CLC7 (CLCN7) (NM_001287) Human Tagged ORF Clone
CAT#: RC203450
CLCN7 (Myc-DDK-tagged)-Human chloride channel 7 (CLCN7), transcript variant 1
ORF Plasmid: tGFP
"NM_001287" in other vectors (7)
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CNY 8,840.00
Cited in 2 publications. |
CNY 300.00
Specifications
Product Data | |
Type | Human Tagged ORF Clone |
Tag | Myc-DDK |
Synonyms | CLC-7; CLC7; HOD; OPTA2; OPTB4; PPP1R63 |
Vector | pCMV6-Entry |
E. coli Selection | Kanamycin (25 ug/mL) |
Mammalian Cell Selection | Neomycin |
Sequence Data |
>RC203450 ORF sequence
Red=Cloning site Blue=ORF Green=Tags(s) TTTTGTAATACGACTCACTATAGGGCGGCCGGGAATTCGTCGACTGGATCCGGTACCGAGGAGATCTGCC GCCGCGATCGCC ATGGCCAACGTCTCTAAGAAGGTGTCCTGGTCCGGCCGGGACCGGGACGACGAGGAGGCGGCGCCGCTGC TGCGGAGGACGGCGCGGCCCGGCGGGGGGACGCCGCTGCTGAACGGGGCTGGGCCTGGGGCTGCGCGCCA GTCACCACGTTCTGCGCTTTTCCGAGTCGGACATATGAGCAGCGTGGAGCTGGATGATGAACTTTTGGAC CCGGATATGGACCCTCCACATCCCTTCCCCAAGGAGATCCCACACAACGAGAAGCTCCTGTCCCTCAAGT ATGAGAGCTTGGACTATGACAACAGTGAGAACCAGCTGTTCCTGGAGGAGGAGCGGCGGATCAATCACAC GGCCTTCCGGACGGTGGAGATCAAGCGCTGGGTCATCTGCGCCCTCATTGGGATCCTCACGGGCCTCGTG GCCTGCTTCATTGACATCGTGGTGGAAAACCTGGCTGGCCTCAAGTACAGGGTCATCAAGGGCAATATCG ACAAGTTCACAGAGAAGGGCGGACTGTCCTTCTCCCTGTTGCTGTGGGCCACGCTGAACGCCGCCTTCGT GCTCGTGGGCTCTGTGATTGTGGCTTTCATAGAGCCGGTGGCTGCTGGCAGCGGAATCCCCCAGATCAAG TGCTTCCTCAACGGGGTGAAGATCCCCCACGTGGTGCGGCTCAAGACGTTGGTGATCAAAGTGTCCGGTG TGATCCTGTCCGTGGTCGGGGGCCTGGCCGTGGGAAAGGAAGGGCCGATGATCCACTCAGGTTCAGTGAT TGCCGCCGGGATCTCTCAGGGAAGGTCAACGTCACTGAAACGAGATTTCAAGATCTTCGAGTACTTCCGC AGAGACACAGAGAAGCGGGACTTCGTCTCCGCAGGGGCTGCGGCCGGAGTGTCAGCGGCGTTTGGAGCCC CCGTGGGTGGGGTCCTGTTCAGCTTGGAGGAGGGTGCGTCCTTCTGGAACCAGTTCCTGACCTGGAGGAT CTTCTTTGCTTCCATGATCTCCACGTTCACCCTGAATTTTGTTCTGAGCATTTACCACGGGAACATGTGG GACCTGTCCAGCCCAGGCCTCATCAACTTCGGAAGGTTTGACTCGGAGAAAATGGCCTACACGATCCACG AGATCCCGGTCTTCATCGCCATGGGCGTGGTGGGCGGTGTGCTTGGAGCAGTGTTCAATGCCTTGAACTA CTGGCTGACCATGTTTCGAATCAGGTACATCCACCGGCCCTGCCTGCAGGTGATTGAGGCCGTGCTGGTG GCCGCCGTCACGGCCACAGTTGCCTTCGTGCTGATCTACTCGTCGCGGGATTGCCAGCCCCTGCAGGGGG GCTCCATGTCCTACCCGCTGCAGCTCTTTTGTGCAGATGGCGAGTACAACTCCATGGCTGCGGCCTTCTT CAACACCCCGGAGAAGAGCGTGGTGAGCCTCTTCCACGACCCGCCAGGCTCCTACAACCCCCTGACCCTC GGCCTGTTCACGCTGGTCTACTTCTTCCTGGCCTGCTGGACCTACGGGCTCACGGTGTCTGCCGGGGTCT TCATCCCGTCCCTGCTCATCGGGGCTGCCTGGGGCCGGCTCTTTGGGATCTCCCTGTCCTACCTCACGGG GGCGGCGATCTGGGCGGACCCCGGCAAATACGCCCTGATGGGAGCTGCTGCCCAGCTGGGCGGGATTGTG CGGATGACACTGAGCCTGACCGTCATCATGATGGAGGCCACCAGCAACGTGACCTACGGCTTCCCCATCA TGCTGGTGCTCATGACCGCCAAGATCGTGGGCGACGTCTTCATTGAGGGCCTGTACGACATGCACATTCA GCTGCAGAGTGTGCCCTTCCTGCACTGGGAGGCCCCGGTCACCTCACACTCACTCACTGCCAGGGAGGTG ATGAGCACACCAGTGACCTGCCTGAGGCGGCGTGAGAAGGTCGGCGTCATTGTGGACGTGCTGAGCGACA CGGCGTCCAATCACAACGGCTTCCCCGTGGTGGAGCATGCCGATGACACCCAGCCTGCCCGGCTCCAGGG CCTGATCCTGCGCTCCCAGCTCATCGTTCTCCTAAAGCACAAGGTGTTTGTGGAGCGGTCCAACCTGGGC