Mapk8ip3 (BC060603) Mouse Tagged ORF Clone
CAT#: MG211916
- TrueORF®
Mapk8ip3 (tGFP-tagged) - Mouse mitogen-activated protein kinase 8 interacting protein 3 (cDNA clone MGC:79152 IMAGE:5706805)
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CNY 9,600.00
货期*
7周
规格
经常一起买 (5)
Specifications
Product Data | |
Type | Mouse Tagged ORF Clone |
Tag | TurboGFP |
Synonyms | Jip3, JSAP1, JSAP1a, JSAP1b, JSAP1c, JSAP1d, Syd2, mKIAA1066 |
Vector | pCMV6-AC-GFP |
E. coli Selection | Ampicillin (100 ug/mL) |
Mammalian Cell Selection | Neomycin |
Sequence Data |
>MG211916 representing BC060603
Red=Cloning site Blue=ORF Green=Tags(s) TTTTGTAATACGACTCACTATAGGGCGGCCGGGAATTCGTCGACTGGATCCGGTACCGAGGAGATCTGCC GCCGCGATCGCC ATGATGGAGATCCAGATGGACGAGGGAGGAGGAGTGGTGGTGTACCAAGACGACTACTGCTCGGGCTCGG TCATGTCGGAGCGTGTGTCGGGCCTGGCGGGCTCCATCTACCGCGAGTTCGAGCGCCTCATTCACTGCTA TGACGAGGAGGTGGTCAAGGAGCTCATGCCGCTGGTGGTGAACGTGCTGGAGAACCTTGACTCGGTGCTG AGCGAGAACCAGGAGCACGAGGTGGAGCTGGAGCTCCTACGCGAGGACAACGAGCAGCTGCTCACGCAAT ACGAGCGCGAGAAGGCGCTGCGCAAACAGGCCGAGGAGAAATTCATCGAATTTGAAGATGCCTTGGAACA AGAGAAGAAAGAACTCCAGATCCAGGTAGAACATTATGAGTTTCAGACACGCCAGCTGGAGCTAAAGGCC AAAAACTATGCAGATCAGATTTCCCGACTGGAGGAACGAGAATCGGAGATGAAGAAGGAATACAATGCCC TGCACCAGCGGCACACAGAGATGATCCAGACCTATGTGGAACACATTGAAAGATCCAAGATGCAGCAAGT TGGGGGTAGCGGCCAAACAGAAAGCAGCCTGCCCGGGCGGAGTCCTCGCCAGTCGTGGAGGAAAAGCAGG AAGGAGCGTCCCACCTCTCTGAATGTCTTCCCCCTGGCTGATGGCATGTGTCCAAATGATGAGATGTCTG AGTCAGGCCAGTCCTCAGCAGCTGCAACACCCAGTACCACAGGTACCAAGTCCAACACACCCACGTCCTC CGTGCCCTCAGCAGCAGTCACGCCACTCAACGAGAGCCTACAGCCCCTGGGGGACTATGTCAGTGTCACA AAGAACAACAAGCAGGCCCGAGAGAAGCGCAATAGCCGTAACATGGAGGTCCAGGTCACCCAAGAGATGC GGAACGTCAGTATCGGCATGGGCAGCAGTGACGAGTGGTCCGATGTTCAGGACATTATCGACTCCACCCC AGAGCTGGATGTGTGTCCTGAAACCCGTCTGGAGCGCACAGGAAGCAGCCCAACCCAGGGAATTGTAAAC AAAGCTTTTGGAATCAACACTGACTCCTTGTATCACGAACTCTCCACGGCGGGATCTGAGGTCATCGGGG ATGTGGACGAGGGAGCTGATCTCCTAGGGGAGTTTTCAGTGCGCGATGATTTTTTTGGAATGGGCAAAGA AGTGGGGAACCTGCTGCTGGAGAACTCACAGCTTCTAGAGACAAAAAATGCTTTAAATGTAGTGAAGAAT GACCTCATTGCTAAGGTTGACCAACTGTCAGGAGAACAGGAGGTCCTGAAGGGTGAGCTGGAAGCAGCCA AGCAAGCCAAAGTCAAGCTGGAGAACCGAATCAAAGAGCTTGAAGAAGAACTGAAGAGAGTCAAGTCAGA GGCAGTAACTGCCCGCCGTGAGCCCAGAGAAGAGGTGGAGGATGTAAGCAGCTATCTCTGTACAGAATTG GACAAAATCCCCATGGCCCAGCGCCGACGCTTCACACGGGTGGAGATGGCCCGAGTGCTCATGGAACGCA