MX2 (NM_002463) Human Tagged ORF Clone
CAT#: RC206437
MX2 (Myc-DDK-tagged)-Human myxovirus (influenza virus) resistance 2 (mouse) (MX2)
ORF Plasmid: tGFP
"NM_002463" in other vectors (6)
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CNY 7,856.00
Cited in 3 publications. |
CNY 300.00
Specifications
Product Data | |
Type | Human Tagged ORF Clone |
Tag | Myc-DDK |
Synonyms | MXB |
Vector | pCMV6-Entry |
E. coli Selection | Kanamycin (25 ug/mL) |
Mammalian Cell Selection | Neomycin |
Sequence Data |
>RC206437 ORF sequence
Red=Cloning site Blue=ORF Green=Tags(s) TTTTGTAATACGACTCACTATAGGGCGGCCGGGAATTCGTCGACTGGATCCGGTACCGAGGAGATCTGCC GCCGCGATCGCC ATGTCTAAGGCCCACAAGCCTTGGCCCTACCGGAGGAGAAGTCAATTTTCTTCTCGAAAATACCTGAAAA AAGAAATGAATTCCTTCCAGCAACAGCCACCGCCATTCGGCACAGTGCCACCACAAATGATGTTTCCTCC AAACTGGCAGGGGGCAGAGAAGGACGCTGCTTTCCTCGCCAAGGACTTCAACTTTCTCACTTTGAACAAT CAGCCACCACCAGGAAACAGGAGCCAACCAAGGGCAATGGGGCCCGAGAACAACCTGTACAGCCAGTACG AGCAGAAGGTGCGCCCCTGCATTGACCTCATCGACTCCCTGCGGGCTCTGGGTGTGGAGCAGGACCTGGC CCTGCCAGCCATCGCCGTCATCGGGGACCAGAGCTCGGGCAAGAGCTCTGTGCTGGAGGCACTGTCAGGA GTCGCGCTTCCCAGAGGCAGCGGAATCGTAACCAGGTGTCCGCTGGTGCTGAAACTGAAAAAGCAGCCCT GTGAGGCATGGGCCGGAAGGATCAGCTACCGGAACACCGAGCTAGAGCTTCAGGACCCTGGCCAGGTGGA GAAAGAGATACACAAAGCCCAGAACGTCATGGCCGGGAATGGCCGGGGCATCAGCCATGAGCTCATCAGC CTGGAGATCACCTCCCCTGAGGTTCCAGACCTGACCATCATTGACCTTCCCGGCATCACCAGGGTGGCTG TGGACAACCAGCCCCGAGACATCGGACTGCAGATCAAGGCTCTCATCAAGAAGTACATCCAGAGGCAGCA GACGATCAACTTGGTGGTGGTTCCCTGTAACGTGGACATTGCCACCACGGAGGCGCTGAGCATGGCCCAT GAGGTGGACCCGGAAGGGGACAGGACCATCGGTATCCTGACCAAACCAGATCTAATGGACAGGGGCACTG AGAAAAGCGTCATGAATGTGGTGCGGAACCTCACGTACCCCCTCAAGAAGGGCTACATGATTGTGAAGTG CCGGGGCCAGCAGGAGATCACAAACAGGCTGAGCTTGGCAGAGGCAACCAAGAAAGAAATTACATTCTTT CAAACACATCCATATTTCAGAGTTCTCCTGGAGGAGGGGTCAGCCACGGTTCCCCGACTGGCAGAAAGAC TTACCACTGAACTCATCATGCATATCCAAAAATCGCTCCCGTTGTTAGAAGGACAAATAAGGGAGAGCCA CCAGAAGGCGACCGAGGAGCTGCGGCGTTGCGGGGCTGACATCCCCAGCCAGGAGGCCGACAAGATGTTC TTTCTAATTGAGAAAATCAAGATGTTTAATCAGGACATCGAAAAGTTAGTAGAAGGAGAAGAAGTTGTAA GGGAGAATGAGACCCGTTTATACAACAAAATCAGAGAGGATTTTAAAAACTGGGTAGGCATACTTGCAAC TAATACCCAAAAAGTTAAAAATATTATCCACGAAGAAGTTGAAAAATATGAAAAGCAGTATCGAGGCAAG GAGCTTCTGGGATTTGTCAACTACAAGACATTTGAGATCATCGTGCATCAGTACATCCAGCAGCTGGTGG AGCCCGCCCTTAGCATGCTCCAGAAAGCCATGGAAATTATCCAGCAAGCTTTCATTAACGTGGCCAAAAA ACATTTTGGCGAATTTTTCAACCTTAACCAAACTGTTCAGAGCACGATTGAAGACATAAAAGTGAAACAC ACAGCAAAGGCAGAAAACATGATCCAACTTCAGTTCAGAATGGAGCAGATGGTTTTTTGTCAAGATCAGA TTTACAGTGTTGTTCTGAAGAAAGTCCGAGAAGAGATTTTTAACCCTCTGGGGACGCCTTCACAGAATAT GAAGTTGAACTCTCATTTTCCCAGTAATGAGTCTTCGGTTTCCTCCTTTACTGAAATAGGCATCCACCTG AATGCCTACTTCTTGGAAACCAGCAAACGTCTCGCCAACCAGATCCCATTTATAATTCAGTATTTTATGC TCCGAGAGAATGGTGACTCCTTGCAGAAAGCCATGATGCAGATACTACAGGAAAAAAATCGCTATTCCTG GCTGCTTCAAGAGCAGAGTGAGACCGCTACCAAGAGAAGAATCCTTAAGGAGAGAATTTACCGGCTCACT CAGGCGCGACACGCACTCTGTCAATTCTCCAGCAAAGAGATCCAC ACGCGTACGCGGCCGCTCGAGCAGAAACTCATCTCAGAAGAGGATCTGGCAGCAAATGATATCCTGGATT ACAAGGATGACGACGATAAGGTTTAA >RC206437 protein sequence
