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Axl (NM_001190974) Mouse Untagged Clone
CAT＃: MC222378
Axl (untagged) - Mouse AXL receptor tyrosine kinase (Axl), transcript variant 2, (10ug)
CNY 11,310.00
Product images
Specifications
| Product Data | |
| Type | Mouse Untagged Clone |
| Tag | Tag Free |
| Synonyms | AI323647; Ark; Tyro7; Ufo |
| Vector | pCMV6-Entry |
| E. coli Selection | Kanamycin (25 ug/mL) |
| Mammalian Cell Selection | Neomycin |
| Sequence Data |
>MC222378 representing NM_001190974
Red=Cloning site Blue=ORF Orange=Stop codon TTTTGTAATACGACTCACTATAGGGCGGCCGGGAATTCGTCGACTGGATCCGGTACCGAGGAGATCTGCC GCCGCGATCGCC ATGGGCAGGGTCCCGCTGGCCTGGTGGTTGGCGCTGTGCTGCTGGGGGTGTGCAGCCCATAAGGACACAC AGACCGAGGCTGGCAGCCCGTTTGTGGGGAACCCAGGGAATATCACAGGTGCCAGAGGACTCACGGGGAC ACTTCGGTGTGAGCTCCAGGTTCAGGGGGAACCCCCTGAGGTGGTGTGGCTTCGAGATGGACAGATCCTA GAACTGGCTGATAACACCCAGACCCAGGTGCCTCTGGGCGAAGACTGGCAAGATGAATGGAAAGTTGTCA GTCAGCTCAGAATCTCAGCCCTGCAACTTTCAGATGCAGGGGAGTACCAGTGTATGGTGCATCTAGAAGG ACGGACCTTTGTGTCTCAGCCGGGCTTTGTAGGGCTGGAAGGTCTCCCGTACTTCCTGGAGGAGCCTGAG GACAAAGCTGTGCCTGCCAACACCCCTTTCAACCTAAGCTGCCAGGCCCAGGGACCCCCGGAACCCGTGA CCCTACTCTGGCTTCAAGATGCTGTCCCCCTGGCCCCAGTCACAGGACACAGCTCCCAGCACAGTCTGCA AACTCCAGGCCTGAACAAGACATCTTCTTTCTCATGTGAAGCCCACAATGCCAAGGGAGTCACCACCTCC CGCACAGCCACCATCACAGTGCTCCCCCAGAGGCCTCACCATCTCCACGTGGTTTCCAGACAACCTACGG AGCTAGAGGTAGCTTGGACCCCTGGCCTGAGTGGCATCTACCCGCTCACCCACTGCAACCTGCAGGCCGT GCTGTCAGACGATGGGGTGGGTATCTGGCTGGGAAAGTCAGATCCTCCTGAAGACCCCCTCACCTTGCAA GTATCAGTGCCCCCCCACCAGCTTCGGCTGGAAAAGCTCCTTCCTCACACCCCGTATCACATCCGGATAT CCTGCAGCAGCAGCCAGGGCCCCTCACCTTGGACCCACTGGCTTCCTGTGGAGACCACAGAGGGAGTGCC CTTGGGTCCCCCTGAGAACGTTAGCGCCATGCGGAATGGGAGCCAGGTCCTCGTGCGTTGGCAGGAGCCA AGGGTGCCCCTGCAAGGCACCCTGTTAGGGTACCGGCTGGCATATCGAGGCCAGGACACCCCCGAGGTAC TTATGGATATAGGGCTAACTCGAGAGGTGACCTTGGAACTGCGGGGGGACAGGCCTGTGGCTAACCTGAC TGTGTCTGTGACAGCCTATACCTCGGCTGGGGATGGGCCCTGGAGCCTTCCTGTGCCCCTAGAGCCCTGG CGCCCAGTGAGTGAACCCCCACCTCGCGCCTTCTCGTGGCCTTGGTGGTATGTACTGCTGGGAGCACTTG TGGCTGCCGCCTGCGTCCTCATCTTGGCCCTGTTCCTTGTCCATCGGAGGAAGAAGGAGACTCGATATGG GGAGGTGTTTGAGCCAACCGTGGAAAGAGGTGAACTGGTAGTCAGGTACCGTGTCCGAAAGTCCTACAGC CGGCGGACCACTGAAGCCACCTTGAACAGTCTGGGCATCAGTGAAGAGCTGAAGGAGAAACTACGAGACG TCATGGTAGATCGGCATAAGGTGGCCTTGGGGAAGACCCTGGGAGAAGGAGAATTTGGCGCTGTGATGGA AGGTCAGCTCAATCAGGATGACTCCATCCTCAAGGTCGCTGTGAAGACCATGAAAATTGCCATCTGCACA AGATCAGAGCTGGAGGATTTCCTGAGTGAAGCTGTCTGCATGAAGGAATTTGACCACCCCAACGTCATGA GGCTCATTGGCGTCTGTTTTCAGGGCTCTGACAGAGAGGGTTTCCCAGAACCTGTGGTCATCTTGCCTTT CATGAAACACGGAGACCTACACAGTTTCCTCCTGTACTCCCGGCTCGGGGACCAGCCAGTGTTCCTGCCC ACTCAGATGCTAGTGAAGTTCATGGCCGACATTGCCAGTGGTATGGAGTACCTGAGTACCAAGAGATTCA TACATCGGGACCTGGCTGCCAGGAACTGCATGCTGAATGAGAACATGTCCGTGTGTGTGGCAGACTTCGG GCTCTCCAAGAAGATCTACAACGGGGATTACTACCGCCAAGGGCGCATTGCCAAGATGCCAGTCAAGTGG ATTGCTATTGAGAGTCTGGCAGATCGGGTCTACACCAGCAAGAGCGATGTGTGGTCCTTCGGTGTGACAA TGTGGGAGATCGCCACCCGAGGCCAAACTCCCTATCCAGGGGTGGAGAACAGTGAGATTTACGACTACCT GCGTCAAGGAAATCGGCTGAAACAGCCTGTGGACTGTCTGGACGGCCTGTATGCCCTGATGTCTCGGTGC TGGGAACTGAACCCTCGAGACCGGCCAAGTTTTGCGGAGCTCCGGGAAGACTTGGAGAACACACTGAAGG CTCTGCCCCCTGCTCAGGAGCCAGATGAAATCCTCTATGTCAACATGGATGAGGGCGGAAGCCACCTTGA ACCCCGTGGGGCTGCTGGAGGAGCTGACCCCCCAACCCAACCTGATCCTAAGGATTCCTGTAGCTGTCTC ACTGCAGCTGACGTCCACTCAGCTGGACGCTATGTCCTTTGTCCTTCTACAGCCCCAGGACCCACTCTGT CTGCTGACAGAGGCTGCCCAGCACCTCCAGGGCAGGAGGACGGAGCCTGA ACGCGTACGCGGCCGCTCGAGCAGAAACTCATCTCAGAAGAGGATCTGGCAGCAAATGATATCCTGGATT ACAAGGATGACGACGATAAGGTTTAA |
