Fkbp8 (NM_001199631) Mouse Untagged Clone

Specifications

Product Data
Type	Mouse Untagged Clone
Tag	Tag Free
Synonyms	38kDa; FKBP-8; FKBP-38; Fkbp38
Vector	pCMV6-Entry
E. coli Selection	Kanamycin (25 ug/mL)
Mammalian Cell Selection	Neomycin
Sequence Data	Fully Sequenced ORF (showhide) >MC227509 representing NM_001199631 Red=Cloning site Blue=ORF Orange=Stop codon TTTTGTAATACGACTCACTATAGGGCGGCCGGGAATTCGTCGACTGGATCCGGTACCGAGGAGATCTGCC GCCGCGATCGCC ATGGCGTCTTGGGCTGAGCCCTCTGAGCCTGCTGCCCTGCGACTTCCTGGGGCCCCACTGCTGGAGGGCT TTGAGGTGCTCGATGGGGTTGATGATGCAGAGGAGGAAGATGACCTAAGTGGGCTGCCACCACTAGAGGA CATGGGACAGCCTACAGTGGAGGAGGCTGAGCAGCCTGGAGCCCTGGCTCGGGAGTTCCTGGCAGCCACA GAGCCTGAGCCAGCCCCAGCCCCAGCCCCGGAAGAGTGGCTGGACATTCTGGGGAACGGATTGCTGCGGA TGAAGACACTGGTCCCAGGCCCGAAAGGCTCTAGCCGCCCACTCAAGGGCCAGGTGGTGACCGTTCACCT GCAGATGTCCCTGGAGAATGGCACCCGTGTACAGGAAGAGCCTGAACTGGCCTTCACGCTGGGAGACTGC GATGTTATCCAGGCCCTGGACCTCAGTGTCCCGCTCATGGATGTGGGCGAGACAGCCATGGTTACCGCTG ACTCCAAGTACTGCTACGGCCCCCAGGGCAGCAGGAGCCCATACATCCCCCCCCACGCAGCCCTGTGCCT GGAAGTCACCCTGAAGACGGCAGAGGATGGACCCGACCTGGAGATGCTGAGTGGGCAGGAGCGCGTGGCC CTGGCCAACCGCAAGCGGGAGTGTGGCAATGCCCACTACCAGCGTGCCGACTTTGTGCTGGCCGCCAATT CCTATGACCTGGCCATCAAGGCTATCACCTCCAACACCAAAGTGGACATGACTTGTGAGGAGGAAGAGGA GCTGCTACAGCTGAAGGTCAAGTGTCTGAACAACCTTGCGGCCTCACAGCTGAAGCTGGACCACTACCGA GCAGCTCTGCGCTCCTGTAGCCAGGTGCTGGAGCACCAGCCGGACAACATCAAGGCACTGTTCCGCAAGG GCAAGGTGCTGGCTCAGCAAGGTGAATATAGTGAGGCCATCCCAATCCTGAGGGCTGCCCTGAAGCTGGA ACCTTCCAACAAGACGATCCACGCAGAGCTCTCAAAGCTGGTAAAGAAGCGTGCTGCACAGCGGAGCACA GAGACCGCCCTGTACCGAAAGATGCTAGGCAACCCCAGCCGGCTGCCTGCCAAGTGTCCGGGAAAGGGGG CCTGGTCCATCCCGTGGAAATGGCTGTTTGGGGCGACTGCCGTGGCCCTGGGGGGCGTGGCTCTCTCTGT GGTCATTGCTGCCAGGAACTGA ACGCGTACGCGGCCGCTCGAGCAGAAACTCATCTCAGAAGAGGATCTGGCAGCAAATGATATCCTGGATT ACAAGGATGACGACGATAAGGTTTAA
Restriction Sites	SgfI-MluI
ACCN	NM_001199631
Insert Size	1212 bp
OTI Disclaimer	Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP).
OTI Annotation	Clone contains native stop codon, and expresses the complete ORF without any c-terminal tag.
Product Components	The ORF clone is ion-exchange column purified and shipped in a 2D barcoded Matrix tube containing 10ug of transfection-ready, dried plasmid DNA (reconstitute with 100 ul of water).
Reconstitution	1. Centrifuge at 5,000xg for 5min. 2. Carefully open the tube and add 100ul of sterile water to dissolve the DNA. 3. Close the tube and incubate for 10 minutes at room temperature. 4. Briefly vortex the tube and then do a quick spin (less than 5000xg) to concentrate the liquid at the bottom. 5. Store the suspended plasmid at -20°C. The DNA is stable for at least one year from date of shipping when stored at -20°C.
Note	Plasmids are not sterile.  For experiments where strict sterility is required, filtration with 0.22um filter is required.
Reference Data
RefSeq	NM_001199631.1, NP_001186560.1
RefSeq Size	1826 bp
RefSeq ORF	1212 bp
Locus ID	14232
UniProt ID	O35465
Gene Summary	Constitutively inactive PPiase, which becomes active when bound to calmodulin and calcium. Seems to act as a chaperone for BCL2, targets it to the mitochondria and modulates its phosphorylation state. The BCL2/FKBP8/calmodulin/calcium complex probably interferes with the binding of BCL2 to its targets. The active form of FKBP8 may therefore play a role in the regulation of apoptosis (By similarity). Required for normal embryonic development.[UniProtKB/Swiss-Prot Function] Transcript Variant: This variant (3) contains a different segment for its 5' UTR, compared to variant 1. Variants 1 and 3 encode the same protein (isoform a). Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments.

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