Ctnna2 (BC079648) Mouse Tagged ORF Clone

Specifications

Product Data
Type	Mouse Tagged ORF Clone
Tag	TurboGFP
Synonyms	AI481747; Catna; Catna2; cdf; chp
Vector	pCMV6-AC-GFP
E. coli Selection	Ampicillin (100 ug/mL)
Mammalian Cell Selection	Neomycin
Sequence Data	ORF Nucleotide Sequence (showhide) >MG211288 representing BC079648 Red=Cloning site Blue=ORF Green=Tags(s) TTTTGTAATACGACTCACTATAGGGCGGCCGGGAATTCGTCGACTGGATCCGGTACCGAGGAGATCTGCC GCCGCGATCGCC ATGACTTCGGCAACTTCACCTATTATTTTAAAATGGGATCCCAAAAGTTTGGAAATCCGGACACTCACAG TGGAAAGACTATTGGAGCCACTTGTGACACAGGTGACAACACTTGTCAACACAAGCAACAAAGGTCCGTC TGGTAAAAAGAAAGGGAGGTCAAAGAAAGCCCATGTGCTGGCAGCATCTGTAGAACAAGCTACTCAGAAC TTCCTGGAAAAGGGTGAACAGATCGCTAAGGAGAGCCAAGACCTCAAAGAAGAGTTAGTGGCTGCTGTAG AGGATGTGCGGAAGCAAGGTGAGACAATGCGGATTGCCTCCTCAGAGTTTGCAGATGACCCTTGCTCTTC TGTCAAGCGTGGCACCATGGTGCGTGCAGCACGGGCTCTGCTATCGGCTGTGACACGCTTGCTCATCCTG GCCGACATGGCAGATGTCATGAGGCTTTTATCGCATCTGAAAATTGTCGAGGAGGCCTTGGAAGCAGTCA AAAATGCCACAAATGAACAAGACCTTGCAAACCGATTTAAAGAGTTTGGGAAAGAGATGGTGAAACTGAA CTATGTAGCAGCAAGACGGCAGCAGGAGCTCAAGGACCCTCACTGTAGGGATGAGATGGCTGCAGCCCGT GGAGCCCTGAAGAAGAATGCCACCATGCTGTACACAGCCTCCCAAGCCTTCCTCCGGCATCCAGATGTTG CTGCTACAAGAGCCAACCGAGATTATGTATTTAAACAAGTCCAAGAGGCCATAGCTGGCATCTCCAGTGC TGCTCAGGCCACCTCCCCCACCGATGAAGCCAAAGGCCACACAGGCATCGGCGAGCTGGCTGCAGCCCTG AATGAGTTTGATAATAAGATCATCCTGGACCCCATGACATTCAGCGAGGCCAGGTTCCGACCATCCCTGG AGGAGAGACTGGAGAGCATCATCAGTGGGGCTGCTCTCATGGCAGATTCCTCCTGCACACGTGATGACCG CCGTGAGCGTATTGTGGCCGAGTGCAATGCAGTTCGACAGGCACTCCAGGACCTGCTAAGCGAGTACATG AATAACACTGGAAGGAAAGAGAAAGGAGACCCTCTCAACATTGCGATTGACAAGATGACCAAGAAAACAA GAGATCTGAGGAGACAGCTTCGGAAAGCTGTGATGGATCACATCTCAGATTCTTTCTTGGAAACCAATGT CCCCTTGCTGGTTCTCATTGAGGCTGCGAAGAGCGGGAATGAGAAGGAGGTGAAGGAATACGCCCAAGTT TTCCGTGAACATGCCAACAAGCTGGTGGAGGTTGCCAATTTGGCTTGTTCCATCTCCAACAATGAGGAAG GGGTGAAATTAGTCAGAATGGCAGCCACCCAGATTGACAGCCTGTGTCCCCAAGTCATTAATGCTGCCCT CACACTGGCTGCTCGGCCACAGAGTAAAGTTGCTCAGGACAACATGGATGTCTTCAAAGACCAGTGGGAA AAGCAAGTCCGTGTGCTCACTGAGGCAGTGGATGACATCACCTCTGTGGATGACTTCCTCTCTGTCTCAG AAAACCATATCTTGGAGGATGTGAACAAATGTGTGATTGCCCTGCAAGAGGGAGATGTGGACACACTGGA TCGCACAGCTGGGGCCATACGGGGCCGGGCAGCCCGGGTCATTCACATCATCAATGCAGAGATCGAGAAC TATGAAGCTGGGGTCTATACAGAGAAAGTGCTGGAAGCCACAAAATTGCTTTCAGAAACAGTGATGCCAC