Red=Cloning site Green=Tags(s) MSKAHKPWPYRRRSQFSSRKYLKKEMNSFQQQPPPFGTVPPQMMFPPNWQGAEKDAAFLAKDFNFLTLNN QPPPGNRSQPRAMGPENNLYSQYEQKVRPCIDLIDSLRALGVEQDLALPAIAVIGDQSSGKSSVLEALSG VALPRGSGIVTRCPLVLKLKKQPCEAWAGRISYRNTELELQDPGQVEKEIHKAQNVMAGNGRGISHELIS LEITSPEVPDLTIIDLPGITRVAVDNQPRDIGLQIKALIKKYIQRQQTINLVVVPCNVDIATTEALSMAH EVDPEGDRTIGILTKPDLMDRGTEKSVMNVVRNLTYPLKKGYMIVKCRGQQEITNRLSLAEATKKEITFF QTHPYFRVLLEEGSATVPRLAERLTTELIMHIQKSLPLLEGQIRESHQKATEELRRCGADIPSQEADKMF FLIEKIKMFNQDIEKLVEGEEVVRENETRLYNKIREDFKNWVGILATNTQKVKNIIHEEVEKYEKQYRGK ELLGFVNYKTFEIIVHQYIQQLVEPALSMLQKAMEIIQQAFINVAKKHFGEFFNLNQTVQSTIEDIKVKH TAKAENMIQLQFRMEQMVFCQDQIYSVVLKKVREEIFNPLGTPSQNMKLNSHFPSNESSVSSFTEIGIHL NAYFLETSKRLANQIPFIIQYFMLRENGDSLQKAMMQILQEKNRYSWLLQEQSETATKRRILKERIYRLT QARHALCQFSSKEIH TRTRPLEQKLISEEDLAANDILDYKDDDDKV |
Chromatograms |
CHROMATOGRAMS
![]() Sequencher program is needed, download here. |
Restriction Sites |
SgfI-MluI
Cloning Scheme for this gene
Plasmid Map
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ACCN | NM_002463 |
ORF Size | 2145 bp |
OTI Disclaimer | Due to the inherent nature of this plasmid, standard methods to replicate additional amounts of DNA in E. coli are highly likely to result in mutations and/or rearrangements. Therefore, OriGene does not guarantee the capability to replicate this plasmid DNA. Additional amounts of DNA can be purchased from OriGene with batch-specific, full-sequence verification at a reduced cost. Please contact our customer care team at custsupport@origene.com or by calling 301.340.3188 option 3 for pricing and delivery. The molecular sequence of this clone aligns with the gene accession number as a point of reference only. However, individual transcript sequences of the same gene can differ through naturally occurring variations (e.g. polymorphisms), each with its own valid existence. This clone is substantially in agreement with the reference, but a complete review of all prevailing variants is recommended prior to use. More info |
OTI Annotation | This clone was engineered to express the complete ORF with an expression tag. Expression varies depending on the nature of the gene. |
Product Components | The ORF clone is ion-exchange column purified and shipped in a 2D barcoded Matrix tube containing 10ug of transfection-ready, dried plasmid DNA (reconstitute with 100 ul of water). |
Reconstitution | 1. Centrifuge at 5,000xg for 5min. 2. Carefully open the tube and add 100ul of sterile water to dissolve the DNA. 3. Close the tube and incubate for 10 minutes at room temperature. 4. Briefly vortex the tube and then do a quick spin (less than 5000xg) to concentrate the liquid at the bottom. 5. Store the suspended plasmid at -20°C. The DNA is stable for at least one year from date of shipping when stored at -20°C. |
