Tpr (NM_133780) Mouse Tagged ORF Clone

Specifications

Product Data
Type	Mouse Tagged ORF Clone
Tag	Myc-DDK
Synonyms	2610029M07Rik; C77892
Vector	pCMV6-Entry
E. coli Selection	Kanamycin (25 ug/mL)
Mammalian Cell Selection	Neomycin
Sequence Data	ORF Nucleotide Sequence (showhide) >MR215011 representing NM_133780 Red=Cloning site Blue=ORF Green=Tags(s) TTTTGTAATACGACTCACTATAGGGCGGCCGGGAATTCGTCGACTGGATCCGGTACCGAGGAGATCTGCC GCCGCGATCGCC ATGACCTCTGGTGGCTCGGCTTCTAGAAGTGGCCACAGAGGAGTACCCATGACATCCCGGGGTTTTGACG GGTCCCGCCGCGGGAGTCTCAGGCGGGCAGGCGCGCGAGAGACCGCGAGCGAGGCGGCGGACGGGGCGGC TCCGGCGGCTGGGCTCCGCGCTTCTCCTTGCTCCTTGGCTTCTCCTTCAGCCGCTGCGGCTGTTGCCGCG ATCCCGGCCGACATGGCGGCGGTGTTGCAGCAAGTGCTGGAGCGCCCGGAACTGAACAAACTGCCGAAGT CGACGCAGAACAAACTTGAGAAGTTCCTGGCCGAGCAGCAGTCCGAGATCGACTGCCTGAAGGGGCGGCA CGAGAAATTTAAGGTGGAGAGTGAACAACAATACTTTGAGATAGAGAAGAGGCTCTCACAGAGTCAGGAG AGGCTTGTCACTGAAACCCGGGAGTGTCAGAACTTGAGGCTGGAGCTTGAGAAGCTAAATAACCAAGTAA AAGTGTTAACTGAAAAAACCAAAGAACTGGAAACTGCTCAAGACCGTAATCTGGGCATTCAGAGCCAGTT TACAAGAGCAAAGGAAGAGTTAGAAGCTGAAAAAAGAGATTTAATCAGAACCAATGAGAGGTTATCTCAG GAAGTTGAATATTTAACAGAGGATGTTAAACGTCTAAATGAAAAACTTAAAGAAAGCAATACGACGAAGG GTGAACTTCAGTTAAAGCTGGATGAACTTCAAGCTTCTGATGTTGCTGTGAAGTATCGAGAAAAACGCTT AGAACAAGAAAAGGAATTGCTACACAATCAAAATTCATGGCTGAACACAGAGTTGAAAACCAAAACTGAT GAGCTGTTGGCTCTAGGAAGAGAAAAAGGAAATGAAATTCTGGAACTTAAGTGTAATCTTGAAAACAAAA AAGAAGAGGTTCTGAGACTGGAAGAACAGATGAATGGCTTGAAAACATCAAATGAACATCTTCAGAAACA TGTAGAGGATTTGTTGACAAAATTAAAAGAGGCCAAAGAACAGCAGGCCAGTATGGAAGAGAAATTCCAC AATGAGTTAAATGCTCACATAAAGCTCTCTAATCTCTACAAGAGCGCTGCTGATGACTCAGAGGCAAAGA GTAATGAGCTAACCCGGGCAGTGGACGAGCTGCACAAACTGCTCAAAGAAGCAGGAGAAGCCAACAAAAC AATACAAGATCATCTTCTACAAGTGGAAGAATCTAAAGATCAGATGGAAAAAGAAATGCTTGAGAAAATA GGAAAATTGGAGAAGGAATTAGAGAATGCAAATGACCTGCTTTCTGCTACAAAACGTAAAGGAGCTATAT TGTCTGAAGAAGAGCTTGCAGCCATGTCTCCCACCGCAGCAGCTGTAGCTAAAATTGTAAAGCCTGGCAT GAAATTAACTGAGCTATATAATGCTTATGTGGAAACTCAGGATCAGTTGCTTTTGGAAAAACAAGAAAAT AAAAGGATTAATAAGTATCTGGATGAGATAGTAAAAGAAGTGGAAGCCAAAGCACCGATTTTGAAACGCC AGCGCGAAGAGTATGAGCGTGCACAGAAAGCTGTGGCCAGTCTTTCTGCAAAGCTTGAGCAAGCTATGAA GGAGATTCAGCGATTGCAGGAGGACACTGATAAAGCCAACAAACATTCATCGGTACTTGAAAGGGACAAT