAKNMNVRPLLNYFEPLFTWLKDQNKNSFVGWSTDWSPYADQSIKVR ISLKSALGDKAYEWNDNEMYLFRSSVAYAMRQYFLKVKNQMILFGEEDVRVANLKPRISFNFFVTAPKN VSDIIPRTEVEKAIRMSRSRINDAFRLNDNSLEFLGIQPTLGPPNQPPVSIWLIVFGVVMGVIVVGIVI LIFTGIRDRKKKNKARSGENPYASIDISKGENNPGFQNTDDVQTSF TRTRPLEQKLISEEDLAANDILDYKDDDDKV |
Chromatograms |
CHROMATOGRAMS
Sequencher program is needed, download here. |
Restriction Sites | SgfI-MluI Cloning Scheme for this gene Plasmid Map |
ACCN | NM_021804 |
ORF Size | 2415 bp |
OTI Disclaimer | The molecular sequence of this clone aligns with the gene accession number as a point of reference only. However, individual transcript sequences of the same gene can differ through naturally occurring variations (e.g. polymorphisms), each with its own valid existence. This clone is substantially in agreement with the reference, but a complete review of all prevailing variants is recommended prior to use. More info |
OTI Annotation | This clone was engineered to express the complete ORF with an expression tag. Expression varies depending on the nature of the gene. |
Product Components | The ORF clone is ion-exchange column purified and shipped in a 2D barcoded Matrix tube containing 10ug of transfection-ready, dried plasmid DNA (reconstitute with 100 ul of water). |
Reconstitution | 1. Centrifuge at 5,000xg for 5min. 2. Carefully open the tube and add 100ul of sterile water to dissolve the DNA. 3. Close the tube and incubate for 10 minutes at room temperature. 4. Briefly vortex the tube and then do a quick spin (less than 5000xg) to concentrate the liquid at the bottom. 5. Store the suspended plasmid at -20°C. The DNA is stable for at least one year from date of shipping when stored at -20°C. |
Reference Data | |
RefSeq | NM_021804.3 |
RefSeq Size | 3519 bp |
RefSeq ORF | 2418 bp |
Locus ID | 59272 |
UniProt ID | Q9BYF1 |
Protein Families | Druggable Genome, Secreted Protein, Transmembrane |
Protein Pathways | Renin-angiotensin system |
MW | 92.5 kDa |
Gene Summary | The protein encoded by this gene belongs to the angiotensin-converting enzyme family of dipeptidyl carboxydipeptidases and has considerable homology to human angiotensin 1 converting enzyme. This secreted protein catalyzes the cleavage of angiotensin I into angiotensin 1-9, and angiotensin II into the vasodilator angiotensin 1-7. ACE2 is known to be expressed in various human organs, and its organ- and cell-specific expression suggests that it may play a role in the regulation of cardiovascular and renal function, as well as fertility. In addition, the encoded protein is a functional receptor for the spike glycoprotein of the human coronavirus HCoV-NL63 and the human severe acute respiratory syndrome coronaviruses, SARS-CoV and SARS-CoV-2, the latter is the causative agent of coronavirus disease-2019 (COVID-19). Multiple splice variants have been found for this gene and the dACE2 (or MIRb-ACE2) splice variant has been found to be interferon inducible. [provided by RefSeq, Nov 2020] |
Citations (16)
The use of this cDNA Clones has been cited in the following citations: |
---|
Characterization of ACE2 naturally occurring missense variants: impact on subcellular localization and trafficking
,null,
Human Genomics
,PubMed ID 36056420
[ACE2]
|
Mild respiratory COVID can cause multi-lineage neural cell and myelin dysregulation
,null,
Cell
,PubMed ID 35768006
[ACE2]
|
Poloxamer-188 Adjuvant Efficiently Maintains Adaptive Immunity of SARS-CoV-2 RBD Subunit Vaccination through Repressing p38MAPK Signaling
,null,
Vaccines
,PubMed ID 35632471
[ACE2]
|
SARS-COV-2 recombinant Receptor-Binding-Domain (RBD) induces neutralizing antibodies against variant strains of SARS-CoV-2 and SARS-CoV-1
,null,
Vaccine
,PubMed ID 34481699
[ACE2]
|
Antibody isotype diversity against SARS-CoV-2 is associated with differential serum neutralization capacities
,Noval, MG;Kaczmarek, ME;Koide, A;Rodriguez-Rodriguez, BA;Louie, P;Tada, T;Hattori, T;Panchenko, T;Romero, LA;Teng, KW;Bazley, A;de Vries, M;Samanovic, MI;Weiser, JN;Aifantis, I;Cangiarella, J;Mulligan, MJ;Desvignes, L;Dittmann, M;Landau, NR;Aguero-Rosenfeld, M;Koide, S;Stapleford, KA;,