ACCAGTACAAGGAACGCCTCATGGAGCTGCAGGAGGCTGTGAGGTGGACTGAAATGATCAGAGCATCAAG GGAACACCCATCTGTCCAGGAGAAGAAGAAGTCCACCATCTGGCAGTTCTTTAGTCGCCTCTTCAGCTCC TCATCTAGCCCCCCTCCGGCCAAACGATCCTACCCATCTGTGAACATTCACTACAAGTCACCCACTGCAG CTGGCTTTAGCCAGCGTCGCAGCCATGCTTTGTGCCAGATCTCAGCCGGCAGCAGGCCCCTGGAGTTCTT CCCTGATGATGACTGCACCTCTTCTGCCCGGCGGGAGCAGAAGCGGGAGCAGTACCGCCAGGTTCGTGAA CACGTGCGCAATGATGACGGGAGGCTGCAGGCCTGTGGGTGGAGCCTGCCTGCCAAGTACAAGCAGCTGA GCCCCAATGGAGGCCAGGAAGACACCCGGATGAAAAATGTGCCTGTCCCTGTGTACTGCCGCCCTCTGGT GGAGAAGGACCCTTCGACAAAGCTGTGGTGTGCTGCTGGTGTCAACCTGAGTGGGTGGAAGCCACATGAA GAGGACTCTAGCAATGGACCCAAGCCTGTACCAGGTCGAGACCCTCTGACCTGTGACCGGGAAGGAGAAG GCGAACCCAAGAGCACACACCCATCACCTGAGAAGAAGAAGGCAAAGGAAACCCCTGAGGCAGATGCTAC CTCCAGTCGGGTATGGATCCTCACCAGCACCCTGACAACCAGCAAGGTGGTGATCATTGATGCCAACCAG CCAGGCACAATTGTGGATCAGTTCACAGTCTGCAATGCCCACGTCCTGTGTATCTCCAGCATTCCTGCGG CCAGTGACAGTGACTATCCCCCTGGGGAGATGTTCCTAGACAGTGATGTGAACCCTGAAGATTCAGGTGC TGATGGTGTGCTGGCTGGCATCACCCTGGTGGGGTGTGCTACCCGCTGCAATGTTCCACGTAGCAACTGT TCCTCACGAGGAGACACCCCAGTACTGGACAAGGGGCAGGGGGATGTGGCGACCACTGCCAATGGGAAGG TCAACCCGTCCCAATCCACAGAAGAAGCCACAGAAGCCACGGAGGTGCCAGACCCTGGTCCCAGCGAGTC AGAAGCAACGACAGTCCGGCCCGGGCCTCTCACAGAGCATGTCTTTACTGACCCAGCACCCACCCCATCC TCCAGCACCCAGCCTGCCAGTGAGAATGGGTCAGAGTCCAATGGCACCATTGTACAGCCTCAGGTGGAGC CCAGTGGGGAACTCTCAACAACAACCAGTAGCGCTGCACCCACTATGTGGCTAGGAGCCCAGAATGGCTG GCTCTATGTGCATTCAGCGGTAGCCAACTGGAAGAAGTGTCTGCACTCCATCAAGCTAAAAGACTCTGTG CTGAGCCTGGTGCATGTCAAAGGCCGAGTGCTGGTAGCTCTTGCAGATGGGACCCTGGCTATCTTCCATC GTGGAGAGGATGGCCAGTGGGACCTGAGCAACTACCACCTAATGGACCTGGGCCACCCACACCACTCCAT CCGCTGCATGGCTGTTGTGAATGACCGAGTTTGGTGTGGCTACAAGAACAAGGTGCATGTTATCCAGCCC AAGACAATGCAGATTGAGAAATCATTTGATGCCCACCCAAGGCGGGAAAGCCAGGTACGTCAGCTGGCCT GGATCGGTGATGGAGTGTGGGTCTCTATTCGCTTGGATTCTACCCTTCGGCTCTACCATGCTCACACCCA CCAGCACCTGCAGGATGTGGACATTGAGCCCTATGTTAGCAAGATGCTAGGAACCGGCAAGCTGGGCTTC TCCTTCGTGCGCATCACAGCCTTACTCATTGCAGGCAACCGTCTGTGGGTGGGCACTGGCAATGGGGTTG TCATCTCCATCCCCTTGACTGAGACTGTGGTCCTGCATCGAGGCCAGCTCCTAGGGCTCCGAGCCAACAA GACATCCCCAACATCTGGGGAGGGGACCCGCCCAGGGGGCATCATCCATGTGTATGGGGACGACAGCAGT GACAAGGCCGCCAGTAGTTTCATCCCCTACTGCTCCATGGCACAGGCTCAGCTTTGCTTCCATGGGCACC GTGATGCTGTCAAATTCTTTGTCTCTGTGCCAGGAAATGTGCTGGCCACTCTCAATGGCAGTGTGCTAGA CAGCCCATCAGAGGGCCCTGGGCCTGCTGCACCCGCTGCAGATGCTGAGGGCCAGAAGTTGAAGAATGCA CTGGTGCTGAGTGGTGGTGAAGGTTACATTGACTTCCGTATCGGAGACGGAGAGGATGATGAAACTGAGG AATGTGCCGGGGACGTGAACCAGACAAAGCCCTCGTTGTCCAAGGCTGAGCGCAGCCACATCATCGTGTG GCAGGTGTCCTACACCCCTGAG ACGCGTACGCGGCCGCTCGAG - GFP Tag - GTTTAA >MG211916 representing BC060603