CAGAGAATGGAAATACAAATAAAAGACCTTTCGCAACAGATAAGAGTGCTCTTGATGGAACTTGAAGAAG CCAGGGGTAACCATGTAATTCGGGATGAGGAGGTCAGCTCTGCTGACATCAGTAGTTCGTCTGAAGTGAT TTCGCAGCACCTAGTATCTTACAGGAACATCGAAGAGCTTCAGCAGCAGAATCAGCGTCTGCTATTCGCT CTTCGAGAACTTGGGGAAACCAGGGAACGAGAAGAGCAAGAGACAACTTCCTCTAAGATTGCTGAACTTC AGCATAAACTTGAGAACTCTCTCGCTGAACTGGAACAGCTCCGTGAGTCACGACAACATCAGATGCAGCT TGTTGATTCCATAGTGCGTCAGCGTGACATGTACCGAATTTTATTGTCACAAACAACAGGAATGGCCATT CCCTTACAAGCTTCAAGTTTAGATGATATTTCTCTTCTCTCAACTCCAAAACGTTCAAGTACATCACAGA CTGTTTCCACTCCTGCTCCGGAACCCGTCATTGACTCCACAGAGGCTATAGAAGCAAAGGCTGCCCTTAA ACAGTTGCAGGAAATCTTTGAGAACTATAAAAAAGAAAAAATAGACAGTGAGAAACTTCAAAATGAGCAG CTAGAGAAACTTCAAGAGCAAGTCACAGACCTGCGCTCACAAAACACCAAAATTTCTACTCAGCTAGATT TTGCTTCTAAACGTTATGAAATGCTGCAAGATAATGTAGAAGGATATCGTCGAGAAATAACATCTCTACA AGAGAGAAATCAGAAACTCACTGCAACTACTCAGAAGCAGGAACAGATCATCAACACAATGACGCAAGAC TTGAGAGGAGCCAATGAAAAGCTAGCAGTTGCAGAAGTAAGAGCAGAAAATTTAAAGAAGGAAAAAGAAA TGCTTAAATTGTCTGAAGTCCGTCTTTCTCAGCAAAGAGAGTCTTTGTTAGCTGAACAGAGGGGGCAGAA CTTGTTGCTGACTAATCTACAGACAATCCAGGGCATACTAGAGCGATCTGAGACTGAAACCAAACAAAGG CTGAATAGCCAGATAGAAAAACTGGAGCATGAGATCTCTCACTTGAAGAAGAAATTGGAAAACGAGGTGG AACAAAGACATACGCTTACGAGGAATCTAGACGTTCAACTATTAGATACCAAGAGACAGCTAGATACAGA AATAAATCTCCATCTTAACACAAAAGAACTGTTAAAAAATGCTCAGAAGGACATTGCTACACTGAAACAG CACCTTAATAATATGGAAGCCCAGCTCGCTTCACAGTCCACACAGAGAACCGGTAAAGGTCAGCCTGGTG ACAGAGATGACGTTGATGATCTTAAAAGTCAGCTAAGGCAGGCTGAAGAACAGGTCAATGACTTGAAGGA GAGACTCAAGACAAGTACCAGTAATGTGGAGCAGTATCGAGCCATGGTGACCAGCTTAGAAGATTCCCTG AACAAGGAGAAACAGGTGACTGAGGAGGTTCATAAGAACATTGAAGTTCGCTTGAAAGAATCAGCAGAGT TTCAGACACAGTTGGAGAAGAAATTGATGGAAGTAGAGAAGGAAAAGCAAGAACTTCAGGATGATAAGAG GAAAGCCATCGAGAGCATGGAACAGCAATTAAGTGAATTGAAGAAAACACTGTCTACTGTTCAGAATGAA GTACAAGAAGCTCTTCAGAGAGCAAGCACAGCTTTAAGTAATGAACAGCAAGCCAGGCGTGACTGTCAGG AACAAGCTAAAATCGCTGTGGAAGCCCAGAATAAGTATGAGAGAGAATTGATGCTACATGCTGCTGATGT CGAAGCTCTGCAAGCTGCCAAGGAACAGGTTTCAAAAATGACATCAATCCGTCAGCATTTGGAAGAAACA ACTCAGAAAGCAGAATCCCAGTTGTTGGAATGTAAAGCATCTTGGGAAGAGAGAGAGAGAGTGTTGAAGG ATGAAGTTTCCAAAAGTGTGTCTCGCTGTGAAGATCTAGAGAAACAAAACCGACTACTTCATGATCAAAT CGAAAAATTAAGTGACAAGGTGGTCACCTCTATGAAGGATGCTGTGCAAGCGCCATTAAATGTATCTCTC