CTGGTACAGCGGCGCCTGAGGCTGAAGGACTTCCGAGACGCCTACCCGCGCTTCCCACCCATCCAGTCCA TCCACGTGTCCCAGGACGAGCGGGAGTGCACCATGGACCTCTCCGAGTTCATGAACCCCTCCCCCTACAC GGTGCCCCAGGAGGCGTCGCTCCCACGGGTGTTCAAGCTGTTCCGGGCCCTGGGCCTGCGGCACCTGGTG GTGGTGGACAACCGCAATCAGGTTGTCGGGTTGGTGACCAGGAAGGACCTCGCCAGGTACCGCCTGGGAA AGAGAGGCTTGGAGGAGCTCTCGCTGGCCCAGACG ACGCGTACGCGGCCGCTCGAGCAGAAACTCATCTCAGAAGAGGATCTGGCAGCAAATGATATCCTGGATT ACAAGGATGACGACGATAAGGTTTAA >RC203450 protein sequence
Red=Cloning site Green=Tags(s) MANVSKKVSWSGRDRDDEEAAPLLRRTARPGGGTPLLNGAGPGAARQSPRSALFRVGHMSSVELDDELLD PDMDPPHPFPKEIPHNEKLLSLKYESLDYDNSENQLFLEEERRINHTAFRTVEIKRWVICALIGILTGLV ACFIDIVVENLAGLKYRVIKGNIDKFTEKGGLSFSLLLWATLNAAFVLVGSVIVAFIEPVAAGSGIPQIK CFLNGVKIPHVVRLKTLVIKVSGVILSVVGGLAVGKEGPMIHSGSVIAAGISQGRSTSLKRDFKIFEYFR RDTEKRDFVSAGAAAGVSAAFGAPVGGVLFSLEEGASFWNQFLTWRIFFASMISTFTLNFVLSIYHGNMW DLSSPGLINFGRFDSEKMAYTIHEIPVFIAMGVVGGVLGAVFNALNYWLTMFRIRYIHRPCLQVIEAVLV AAVTATVAFVLIYSSRDCQPLQGGSMSYPLQLFCADGEYNSMAAAFFNTPEKSVVSLFHDPPGSYNPLTL GLFTLVYFFLACWTYGLTVSAGVFIPSLLIGAAWGRLFGISLSYLTGAAIWADPGKYALMGAAAQLGGIV RMTLSLTVIMMEATSNVTYGFPIMLVLMTAKIVGDVFIEGLYDMHIQLQSVPFLHWEAPVTSHSLTAREV MSTPVTCLRRREKVGVIVDVLSDTASNHNGFPVVEHADDTQPARLQGLILRSQLIVLLKHKVFVERSNLG LVQRRLRLKDFRDAYPRFPPIQSIHVSQDERECTMDLSEFMNPSPYTVPQEASLPRVFKLFRALGLRHLV VVDNRNQVVGLVTRKDLARYRLGKRGLEELSLAQT TRTRPLEQKLISEEDLAANDILDYKDDDDKV |
Chromatograms |
CHROMATOGRAMS
Sequencher program is needed, download here. |
Restriction Sites | SgfI-MluI Cloning Scheme for this gene Plasmid Map |
ACCN | NM_001287 |
ORF Size | 2415 bp |
OTI Disclaimer | Due to the inherent nature of this plasmid, standard methods to replicate additional amounts of DNA in E. coli are highly likely to result in mutations and/or rearrangements. Therefore, OriGene does not guarantee the capability to replicate this plasmid DNA. Additional amounts of DNA can be purchased from OriGene with batch-specific, full-sequence verification at a reduced cost. Please contact our customer care team at custsupport@origene.com or by calling 301.340.3188 option 3 for pricing and delivery. The molecular sequence of this clone aligns with the gene accession number as a point of reference only. However, individual transcript sequences of the same gene can differ through naturally occurring variations (e.g. polymorphisms), each with its own valid existence. This clone is substantially in agreement with the reference, but a complete review of all prevailing variants is recommended prior to use. More info |
OTI Annotation | This clone was engineered to express the complete ORF with an expression tag. Expression varies depending on the nature of the gene. |
Product Components | The ORF clone is ion-exchange column purified and shipped in a 2D barcoded Matrix tube containing 10ug of transfection-ready, dried plasmid DNA (reconstitute with 100 ul of water). |
