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Trpm4 (NM_175130) Mouse Untagged Clone
CAT＃: MC223963
Trpm4 (untagged) - Mouse transient receptor potential cation channel, subfamily M, member 4 (Trpm4), (10ug)
CNY 15,580.00
货期*
7周
规格
Product images
经常一起买 (3)
Specifications
| Product Data | |
| Type | Mouse Untagged Clone |
| Tag | Tag Free |
| Synonyms | 1110030C19Rik; AW047689; LTrpC-4; LTRPC4; TRPM4B |
| Vector | pCMV6-Entry |
| E. coli Selection | Kanamycin (25 ug/mL) |
| Mammalian Cell Selection | Neomycin |
| Sequence Data |
>MC223963 representing NM_175130
Red=Cloning site Blue=ORF Orange=Stop codon TTTTGTAATACGACTCACTATAGGGCGGCCGGGAATTCGTCGACTGGATCCGGTACCGAGGAGATCTGCC GCCGCGATCGCC ATGGTGGGGCCGGAGAAGGAGCAGAGCTGGATCCCTAAGATCTTCAGGAAGAAGGTGTGCACGACGTTCA TAGTGGACCTCTCCGATGATGCGGGAGGGACCTTGTGCCAGTGTGGGCAACCTCGGGATGCCCACCCTTC TGTGGCTGTGGAGGATGCCTTTGGGGCAGCCGTAGTTACCGAGTGGAACAGTGATGAGCACACCACGGAG AAGCCCACAGATGCCTATGGGGACCTGGACTTCACGTACTCTGGCCGAAAGCACAGCAACTTTCTCCGGC TGTCTGACCGCACGGATCCGGCCACTGTGTACAGTCTCGTTACCCGCTCTTGGGGCTTTCGTGCCCCAAA CTTGGTGGTGTCGGTGCTGGGGGGGTCGGGGGGCCCCGTGCTCCAGACCTGGCTGCAGGACCTTCTGCGT CGCGGGCTGGTGAGAGCCGCCCAGAGCACAGGGGCCTGGATCGTCACTGGGGGACTGCACACAGGCATTG GCCGGCACGTGGGTGTGGCTGTAAGGGACCACCAGACAGCCAGCACTGGGAGCAGCAAGGTGGTGGCCAT GGGTGTGGCCCCCTGGGGAGTGGTCCGGAACAGAGACATGCTGATCAACCCCAAGGGCTCATTCCCCGCA AGGTACCGGTGGCGTGGTGACCCTGAGGATGGTGTTGAGTTCCCCCTGGACTATAACTATTCTGCTTTCT TCTTGGTGGATGATGGCACCTATGGCCGCCTGGGTGGTGAGAACCGCTTCCGCCTTCGGTTTGAGTCCTA TGTGGCTCAGCAGAAGACCGGAGTGGGAGGGACTGGAATTGACATCCCAGTGCTCCTTCTTCTCATCGAT GGAGATGAGAAGATGTTAAAGCGGATAGAGGATGCCACCCAAGCTCAGCTCCCCTGCCTCTTGGTGGCGG GCTCTGGGGGTGCTGCAGACTGTCTGGTGGAGACCCTGGAAGATACTCTGGCCCCAGGGAGTGGGGGACT TAGGCGAGGCGAAGCCCGGGATCGGATTAGGCGATACTTCCCTAAAGGAGACCCTGAGGTTCTTCAGGCC CAGGTAGAGAGGATCATGACCCGAAAGGAGTTGCTGACGGTCTATTCATCAGAAGACGGCTCCGAGGAGT TTGAGACTATCGTTTTGAGGGCTCTTGTGAAAGCCTGTGGGAGCTCTGAGGCCTCAGCCTACCTGGATGA GCTGCGTTTGGCTGTGGCTTGGAACCGCGTGGACATCGCCCAAAGTGAACTTTTCCGTGGGGACATCCAA TGGCGGTCCTTCCACCTGGAGGCATCTCTCATGGATGCTCTGCTGAATGACCGGCCTGAATTTGTGCGCC TGCTCATCTCCCATGGCCTTAGCCTGGGACACTTCCTGACCCCCGTGCGTCTGGCCCAGCTGTACAGCGC GGTGTCCCCTAACTCACTGATCCGAAATCTTCTGGACCAGGCGTCCCATGCTAGTAGCAGCAAATCCCCT CCTGTAAATGGAACTGTAGAGCTCCGGCCTCCCAATGTGGGGCAAGTGCTGAGGACTCTGTTGGGAGAAA CGTGTGCACCACGGTACCCTGCCAGGAACACCCGAGACTCCTATCTGGGCCAGGACCACAGAGAGAATGA CTCTCTGCTTATGGACTGGGCCAACAAGCAACCATCAACGGATGCAAGCTTTGAACAAGCCCCCTGGAGT GACCTGCTTATTTGGGCTCTGTTGCTGAACCGGGCCCAGATGGCTATCTATTTCTGGGAGAAGGGCTCCA ACTCAGTGGCCTCTGCTCTTGGGGCTTGTCTTTTACTCCGAGTGATGGCTCGCCTAGAGTCGGAGGCTGA