AATGAAGAAGGGAAATCTCAAGAACAAATTCTAGAAATTCTTAGATTTATTCGACGAGAAAAAGAAATTG CTGAAACTAGGTTTGAGGTGGCTCAGGTTGAGAGTTTGCGGTATCGACAAAGAGTTGAACTTCTAGAACG GGAGTTGCAAGAACTGCAGGATAGCCTGAATGTGGAAAGGGAAAAGGTGCAGGTAACTGCAAAAACAATG GCGCAACATGAAGAGCTGATGAAGAAAACTGAAACAATGAACGTTGTTATGGAGACCAACAAGATGCTAC GGGAGGAAAAGGAAAGGCTCGAACAGAACCTACAACAAATGCAAGCCAAGGTGAGGAAACTGGAGTTAGA CATTTTACCCTTACAAGAAGCCAATGCTGAGCTGAGTGAGAAAAGCGGTATGCTCCAGGCAGAAAAGAAG CTACTGGAAGAGGATGTTAAGCGTTGGAAAGCACGGAACCAGCAACTAATAAATCAACAGAAAGATCCAG ACACAGAAGAATATCGAAAGTTGCTTTCTGAAAAGGAAATTCACACTAAGAGAATCCAACAGCTAAATGA AGAAGTTGGAAGGCTTAAGGCTGAAATTGCAAGATCAAATGCATCCTTGACTAACAACCAGAATTTAATC CAGAGTCTGCGGGAAGACTTAAGTAAAGCACGGACTGAAAAGGAAGGCATTCAGAAAGATTTAGATGCCA AAATAATTGATATACAGGAAAAGGTCAAAACAATCACTCAAGTCAAGAAAATTGGACGCAGGTACAAGAC TCAGTTTGAAGAACTGAAAGCGCAACAAAACAAGGCCATGGAGACTTCCACTCAGTCTTCAGGAGACCAT CAGGAACAGCACATCTCTGTCCAGGAAATGCAGGAGCTCAAAGATACCCTCAGCCAATCCGAAACAAAGA CAAAGTCACTTGAGGGTCAAGTAGAGAATCTGCAGAAGACATTATCTGAAAAAGAGACAGAAGCAAGAAG TCTCCAGGAGCAGACGGTGCAGCTTCAGTCTGAACTGTCACGCCTTCGTCAGGACCTCCAGGATAAAACC ACAGAGGAGCAGCTCCGACAGCAAATGAATGAAAAGACTTGGAAGACACTTGCACTAGCCAAATCAAAAA TTACACATCTATCTGGTGTGAAAGATCAGCTGACTAAAGAAATTGAAGAACTTAAACAAAGGAACGGAGC TCTAGATCAGCAGAAAGATGAGCTTGATGTCCGAATGACTGCTCTTAAGTCCCAGTATGAAGGTCGGATT AGTCGCTTAGAGAGAGAGCTCAGAGAGCATCAAGAGCGACACCTTGAGCAGAGGGATGAGCCTCAAGAAC CCACTAATAAGGCTCCAGAACAGCAAAGACAAATCACACTGAAAACCACTCCAGCTTCTGGTGAAAGAGG AATTGCCAGCACATCAGACCCACCAACAGCCAATATCAAGCCAACTCCTGTTGTTTCTACTCCAAGTAAA GTGACAGCTGCAGCTATGGCTGGGAATAAGTCGACACCCAGGGCAAGTATCCGCCCAATGGTTACACCTG CAACGGTCACAAATCCGACCACTACCCCAACAGCAACCGTAATGCCTACTACACAGGTGGAGTCACAGGA AGCTATGCAGTCAGAAGGGCCTGTGGAACATGTTCCAGTATTTGGAAACGCAAGTGGATCTGTTCGTTCT ACTAGTCCTAATGTTCAGCCCTCCATTTCTCAGCCCATCCTAACTGTACAGCAGCAAACACAAGCTACAG CTTTTGTACAACCCACTCAACAGAGCCACCCGCAGATTGAGCCTACAAATCAAGAATTGTCCCCAAACAT AGTTGAGGTAGTACAAAGTTCCCCAGTGGAGCGTCCATCTACTTCCACAGCAGTATTTGGCACTGTTTCA GCTACCCCAAGTTCCTCCTTGCCAAAGCGCACTCGGGAGGAGGAAGAGGACAGCACCATGGAAGCAGGAG ACCAAGTCTCTGAGGACACAGTGGAAATGCCTCTCCCGAAGAAGCTGAAGATGGTCACACCCGTTGGAAC