GCTTTGCTGAACAAGTTGAGGTGGCCATCGAAGCCCTGAGCGCCAATGTCCCTCAGCCATTCGAGGAGAA CGAGTTCATCGATGCCTCGCGCCTGGTGTATGACGGTGTTCGGGACATCAGAAAGGCTGTGCTGATGATC AGGACTCCAGAAGAGCTAGAAGATGATTCCGACTTTGAGCAAGAGGATTATGTGCGGAGTCGGACAAGTG TTCAGACAGAGGACGACCAGCTCATTGCTGGACAGAGTGCACGGGCCATCATGGCGCAACTACCACAGGA GGAGAAAGCAAAAATAGCTGAACAGGTGGAGATTTTCCACCAAGAAAAAAGCAAGCTGGATGCTGAAGTG GCCAAGTGGGATGACAGCGGCAATGACATCATTGTGCTGGCCAAGCAGATGTGTATGATCATGATGGAGA TGACAGACTTCACAAGAGGCAAAGGCCCACTGAAAAATACATCTGATGTCATTAATGCTGCCAAGAAGAT TGCAGAAGCAGGCTCTCGAATGGACAAATTAGCGCGCGCTGTGGCTGATCAGTGTCCTGATTCAGCATGT AAGCAGGATTTATTAGCCTACCTTCAGCGGATTGCTTTGTACTGCCATCAGCTTAACATCTGCAGCAAAG TGAAGGCCGAGGTTCAGAACCTAGGAGGAGAGCTCATTGTGTCAGGGACAGGAGTTCAGAGCACTTTCAC TACCTTTTATGAGGTAGATTGTGATGTCATAGATGGGGGCAGGGCTAGTCAACTTTCTACCCACCTCCCA ACCTGTGCTGAGGGAGCTCCAATCGGGAGTGGAAGCAGTGACTCCTCCATGCTGGACAGTGCTACATCAC TCATCCAGGCAGCCAAAAACCTGATGAATGCTGTTGTCCTCACGGTGAAAGCGTCTTATGTAGCCTCAAC TAAATACCAGAAGGTCTATGGAACAGCAGCTGTCAACTCTCCAGTTGTGTCTTGGAAGATGAAGGCTCCT GAAAAGAAGCCCCTTGTGAAGAGAGAAAAGCCTGAAGAATTCCAGACAAGAGTTAGACGGGGGTCTCAAA AGAAACACATTTCACCTGTGCAGGCTTTAAGTGAATTCAAGGCAATGGATTCCTTC ACGCGTACGCGGCCGCTCGAG - GFP Tag - GTTTAA Protein Sequence (showhide) >MG211288 representing BC079648 Red=Cloning site Green=Tags(s) MTSATSPIILKWDPKSLEIRTLTVERLLEPLVTQVTTLVNTSNKGPSGKKKGRSKKAHVLAASVEQATQN FLEKGEQIAKESQDLKEELVAAVEDVRKQGETMRIASSEFADDPCSSVKRGTMVRAARALLSAVTRLLIL ADMADVMRLLSHLKIVEEALEAVKNATNEQDLANRFKEFGKEMVKLNYVAARRQQELKDPHCRDEMAAAR GALKKNATMLYTASQAFLRHPDVAATRANRDYVFKQVQEAIAGISSAAQATSPTDEAKGHTGIGELAAAL NEFDNKIILDPMTFSEARFRPSLEERLESIISGAALMADSSCTRDDRRERIVAECNAVRQALQDLLSEYM NNTGRKEKGDPLNIAIDKMTKKTRDLRRQLRKAVMDHISDSFLETNVPLLVLIEAAKSGNEKEVKEYAQV FREHANKLVEVANLACSISNNEEGVKLVRMAATQIDSLCPQVINAALTLAARPQSKVAQDNMDVFKDQWE KQVRVLTEAVDDITSVDDFLSVSENHILEDVNKCVIALQEGDVDTLDRTAGAIRGRAARVIHIINAEIEN YEAGVYTEKVLEATKLLSETVMPRFAEQVEVAIEALSANVPQPFEENEFIDASRLVYDGVRDIRKAVLMI RTPEELEDDSDFEQEDYVRSRTSVQTEDDQLIAGQSARAIMAQLPQEEKAKIAEQVEIFHQEKSKLDAEV AKWDDSGNDIIVLAKQMCMIMMEMTDFTRGKGPLKNTSDVINAAKKIAEAGSRMDKLARAVADQCPDSAC KQDLLAYLQRIALYCHQLNICSKVKAEVQNLGGELIVSGTGVQSTFTTFYEVDCDVIDGGRASQLSTHLP TCAEGAPIGSGSSDSSMLDSATSLIQAAKNLMNAVVLTVKASYVASTKYQKVYGTAAVNSPVVSWKMKAP EKKPLVKREKPEEFQTRVRRGSQKKHISPVQALSEFKAMDSF TRTRPLE - GFP Tag - V
Restriction Sites	SgfI-MluI      Cloning Scheme for this gene      Plasmid Map
