Senp6 (NM_146003) Mouse Tagged Lenti ORF Clone
CAT#: MR210918L3
- LentiORF®
Lenti ORF clone of Senp6 (Myc-DDK-tagged) - Mouse SUMO/sentrin specific peptidase 6 (Senp6)
"NM_146003" in other vectors (3)
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CNY 11,780.00
CNY 600.00
Specifications
Product Data | |
Type | Mouse Tagged ORF Clone |
Tag | Myc-DDK |
Synonyms | 2810017C20Rik; E130319N12Rik; mKIAA0797; Susp1 |
Vector | pLenti-C-Myc-DDK-P2A-Puro |
E. coli Selection | Chloramphenicol (34 ug/mL) |
Mammalian Cell Selection | Puromycin |
Sequence Data |
The ORF insert of this clone is exactly the same as(MR210918).
|
Restriction Sites |
SgfI-MluI
Cloning Scheme for this gene
Plasmid Map
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ACCN | NM_146003 |
ORF Size | 3396 bp |
OTI Disclaimer | The molecular sequence of this clone aligns with the gene accession number as a point of reference only. However, individual transcript sequences of the same gene can differ through naturally occurring variations (e.g. polymorphisms), each with its own valid existence. This clone is substantially in agreement with the reference, but a complete review of all prevailing variants is recommended prior to use. More info |
OTI Annotation | This clone was engineered to express the complete ORF with an expression tag. Expression varies depending on the nature of the gene. |
Product Components | The ORF clone is ion-exchange column purified and shipped in a 2D barcoded Matrix tube containing 10ug of transfection-ready, dried plasmid DNA (reconstitute with 100 ul of water). |
Reconstitution | 1. Centrifuge at 5,000xg for 5min. 2. Carefully open the tube and add 100ul of sterile water to dissolve the DNA. 3. Close the tube and incubate for 10 minutes at room temperature. 4. Briefly vortex the tube and then do a quick spin (less than 5000xg) to concentrate the liquid at the bottom. 5. Store the suspended plasmid at -20°C. The DNA is stable for at least one year from date of shipping when stored at -20°C. |
Reference Data | |
RefSeq | NM_146003.2, NP_666115.2 |
RefSeq Size | 4938 bp |
RefSeq ORF | 3399 bp |
Locus ID | 215351 |
UniProt ID | Q6P7W0 |
Gene Summary | Protease that deconjugates SUMO1, SUMO2 and SUMO3 from targeted proteins. Processes preferentially poly-SUMO2 and poly-SUMO3 chains, but does not efficiently process SUMO1, SUMO2 and SUMO3 precursors. Deconjugates SUMO1 from RXRA, leading to transcriptional activation. Involved in chromosome alignment and spindle assembly, by regulating the kinetochore CENPH-CENPI-CENPK complex. Desumoylates PML and CENPI, protecting them from degradation by the ubiquitin ligase RNF4, which targets polysumoylated proteins for proteasomal degradation. Desumoylates also RPA1, thus preventing recruitment of RAD51 to the DNA damage foci to initiate DNA repair through homologous recombination.[UniProtKB/Swiss-Prot Function] |
Documents
Product Manuals |
FAQs |
SDS |
Resources
Other Versions
SKU | Description | Size | Price |
---|---|---|---|
MC223670 | Senp6 (untagged) - Mouse SUMO/sentrin specific peptidase 6 (Senp6), (10ug) |
CNY 14,540.00 |
|
MR210918 | Senp6 (Myc-DDK-tagged) - Mouse SUMO/sentrin specific peptidase 6 (Senp6) |
CNY 7,880.00 |
|
MR210918L4 | Lenti ORF clone of Senp6 (mGFP-tagged) - Mouse SUMO/sentrin specific peptidase 6 (Senp6) |
CNY 11,780.00 |