Red=Cloning site Green=Tags(s) MMEIQMDEGGGVVVYQDDYCSGSVMSERVSGLAGSIYREFERLIHCYDEEVVKELMPLVVNVLENLDSVL SENQEHEVELELLREDNEQLLTQYEREKALRKQAEEKFIEFEDALEQEKKELQIQVEHYEFQTRQLELKA KNYADQISRLEERESEMKKEYNALHQRHTEMIQTYVEHIERSKMQQVGGSGQTESSLPGRSPRQSWRKSR KERPTSLNVFPLADGMCPNDEMSESGQSSAAATPSTTGTKSNTPTSSVPSAAVTPLNESLQPLGDYVSVT KNNKQAREKRNSRNMEVQVTQEMRNVSIGMGSSDEWSDVQDIIDSTPELDVCPETRLERTGSSPTQGIVN KAFGINTDSLYHELSTAGSEVIGDVDEGADLLGEFSVRDDFFGMGKEVGNLLLENSQLLETKNALNVVKN DLIAKVDQLSGEQEVLKGELEAAKQAKVKLENRIKELEEELKRVKSEAVTARREPREEVEDVSSYLCTEL DKIPMAQRRRFTRVEMARVLMERNQYKERLMELQEAVRWTEMIRASREHPSVQEKKKSTIWQFFSRLFSS SSSPPPAKRSYPSVNIHYKSPTAAGFSQRRSHALCQISAGSRPLEFFPDDDCTSSARREQKREQYRQVRE HVRNDDGRLQACGWSLPAKYKQLSPNGGQEDTRMKNVPVPVYCRPLVEKDPSTKLWCAAGVNLSGWKPHE EDSSNGPKPVPGRDPLTCDREGEGEPKSTHPSPEKKKAKETPEADATSSRVWILTSTLTTSKVVIIDANQ PGTIVDQFTVCNAHVLCISSIPAASDSDYPPGEMFLDSDVNPEDSGADGVLAGITLVGCATRCNVPRSNC SSRGDTPVLDKGQGDVATTANGKVNPSQSTEEATEATEVPDPGPSESEATTVRPGPLTEHVFTDPAPTPS SSTQPASENGSESNGTIVQPQVEPSGELSTTTSSAAPTMWLGAQNGWLYVHSAVANWKKCLHSIKLKDSV LSLVHVKGRVLVALADGTLAIFHRGEDGQWDLSNYHLMDLGHPHHSIRCMAVVNDRVWCGYKNKVHVIQP KTMQIEKSFDAHPRRESQVRQLAWIGDGVWVSIRLDSTLRLYHAHTHQHLQDVDIEPYVSKMLGTGKLGF SFVRITALLIAGNRLWVGTGNGVVISIPLTETVVLHRGQLLGLRANKTSPTSGEGTRPGGIIHVYGDDSS DKAASSFIPYCSMAQAQLCFHGHRDAVKFFVSVPGNVLATLNGSVLDSPSEGPGPAAPAADAEGQKLKNA LVLSGGEGYIDFRIGDGEDDETEECAGDVNQTKPSLSKAERSHIIVWQVSYTPE TRTRPLE - GFP Tag - V |
Restriction Sites |
SgfI-MluI
Cloning Scheme for this gene
Plasmid Map
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ACCN | BC060603 |
ORF Size | 3944 bp |
OTI Disclaimer | The molecular sequence of this clone aligns with the gene accession number as a point of reference only. However, individual transcript sequences of the same gene can differ through naturally occurring variations (e.g. polymorphisms), each with its own valid existence. This clone is substantially in agreement with the reference, but a complete review of all prevailing variants is recommended prior to use. More info |