GGAGGCCGCGCGGCGGAAGGATCTTGCTGCCACGTTTGAAAGCATGAGCGTGGACCTCTTTGGAGAGTGT TACCACAACAGTGAAGAGCGAGCAGCCCGCCTTCTTCTGCGCCGCTGTCCCCTCTGGGGAGAGGCCACCT GCCTCCAGCTTGCCATGCAGGCTGATGCCCGAGCGTTCTTTGCCCAGGATGGAGTCCAGTCTCTTCTGAC ACAGAAGTGGTGGGGGGAGATGGACAGCACAACTCCCATCTGGGCCCTGCTTCTCGCCTTCTTCTGCCCG CCTCTCATCTACACCAACCTTATCGTCTTCAGGAAGTCAGAGGAGGAGCCCACACAGAAGGATCTTGACT TTGATATGGACAGCAGCATCAATGGAGCAGGTCCTCCTGGGACTGTAGAACCCTCTGCAAAGGTGGCCCT TGAGAGGCGGCAGCGGCGACGGCCAGGACGTGCCCTCTGCTGTGGCAAGTTCTCCAAGCGCTGGTCGGAC TTCTGGGGTGCCCCAGTGACTGCCTTCCTGGGTAATGTGGTCAGTTACCTGCTGTTCCTGCTGCTGTTTG CCCACGTGTTGCTGGTGGATTTCCAGCCCACAAAGCCAAGTGTCTCCGAGCTGCTGCTGTACTTCTGGGC CTTCACGTTGCTGTGCGAGGAGCTGCGCCAGGGCCTGGGTGGTGGCTGGGGTAGCCTGGCCAGTGGGGGA CGTGGTCCGGACAGAGCTCCCCTGCGCCATCGGCTGCACCTCTACCTCTCAGATACCTGGAACCAATGTG ACCTGCTGGCACTCACCTGCTTCCTGCTGGGCGTAGGCTGCCGGCTGACCCCTGGGCTCTTTGACTTGGG ACGCACCGTCCTCTGCCTTGACTTCATGATCTTCACACTGCGCCTGCTGCACATCTTCACGGTGAACAAG CAGCTGGGGCCCAAGATTGTCATAGTGAGCAAAATGATGAAGGATGTATTCTTCTTCCTCTTCTTCCTCT GCGTGTGGCTTGTAGCTTATGGGGTGGCCACAGAGGGGATCCTGAGGCCCCAGGACCGCAGTCTACCGAG TATCCTGCGCAGGGTCTTCTACCGACCGTATCTGCAGATCTTCGGACAAATTCCCCAGGAGGAAATGGAC GTGGCCCTCATGATTCCAGGTAACTGCTCAATGGAGCGGGGCTCCTGGGCTCATCCGGAGGGGCCCGTCG CAGGCTCCTGTGTGTCCCAGTATGCCAACTGGCTGGTGGTGTTGCTCCTTATCGTCTTCTTGCTGGTGGC CAATATCCTGTTGCTCAACCTGCTCATCGCCATGTTCAGCTACACCTTCAGCAAAGTGCACGGCAACAGC GACCTCTACTGGAAGGCACAGCGCTACAGCCTCATCCGGGAATTCCATTCGAGGCCTGCCCTGGCCCCAC CCCTCATCATCATCTCTCATGTGCGCCTCCTCATCAAGTGGCTGCGCAGGTGTCGCAGGTGTCGCAGGGC TAACTTGCCCGCCTCCCCAGTCTTCGAGCACTTCCGTGTCTGTCTCTCTAAGGAAGCAGAGCGGAAGCTG CTGACTTGGGAGTCTGTGCACAAAGAGAACTTCCTGTTGGCACAAGCTCGGGACAAGCGAGACAGTGACT CGGAGCGTTTGAAACGCACGTCTCAGAAGGTGGACACTGCACTGAAGCAGCTGGGACAGATCAGAGAGTA CGATCGGCGTCTGAGGGGGCTGGAGAGAGAGGTCCAACACTGTTCTCGAGTCCTGACTTGGATGGCTGAG GCCCTTAGCCACTCTGCCTTGCTGCCTCCAGGGGCCCCACCCCCTCCGAGCCCCACTGGTTCCAAAGACT GA ACGCGTACGCGGCCGCTCGAGCAGAAACTCATCTCAGAAGAGGATCTGGCAGCAAATGATATCCTGGATT ACAAGGATGACGACGATAAGGTTTAA |
| Restriction Sites | SgfI-MluI |
| ACCN | NM_175130 |
| Insert Size | 3642 bp |
| OTI Disclaimer | Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP). |
| Product Components | The ORF clone is ion-exchange column purified and shipped in a 2D barcoded Matrix tube containing 10ug of transfection-ready, dried plasmid DNA (reconstitute with 100 ul of water). |