CGAGGAAGAAGTTATGGCAGAAGAAAGTACTGATGGAGAGGCAGAAACTCAAGCCTATAATCAGGACTCT CAAGATTCCATTGGAGAAGGAGTTACCCAGGGAGATTATACACCAATGGAAGACAGTGAAGAAACATCAC AATCTCTACAAATCGATCTTGGACCACTTCAGTCAGATCAACAGACTACTTCCTCTCAAGATGGTCAAGG CAAAGGAGATGATGTAATTGTAATTGACAGTGATGATGAAGATGATGATGAAGAAAATGATGGCGAACAT GAAGATTATGAAGAAGACGAAGATGATGATGATGATGAAGAAGATGACACGGGGATGGGAGATGAGGGTG AAGATAGTAATGAAGGAACTGGTAGTGCAGATGGTAATGATGGATATGAAGCTGATGATGCTGAGGGTGG TGATGGGACTGATCCAGGTACAGAAACAGAAGAAAGTATGGGTGGAGCTGAAAGTCATCAGAGAGCTGCT GATTCTCAAAACAGTGGTGAAGGAAATACAAGTGCAGCAGAGTCTTCCTTCTCTCAGGAGGTTGCCAGGG AACAGCAGCCCACGTCAGCGTCTGAGAGACAGACTCCGCAAGCACCGCAGTCACCAAGGCGCCCTCCACA TCCTCTCCCCCCACGCCTGACCATTCACGCCCCACCTCAGGAGCTGGGACCACCAGTTCAGAGAATTCAG ATGACCCGGAGGCAGTCTGTAGGGCGTGGTCTTCAGTTGACTCCAGGAATAGGTGGCATGCAACAACACT TTTTTGATGATGAAGACAGAACAGTCCCGAGTACCCCAACTCTTGTGGTGCCACATCGCACTGATGGGTT TGCTGAAGCTATTCATTCCCCACAGGTTGCCGGTGTTCCTAGATTCCGGTTTGGGCCACCTGAAGACATG CCACAGACAAGTTCCAGTCACTCTGATCTTGGCCAACTTGCTTCTCAAGGAGGTTTGGGAATGTATGAAA CACCCCTTTTTCTGGCTCATGAAGAAGAGTCTGGTGGCCGCAGCGTTCCCACTACGCCTCTCCAAGTAGC AGCCCCAGTGACTGTGTTCACTGAGAGTACCACCTCTGATGCTTCAGAACATGCCTCTCAGTCGGTTCCC ATGGTGACAACGTCTACGGGCACTTTATCCACGACAAACGAAACAGCAGCAGGTGACGACGGAGATGAAG TATTTGTAGAGGCGGAGTCTGAAGGTATTAGTTCAGAGGCAGGCCTAGAAATTGATAGCCAGCAGGAAGA GGAGCCTGTCCAAGCATCTGATGAATCAGATCTTCCCTCAACCAGCCAAGATCCCCCTTCGAGCTCCTCC GTAGATACCAGTAGTAGTCAACCGAAGCCTTTCAGACGAGTAAGACTTCAGACAACCTTGAGACAGGGTG TTCGTGGTCGTCAGTTTAACCGACAAAGAGGTATAAGCCATGCAATGGGAGGAAGAGGAGGAATAAATAG AGGGAATATTAAT ACGCGTACGCGGCCGCTCGAGCAGAAACTCATCTCAGAAGAGGATCTGGCAGCAAATGATATCCTGGATT ACAAGGATGACGACGATAAGGTTTAA Protein Sequence (showhide) >MR215011 representing NM_133780 Red=Cloning site Green=Tags(s) MTSGGSASRSGHRGVPMTSRGFDGSRRGSLRRAGARETASEAADGAAPAAGLRASPCSLASPSAAAAVAA IPADMAAVLQQVLERPELNKLPKSTQNKLEKFLAEQQSEIDCLKGRHEKFKVESEQQYFEIEKRLSQSQE RLVTETRECQNLRLELEKLNNQVKVLTEKTKELETAQDRNLGIQSQFTRAKEELEAEKRDLIRTNERLSQ EVEYLTEDVKRLNEKLKESNTTKGELQLKLDELQASDVAVKYREKRLEQEKELLHNQNSWLNTELKTKTD ELLALGREKGNEILELKCNLENKKEEVLRLEEQMNGLKTSNEHLQKHVEDLLTKLKEAKEQQASMEEKFH NELNAHIKLSNLYKSAADDSEAKSNELTRAVDELHKLLKEAGEANKTIQDHLLQVEESKDQMEKEMLEKI