Reference Data | |
RefSeq | NM_002463.2 |
RefSeq Size | 2961 bp |
RefSeq ORF | 2148 bp |
Locus ID | 4600 |
UniProt ID | P20592 |
Domains | dynamin_2, dynamin, GED |
Protein Families | Druggable Genome |
MW | 82.1 kDa |
Gene Summary | The protein encoded by this gene has a nuclear and a cytoplasmic form and is a member of both the dynamin family and the family of large GTPases. The nuclear form is localized in a granular pattern in the heterochromatin region beneath the nuclear envelope. A nuclear localization signal (NLS) is present at the amino terminal end of the nuclear form but is lacking in the cytoplasmic form due to use of an alternate translation start codon. This protein is upregulated by interferon-alpha but does not contain the antiviral activity of a similar myxovirus resistance protein 1. [provided by RefSeq, Jul 2008] |
Citations (3)
The use of this cDNA Clones has been cited in the following citations: |
---|
Massively parallel reporter assays of melanoma risk variants identify MX2 as a gene promoting melanoma
,Choi, J;Zhang, T;Vu, A;Ablain, J;Makowski, MM;Colli, LM;Xu, M;Hennessey, RC;Yin, J;Rothschild, H;Gräwe, C;Kovacs, MA;Funderburk, KM;Brossard, M;Taylor, J;Pasaniuc, B;Chari, R;Chanock, SJ;Hoggart, CJ;Demenais, F;Barrett, JH;Law, MH;Iles, MM;Yu, K;Vermeulen, M;Zon, LI;Brown, KM;,
Nat Commun
,PubMed ID 32483191
[MX2]
|
Massively parallel reporter assays combined with cell-type specific eQTL informed multiple melanoma loci and identified a pleiotropic function of HIV-1 restriction gene, MX2, in melanoma promotion
,Choi, J;Zhang, T;Vu, A;Ablain, J;Makowski, MM;,
BioRxiv
[MX2]
|
Naturally Occurring Mutations in HIV-1 CRF01_AE Capsid Affect Viral Sensitivity to Restriction Factors
,Nakayama, EE;Saito, A;Sultana, T;Jin, Z;Nohata, K;Shibata, M;Hosoi, M;Motomura, K;Shioda, T;Sangkitporn, S;Loket, R;Saeng-Aroon, S;,
AIDS Res. Hum. Retroviruses
,PubMed ID 29325426
[MX2]
|
Documents
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SDS |
Resources
Other Versions
SKU | Description | Size | Price |
---|---|---|---|
RC206437L1 | Lenti ORF clone of Human myxovirus (influenza virus) resistance 2 (mouse) (MX2), Myc-DDK-tagged |
CNY 10,256.00 |
|
RC206437L2 | Lenti ORF clone of Human myxovirus (influenza virus) resistance 2 (mouse) (MX2), mGFP tagged |
CNY 5,890.00 |
|
RC206437L3 | Lenti ORF clone of Human myxovirus (influenza virus) resistance 2 (mouse) (MX2), Myc-DDK-tagged |
CNY 5,890.00 |
|
RC206437L4 | Lenti ORF clone of Human myxovirus (influenza virus) resistance 2 (mouse) (MX2), mGFP tagged |
CNY 10,256.00 |
|
RG206437 | MX2 (tGFP-tagged) - Human myxovirus (influenza virus) resistance 2 (mouse) (MX2) |
CNY 4,370.00 |
|
SC127459 | MX2 (untagged)-Human myxovirus (influenza virus) resistance 2 (mouse) (MX2) |
CNY 7,864.00 |