| Reconstitution | 1. Centrifuge at 5,000xg for 5min. 2. Carefully open the tube and add 100ul of sterile water to dissolve the DNA. 3. Close the tube and incubate for 10 minutes at room temperature. 4. Briefly vortex the tube and then do a quick spin (less than 5000xg) to concentrate the liquid at the bottom. 5. Store the suspended plasmid at -20°C. The DNA is stable for at least one year from date of shipping when stored at -20°C. |
| Note | Plasmids are not sterile. For experiments where strict sterility is required, filtration with 0.22um filter is required. |
| Reference Data | |
| RefSeq | NM_175130.4, NP_780339.2 |
| RefSeq Size | 4245 bp |
| RefSeq ORF | 3642 bp |
| Locus ID | 68667 |
| UniProt ID | Q7TN37 |
| Gene Summary | Calcium-activated non selective (CAN) cation channel that mediates membrane depolarization. While it is activated by increase in intracellular Ca(2+), it is impermeable to it (PubMed:17188667, PubMed:29211714). Mediates transport of monovalent cations (Na(+) > K(+) > Cs(+) > Li(+)), leading to depolarize the membrane. It thereby plays a central role in cadiomyocytes, neurons from entorhinal cortex, dorsal root and vomeronasal neurons, endocrine pancreas cells, kidney epithelial cells, cochlea hair cells etc. Participates in T-cell activation by modulating Ca(2+) oscillations after T lymphocyte activation, which is required for NFAT-dependent IL2 production. Involved in myogenic constriction of cerebral arteries. Controls insulin secretion in pancreatic beta-cells. May also be involved in pacemaking or could cause irregular electrical activity under conditions of Ca(2+) overload. Affects T-helper 1 (Th1) and T-helper 2 (Th2) cell motility and cytokine production through differential regulation of calcium signaling and NFATC1 localization. Enhances cell proliferation through up-regulation of the beta-catenin signaling pathway (By similarity). Essential for the migration but not the maturation of dendritic cells (PubMed:18758465).[UniProtKB/Swiss-Prot Function] |
Documents
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| SDS |
Resources
Other Versions
| SKU | Description | Size | Price |
|---|---|---|---|
| MR211808 | Trpm4 (Myc-DDK-tagged) - Mouse transient receptor potential cation channel, subfamily M, member 4 (Trpm4) |
CNY 8,448.00 |
|
| MR211808L3 | Lenti ORF clone of Trpm4 (Myc-DDK-tagged) - Mouse transient receptor potential cation channel, subfamily M, member 4 (Trpm4) |
CNY 11,500.00 |
|
| MR211808L4 | Lenti ORF clone of Trpm4 (mGFP-tagged) - Mouse transient receptor potential cation channel, subfamily M, member 4 (Trpm4) |
CNY 11,500.00 |
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