Reconstitution | 1. Centrifuge at 5,000xg for 5min. 2. Carefully open the tube and add 100ul of sterile water to dissolve the DNA. 3. Close the tube and incubate for 10 minutes at room temperature. 4. Briefly vortex the tube and then do a quick spin (less than 5000xg) to concentrate the liquid at the bottom. 5. Store the suspended plasmid at -20°C. The DNA is stable for at least one year from date of shipping when stored at -20°C. |
Reference Data | |
RefSeq | NM_001287.6 |
RefSeq Size | 4236 bp |
RefSeq ORF | 2418 bp |
Locus ID | 1186 |
UniProt ID | P51798 |
Domains | CBS, voltage_CLC |
Protein Families | Druggable Genome, Ion Channels: Other, Transmembrane |
MW | 88.7 kDa |
Gene Summary | The product of this gene belongs to the CLC chloride channel family of proteins. Chloride channels play important roles in the plasma membrane and in intracellular organelles. This gene encodes chloride channel 7. Defects in this gene are the cause of osteopetrosis autosomal recessive type 4 (OPTB4), also called infantile malignant osteopetrosis type 2 as well as the cause of autosomal dominant osteopetrosis type 2 (OPTA2), also called autosomal dominant Albers-Schonberg disease or marble disease autosoml dominant. Osteopetrosis is a rare genetic disease characterized by abnormally dense bone, due to defective resorption of immature bone. OPTA2 is the most common form of osteopetrosis, occurring in adolescence or adulthood. [provided by RefSeq, Jul 2008] |
Citations (2)
The use of this cDNA Clones has been cited in the following citations: |
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Lysosomal Storage and Albinism Due to Effects of a De Novo CLCN7 Variant on Lysosomal Acidification
,Nicoli, E;Weston, M;Hackbarth, M;Becerril, A;Larson, A;Zein, W;Baker, P;Burke, J;Dorward, H;Davids, M;Huang, Y;Adams, D;Zerfas, P;Chen, D;Markello, T;Toro, C;Wood, T;Elliott, G;Vu, M;Zheng, W;Garrett, L;Tifft, C;Gahl, W;Day-Salvatore, D;Mindell, J;Malicdan, M;Acosta, M;Adams, D;Agrawal, P;Alejandro, M;Allard, P;Alvey, J;Andrews, A;Ashley, E;Azamian, M;Bacino, C;Bademci, G;Baker, E;Balasubramanyam, A;Baldridge, D;Bale, J;Barbouth, D;Batzli, G;Bayrak-Toydemir, P;Beggs, A;Bejerano, G;Bellen, H;Bernstein, J;Berry, G;Bican, A;Bick, D;Birch, C;Bivona, S;Bohnsack, J;Bonnenmann, C;Bonner, D;Boone, B;Bostwick, B;Botto, L;Briere, L;Brokamp, E;Brown, D;Brush, M;Burke, E;Burrage, L;Butte, M;Carey, J;Carrasquillo, O;Chang, T;Chao, H;Clark, G;Coakley, T;Cobban, L;Cogan, J;Cole, F;Colley, H;Cooper, C;Cope, H;Craigen, W;D'Souza, P;Dasari, S;Davids, M;Dayal, J;Dell'Angelica, E;Dhar, S;Dorrani, N;Dorset, D;Douine, E;Draper, D;Duncan, L;Eckstein, D;Emrick, L;Eng, C;Esteves, C;Estwick, T;Fernandez, L;Ferreira, C;Fieg, E;Fisher, P;Fogel, B;Forghani, I;Fresard, L;Gahl, W;Godfrey, R;Goldman, A;Goldstein, D;Gourdine, J;Grajewski, A;Groden, C;Gropman, A;Haendel, M;Hamid