| Restriction Sites | SgfI-MluI |
| ACCN | NM_001190974 |
| Insert Size | 2640 bp |
| OTI Disclaimer | Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP). |
| Product Components | The ORF clone is ion-exchange column purified and shipped in a 2D barcoded Matrix tube containing 10ug of transfection-ready, dried plasmid DNA (reconstitute with 100 ul of water). |
| Reconstitution | 1. Centrifuge at 5,000xg for 5min. 2. Carefully open the tube and add 100ul of sterile water to dissolve the DNA. 3. Close the tube and incubate for 10 minutes at room temperature. 4. Briefly vortex the tube and then do a quick spin (less than 5000xg) to concentrate the liquid at the bottom. 5. Store the suspended plasmid at -20°C. The DNA is stable for at least one year from date of shipping when stored at -20°C. |
| Reference Data | |
| RefSeq | NM_001190974.1, NP_001177903.1 |
| RefSeq Size | 5057 bp |
| RefSeq ORF | 2640 bp |
| Locus ID | 26362 |
| Gene Summary | Receptor tyrosine kinase that transduces signals from the extracellular matrix into the cytoplasm by binding growth factor GAS6 and which is thus regulating many physiological processes including cell survival, cell proliferation, migration and differentiation. Ligand binding at the cell surface induces dimerization and autophosphorylation of AXL. Following activation by ligand, ALX binds and induces tyrosine phosphorylation of PI3-kinase subunits PIK3R1, PIK3R2 and PIK3R3; but also GRB2, PLCG1, LCK and PTPN11. Other downstream substrate candidates for AXL are CBL, NCK2, SOCS1 and TNS2. Recruitment of GRB2 and phosphatidylinositol 3 kinase regulatory subunits by AXL leads to the downstream activation of the AKT kinase. GAS6/AXL signaling plays a role in various processes such as endothelial cell survival during acidification by preventing apoptosis, optimal cytokine signaling during human natural killer cell development, hepatic regeneration, gonadotropin-releasing hormone neuron survival and migration, platelet activation, or regulation of thrombotic responses. Plays also an important role in inhibition of Toll-like receptors (TLRs)-mediated innate immune response.[UniProtKB/Swiss-Prot Function] Transcript Variant: This variant (2) lacks an in-frame exon in the coding region, compared to variant 1. The resulting protein (isoform 2) is shorter, compared to isoform 1. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. |
Documents
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Resources
Other Versions
| SKU | Description | Size | Price |
|---|---|---|---|
| MG222556 | Axl (tGFP-tagged) - Mouse AXL receptor tyrosine kinase (Axl) transcript variant 2, (10ug) |
CNY 9,600.00 |
|
| MR222556 | Axl (Myc-DDK-tagged) - Mouse AXL receptor tyrosine kinase (Axl), transcript variant 2 |
CNY 8,740.00 |
|
| MR222556L3 | Lenti ORF clone of Axl (Myc-DDK-tagged) - Mouse AXL receptor tyrosine kinase (Axl), transcript variant 2 |
CNY 10,640.00 |
|
| MR222556L4 | Lenti ORF clone of Axl (mGFP-tagged) - Mouse AXL receptor tyrosine kinase (Axl), transcript variant 2 |
CNY 10,640.00 |