GKLEKELENANDLLSATKRKGAILSEEELAAMSPTAAAVAKIVKPGMKLTELYNAYVETQDQLLLEKQEN KRINKYLDEIVKEVEAKAPILKRQREEYERAQKAVASLSAKLEQAMKEIQRLQEDTDKANKHSSVLERDN QRMEIQIKDLSQQIRVLLMELEEARGNHVIRDEEVSSADISSSSEVISQHLVSYRNIEELQQQNQRLLFA LRELGETREREEQETTSSKIAELQHKLENSLAELEQLRESRQHQMQLVDSIVRQRDMYRILLSQTTGMAI PLQASSLDDISLLSTPKRSSTSQTVSTPAPEPVIDSTEAIEAKAALKQLQEIFENYKKEKIDSEKLQNEQ LEKLQEQVTDLRSQNTKISTQLDFASKRYEMLQDNVEGYRREITSLQERNQKLTATTQKQEQIINTMTQD LRGANEKLAVAEVRAENLKKEKEMLKLSEVRLSQQRESLLAEQRGQNLLLTNLQTIQGILERSETETKQR LNSQIEKLEHEISHLKKKLENEVEQRHTLTRNLDVQLLDTKRQLDTEINLHLNTKELLKNAQKDIATLKQ HLNNMEAQLASQSTQRTGKGQPGDRDDVDDLKSQLRQAEEQVNDLKERLKTSTSNVEQYRAMVTSLEDSL NKEKQVTEEVHKNIEVRLKESAEFQTQLEKKLMEVEKEKQELQDDKRKAIESMEQQLSELKKTLSTVQNE VQEALQRASTALSNEQQARRDCQEQAKIAVEAQNKYERELMLHAADVEALQAAKEQVSKMTSIRQHLEET TQKAESQLLECKASWEERERVLKDEVSKSVSRCEDLEKQNRLLHDQIEKLSDKVVTSMKDAVQAPLNVSL NEEGKSQEQILEILRFIRREKEIAETRFEVAQVESLRYRQRVELLERELQELQDSLNVEREKVQVTAKTM AQHEELMKKTETMNVVMETNKMLREEKERLEQNLQQMQAKVRKLELDILPLQEANAELSEKSGMLQAEKK LLEEDVKRWKARNQQLINQQKDPDTEEYRKLLSEKEIHTKRIQQLNEEVGRLKAEIARSNASLTNNQNLI QSLREDLSKARTEKEGIQKDLDAKIIDIQEKVKTITQVKKIGRRYKTQFEELKAQQNKAMETSTQSSGDH QEQHISVQEMQELKDTLSQSETKTKSLEGQVENLQKTLSEKETEARSLQEQTVQLQSELSRLRQDLQDKT TEEQLRQQMNEKTWKTLALAKSKITHLSGVKDQLTKEIEELKQRNGALDQQKDELDVRMTALKSQYEGRI SRLERELREHQERHLEQRDEPQEPTNKAPEQQRQITLKTTPASGERGIASTSDPPTANIKPTPVVSTPSK VTAAAMAGNKSTPRASIRPMVTPATVTNPTTTPTATVMPTTQVESQEAMQSEGPVEHVPVFGNASGSVRS TSPNVQPSISQPILTVQQQTQATAFVQPTQQSHPQIEPTNQELSPNIVEVVQSSPVERPSTSTAVFGTVS ATPSSSLPKRTREEEEDSTMEAGDQVSEDTVEMPLPKKLKMVTPVGTEEEVMAEESTDGEAETQAYNQDS QDSIGEGVTQGDYTPMEDSEETSQSLQIDLGPLQSDQQTTSSQDGQGKGDDVIVIDSDDEDDDEENDGEH EDYEEDEDDDDDEEDDTGMGDEGEDSNEGTGSADGNDGYEADDAEGGDGTDPGTETEESMGGAESHQRAA DSQNSGEGNTSAAESSFSQEVAREQQPTSASERQTPQAPQSPRRPPHPLPPRLTIHAPPQELGPPVQRIQ MTRRQSVGRGLQLTPGIGGMQQHFFDDEDRTVPSTPTLVVPHRTDGFAEAIHSPQVAGVPRFRFGPPEDM PQTSSSHSDLGQLASQGGLGMYETPLFLAHEEESGGRSVPTTPLQVAAPVTVFTESTTSDASEHASQSVP MVTTSTGTLSTTNETAAGDDGDEVFVEAESEGISSEAGLEIDSQQEEEPVQASDESDLPSTSQDPPSSSS VDTSSSQPKPFRRVRLQTTLRQGVRGRQFNRQRGISHAMGGRGGINRGNIN TRTRPLEQKLISEEDLAANDILDYKDDDDKV
Chromatograms	CHROMATOGRAMS Sequencher program is needed, download here.