Scientific reports
,PubMed ID 33692390
[ACE2]
|
Interferons and viruses induce a novel truncated ACE2 isoform and not the full-length SARS-CoV-2 receptor
,Onabajo, OO;Banday, AR;Stanifer, ML;Yan, W;Obajemu, A;Santer, DM;Florez-Vargas, O;Piontkivska, H;Vargas, JM;Ring, TJ;Kee, C;Doldan, P;Tyrrell, DL;Mendoza, JL;Boulant, S;Prokunina-Olsson, L;,
Nat Genet
,PubMed ID 33077916
[ACE2]
|
A Soluble ACE2 Microbody Protein Fused to a Single Immunoglobulin Fc Domain is a Potent Inhibitor of SARS-CoV-2 Infection
,Tada, T;Fan, C;Kaur, R;Stapleford, K;Gristick, H;Nimigean, C;Landau, N;,
SSRN Journal
[ACE2]
|
High Potency of a Bivalent Human VH Domain in SARS-CoV-2 Animal Models
,Li, W;Schäfer, A;Kulkarni, SS;Liu, X;Martinez, DR;Chen, C;Sun, Z;Leist, SR;Drelich, A;Zhang, L;Ura, ML;Berezuk, A;Chittori, S;Leopold, K;Mannar, D;Srivastava, SS;Zhu, X;Peterson, EC;Tseng, CT;Mellors, JW;Falzarano, D;Subramaniam, S;Baric, RS;Dimitrov, DS;,
Cell
,PubMed ID 32941803
[ACE2]
|
Enhanced elicitation of potent neutralizing antibodies by the SARS-CoV-2 spike receptor binding domain Fc fusion protein in mice
,Liu, X;Drelich, A;Li, W;Chen, C;Sun, Z;Shi, M;Adams, C;Mellors, J;Tseng, C;Dimitrov, D;,
Vaccine
,PubMed ID 33010978
[ACE2]
|
The Actin Bundling Protein Fascin-1 as an ACE2-Accessory Protein
,Ogunlade, B;Guidry, JJ;Mukerjee, S;Sriramula, S;Lazartigues, E;Filipeanu, CM;,
Cell. Mol. Neurobiol.
,PubMed ID 32865675
[ACE2]
|
Interferons and viruses induce a novel primate-specific isoform dACE2 and not the SARS-CoV-2 receptor ACE2
,null,
bioRxiv
,PubMed ID 32743577
[ACE2]
|
Interferons and viruses induce a novel primate-specific isoform dACE2 and not the SARS-CoV-2 receptor ACE2
,Onabajo, O;Banday, A;Yan, W;Obajemu, A;Stanifer, M;Santer, D;Florez-Vargas, O;Piontkivska, H;Vargas, J;Kee, C;Tyrrell, D;Mendoza, J;Boulant, S;Prokunina-Olsson, L;,
bioRxiv
[ACE2]
|
Potent neutralization of SARS-CoV-2 by human antibody heavy-chain variable domains isolated from a large library with a new stable scaffold
,Sun, Z;Chen, C;Li, W;Martinez, DR;Drelich, A;Baek, DS;Liu, X;Mellors, JW;Tseng, CT;Baric, RS;Dimitrov, DS;,
MAbs
,PubMed ID 32544372
[ACE2]
|
Identification of residues controlling restriction versus enhancing activities of IFITM proteins on the entry of human coronaviruses
,Zhao, X;Sehgal, M;Hou, Z;Cheng, J;Shu, S;Wu, S;Guo, F;Le Marchand, SJ;Lin, H;Chang, J;Guo, JT;,
J. Virol.
,PubMed ID 29263263
[ACE2]
|
microRNA-1246 mediates lipopolysaccharide-induced pulmonary endothelial cell apoptosis and acute lung injury by targeting angiotensin-converting enzyme 2
,Fang, Y;Gao, F;Hao, J;Liu, Z;,
Am J Transl Res
,PubMed ID 28386354
[ACE2]
|
Inhibition of ER glucosidases impairs SARS-CoV and HCoV-NL63 spike protein-mediated entry by altering the glycan processing of ACE2
,Zhao, X;Guo, F;Comunale, MA;Mehta, A;Sehgal, M;Jain, P;Cuconati, A;Lin, H;Block, TM;Chang, J;Guo, JT;,
Antimicrob. Agents Chemother.
,PubMed ID 25348530
[ACE2]
|
Documents
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Resources
Other Versions
SKU | Description | Size | Price |
---|---|---|---|
RC208442L1 | Lenti ORF clone of Human angiotensin I converting enzyme (peptidyl-dipeptidase A) 2 (ACE2), Myc-DDK-tagged |
CNY 8,296.00 |
|
RC208442L2 | Lenti ORF clone of Human angiotensin I converting enzyme (peptidyl-dipeptidase A) 2 (ACE2), mGFP tagged |
CNY 8,296.00 |
|
RC208442L3 | Lenti ORF clone of Human angiotensin I converting enzyme (peptidyl-dipeptidase A) 2 (ACE2), Myc-DDK-tagged |
CNY 8,296.00 |
|
RC208442L4 | Lenti ORF clone of Human angiotensin I converting enzyme (peptidyl-dipeptidase A) 2 (ACE2), mGFP tagged |
CNY 8,296.00 |
|
RG208442 | ACE2 (tGFP-tagged) - Human angiotensin I converting enzyme (peptidyl-dipeptidase A) 2 (ACE2) |
CNY 7,496.00 |
|
SC124099 | ACE2 (untagged)-Human angiotensin I converting enzyme (peptidyl-dipeptidase A) 2 (ACE2) |
CNY 8,856.00 |
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