, R;Hanchard, N;Hayes, N;High, F;Holm, I;Hom, J;Huang, A;Huang, Y;Isasi, R;Jamal, F;Jiang, Y;Johnston, J;Jones, A;Karaviti, L;Kelley, E;Kiley, D;Koeller, D;Kohane, I;Kohler, J;Krakow, D;Krasnewich, D;Korrick, S;Koziura, M;Krier, J;Kyle, J;Lalani, S;Lam, B;Lanpher, B;Lanza, I;Lau, C;Lazar, J;LeBlanc, K;Lee, B;Lee, H;Levitt, R;Levy, S;Lewis, R;Lincoln, S;Liu, P;Liu, X;Longo, N;Loo, S;Loscalzo, J;Maas, R;Macnamara, E;MacRae, C;Maduro, V;Majcherska, M;Malicdan, M;Mamounas, L;Manolio, T;Mao, R;Markello, T;Marom, R;Marth, G;Martin, B;Martin, M;Martínez-Agosto, J;Marwaha, S;May, T;McCauley, J;McConkie-Rosell, A;McCormack, C;McCray, A;Metz, T;Might, M;Morava-Kozicz, E;Moretti, P;Morimoto, M;Mulvihill, J;Murdock, D;Nath, A;Nelson, S;Newberry, J;Newman, J;Nicholas, S;Novacic, D;Oglesbee, D;Orengo, J;Pace, L;Pak, S;Pallais, J;Palmer, C;Papp, J;Parker, N;Phillips, J;Posey, J;Postlethwait, J;Potocki, L;Pusey, B;Quinlan, A;Raja, A;Renteria, G;Reuter, C;Rives, L;Robertson, A;Rodan, L;Rosenfeld, J;Rowley, R;Ruzhnikov, M;Sacco, R;Sampson, J;Samson, S;Saporta, M;Schaechter, J;Schedl, T;Schoch, K;Scott, D;Shakachite, L;Sharma, P;Shashi, V;Shields, K;Shin, J;Signer, R;Sillari, C;Silverman, E;Sinsheimer, J;Sisco, K;Smith, K;Solnica-Krezel, L;Spillmann, R;Stoler, J;Stong, N;Sullivan, J;Sutton, S;Sweetser, D;Tabor, H;Tamburro, C;Tan, Q;Tekin, M;Telischi, F;Thorson, W;Tifft, C;Toro, C;Tran, A;Urv, T;Velinder, M;Viskochil, D;Vogel, T;Wahl, C;Walley, N;Walsh, C;Walker, M;Wambach, J;Wan, J;Wang, L;Wangler, M;Ward, P;Waters, K;Webb-Robertson, B;Wegner, D;Westerfield, M;Wheeler, M;Wise, A;Wolfe, L;Woods, J;Worthey, E;Yamamoto, S;Yang, J;Yoon, A;Yu, G;Zastrow, D;Zhao, C;Zuchner, S;,
The American Journal of Human Genetics
,PubMed ID 31155284
[CLC7]
|
A model of lysosomal pH regulation
,Yoichi Ishida, Smita Nayak, Joseph A. Mindell, and Michael Grabe,
J. Gen. Physiol., May 2013; 141: 705 - 720.
,PubMed ID 23712550
[CLC7]
|
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Other Versions
SKU | Description | Size | Price |
---|---|---|---|
RC203450L1 | Lenti ORF clone of Human chloride channel 7 (CLCN7), transcript variant 1, Myc-DDK-tagged |
CNY 11,240.00 |
|
RC203450L2 | Lenti ORF clone of Human chloride channel 7 (CLCN7), transcript variant 1, mGFP tagged |
CNY 7,700.00 |
|
RC203450L3 | Lenti ORF clone of Human chloride channel 7 (CLCN7), transcript variant 1, Myc-DDK-tagged |
CNY 7,700.00 |
|
RC203450L4 | Lenti ORF clone of Human chloride channel 7 (CLCN7), transcript variant 1, mGFP tagged |
CNY 7,700.00 |
|
RG203450 | CLCN7 (tGFP-tagged) - Human chloride channel 7 (CLCN7), transcript variant 1 |
CNY 10,440.00 |
|
SC108053 | CLCN7 (untagged)-Human chloride channel 7 (CLCN7), transcript variant 1 |
CNY 5,904.00 |
|
SC320367 | CLCN7 (untagged)-Human chloride channel 7 (CLCN7), transcript variant 1 |
CNY 5,904.00 |