Restriction Sites	SgfI-MluI      Cloning Scheme for this gene      Plasmid Map
ACCN	NM_133780
ORF Size	7293 bp
OTI Disclaimer	The molecular sequence of this clone aligns with the gene accession number as a point of reference only. However, individual transcript sequences of the same gene can differ through naturally occurring variations (e.g. polymorphisms), each with its own valid existence. This clone is substantially in agreement with the reference, but a complete review of all prevailing variants is recommended prior to use. More info
OTI Annotation	This clone was engineered to express the complete ORF with an expression tag. Expression varies depending on the nature of the gene.
Product Components	The ORF clone is ion-exchange column purified and shipped in a 2D barcoded Matrix tube containing 10ug of transfection-ready, dried plasmid DNA (reconstitute with 100 ul of water).
Reconstitution	1. Centrifuge at 5,000xg for 5min. 2. Carefully open the tube and add 100ul of sterile water to dissolve the DNA. 3. Close the tube and incubate for 10 minutes at room temperature. 4. Briefly vortex the tube and then do a quick spin (less than 5000xg) to concentrate the liquid at the bottom. 5. Store the suspended plasmid at -20°C. The DNA is stable for at least one year from date of shipping when stored at -20°C.
Reference Data
RefSeq	NM_133780.3, NP_598541.3
RefSeq Size	7550 bp
RefSeq ORF	7296 bp
Locus ID	108989
UniProt ID	F6ZDS4
MW	274 kDa
Gene Summary	Component of the nuclear pore complex (NPC), a complex required for the trafficking across the nuclear envelope. Functions as a scaffolding element in the nuclear phase of the NPC essential for normal nucleocytoplasmic transport of proteins and mRNAs, plays a role in the establishment of nuclear-peripheral chromatin compartmentalization in interphase, and in the mitotic spindle checkpoint signaling during mitosis. Involved in the quality control and retention of unspliced mRNAs in the nucleus; in association with NUP153, regulates the nuclear export of unspliced mRNA species bearing constitutive transport element (CTE) in a NXF1- and KHDRBS1-independent manner. Negatively regulates both the association of CTE-containing mRNA with large polyribosomes and translation initiation. Does not play any role in Rev response element (RRE)-mediated export of unspliced mRNAs. Implicated in nuclear export of mRNAs transcribed from heat shock gene promoters; associates both with chromatin in the HSP70 promoter and with mRNAs transcribed from this promoter under stress-induced conditions. Plays a limited role in the regulation of nuclear protein export. Modulates the nucleocytoplasmic transport of activated MAPK1/ERK2 and huntingtin/HTT and may serve as a docking site for the XPO1/CRM1-mediated nuclear export complex. Plays also a role as a structural and functional element of the perinuclear chromatin distribution; involved in the formation and/or maintenance of NPC-associated perinuclear heterochromatin exclusion zones (HEZs). Finally, acts as a spatial regulator of the spindle-assembly checkpoint (SAC) response ensuring a timely and effective recruitment of spindle checkpoint proteins like MAD1L1 and MAD2L1 to unattached kinetochore during the metaphase-anaphase transition before chromosome congression. Its N-terminus is involved in activation of oncogenic kinases (By similarity).[UniProtKB/Swiss-Prot Function]

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