OTI Annotation | This clone was engineered to express the complete ORF with an expression tag. Expression varies depending on the nature of the gene. |
Product Components | The ORF clone is ion-exchange column purified and shipped in a 2D barcoded Matrix tube containing 10ug of transfection-ready, dried plasmid DNA (reconstitute with 100 ul of water). |
Reconstitution | 1. Centrifuge at 5,000xg for 5min. 2. Carefully open the tube and add 100ul of sterile water to dissolve the DNA. 3. Close the tube and incubate for 10 minutes at room temperature. 4. Briefly vortex the tube and then do a quick spin (less than 5000xg) to concentrate the liquid at the bottom. 5. Store the suspended plasmid at -20°C. The DNA is stable for at least one year from date of shipping when stored at -20°C. |
Reference Data | |
RefSeq | BC060603, AAH60603 |
RefSeq Size | 5440 bp |
RefSeq ORF | 3944 bp |
Locus ID | 30957 |
Gene Summary | The JNK-interacting protein (JIP) group of scaffold proteins selectively mediates JNK signaling by aggregating specific components of the MAPK cascade to form a functional JNK signaling module. May function as a regulator of vesicle transport, through interactions with the JNK-signaling components and motor proteins (PubMed:10523642, PubMed:10629060). Promotes neuronal axon elongation in a kinesin- and JNK-dependent manner (PubMed:23576431, PubMed:25944905, PubMed:28259553). Activates cofilin at axon tips via local activation of JNK, thereby regulating filopodial dynamics and enhancing axon elongation (PubMed:23576431, PubMed:25944905, PubMed:28259553). Its binding to kinesin heavy chains (KHC), promotes kinesin-1 motility along microtubules and is essential for axon elongation and regeneration (PubMed:23576431, PubMed:25944905, PubMed:28259553). Regulates cortical neuronal migration by mediating NTRK2/TRKB anterograde axonal transport during brain development (PubMed:23576431, PubMed:25944905, PubMed:28259553). Acts as an adapter that bridges the interaction between NTRK2/TRKB and KLC1 and drives NTRK2/TRKB axonal but not dendritic anterograde transport, which is essential for subsequent BDNF-triggered signaling and filopodia formation (PubMed:23576431, PubMed:25944905, PubMed:28259553).[UniProtKB/Swiss-Prot Function] |
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