ACCN	BC079648
ORF Size	2858 bp
OTI Disclaimer	The molecular sequence of this clone aligns with the gene accession number as a point of reference only. However, individual transcript sequences of the same gene can differ through naturally occurring variations (e.g. polymorphisms), each with its own valid existence. This clone is substantially in agreement with the reference, but a complete review of all prevailing variants is recommended prior to use. More info
OTI Annotation	This clone was engineered to express the complete ORF with an expression tag. Expression varies depending on the nature of the gene.
Product Components	The ORF clone is ion-exchange column purified and shipped in a 2D barcoded Matrix tube containing 10ug of transfection-ready, dried plasmid DNA (reconstitute with 100 ul of water).
Reconstitution	1. Centrifuge at 5,000xg for 5min. 2. Carefully open the tube and add 100ul of sterile water to dissolve the DNA. 3. Close the tube and incubate for 10 minutes at room temperature. 4. Briefly vortex the tube and then do a quick spin (less than 5000xg) to concentrate the liquid at the bottom. 5. Store the suspended plasmid at -20°C. The DNA is stable for at least one year from date of shipping when stored at -20°C.
Note	Plasmids are not sterile.  For experiments where strict sterility is required, filtration with 0.22um filter is required.
Reference Data
RefSeq	BC079648, AAH79648
RefSeq Size	4062 bp
RefSeq ORF	2858 bp
Locus ID	12386
Gene Summary	May function as a linker between cadherin adhesion receptors and the cytoskeleton to regulate cell-cell adhesion and differentiation in the nervous system (PubMed:12123610, PubMed:15034585). Required for proper regulation of cortical neuronal migration and neurite growth. It acts as negative regulator of Arp2/3 complex activity and Arp2/3-mediated actin polymerization. It thereby suppresses excessive actin branching which would impair neurite growth and stability (By similarity). Regulates morphological plasticity of synapses and cerebellar and hippocampal lamination during development. Functions in the control of startle modulation (PubMed:12089526).[UniProtKB/Swiss-Prot Function]

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