Foxo3 (NM_019740) Mouse Untagged Clone

CAT#: MC220343

Foxo3 (untagged) - Mouse forkhead box O3 (Foxo3), (10ug)



  "NM_019740" in other vectors (4)

CNY 8,650.00


货期*
5周

规格
    • 10 ug

Product images

经常一起买 (3)
FOXO3A Rabbit polyclonal Antibody
    • 100 ul

CNY 1,999.00
CNY 3,280.00

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TurboFectin Transfection Reagent (1 mL in 1 vial)
    • 1 ml in 1 vial

CNY 4,090.00


Forward sequencing primer VP1.5, Reverse sequencing primer XL39, 100pmoles each
    • 100 pmol

CNY 480.00

Specifications

Product Data
Type Mouse Untagged Clone
Tag Tag Free
Synonyms 1110048B16Rik; 2010203A17Rik; C76856; Fkhr2; FKHRL1; Foxo3a
Vector pCMV6-Entry
E. coli Selection Kanamycin (25 ug/mL)
Mammalian Cell Selection Neomycin
Sequence Data
>MC220343 representing NM_019740
Red=Cloning site Blue=ORF Orange=Stop codon

TTTTGTAATACGACTCACTATAGGGCGGCCGGGAATTCGTCGACTGGATCCGGTACCGAGGAGATCTGCC
GCCGCGATCGCC

ATGGCAGAGGCACCAGCCTCCCCGGTCCCGCTCTCTCCGCTCGAAGTGGAGCTGGACCCAGAGTTCGAGC
CACAGAGTCGGCCACGCTCCTGTACGTGGCCCCTGCAGAGGCCGGAGCTGCAGGCGAGCCCGGCCAAGCC
CTCGGGGGAGACGGCCGCAGACTCCATGATCCCCGAGGAGGACGACGATGAAGACGACGAGGACGGCGGC
GGCCGAGCCAGCTCGGCCATGGTGATCGGTGGCGGCGTGAGCAGCACGCTGGGTTCCGGGCTGCTCCTCG
AGGATTCGGCCATGCTGCTGGCTCCAGGAGGGCAGGACCTCGGGTCGGGGCCAGCGTCCGCCGCAGGCGC
TCTGAGTGGGGGCACGCCGACGCAGCTGCAGCCTCAGCAGCCACTGCCACAGCCGCAGCCGGGGGCGGCT
GGGGGCTCTGGGCAACCAAGGAAATGCTCCTCGCGGCGGAATGCCTGGGGGAACCTGTCCTATGCCGACC
TGATCACCCGCGCCATCGAGAGCTCCCCGGACAAACGGCTCACTTTGTCCCAGATCTACGAGTGGATGGT
GCGCTGTGTGCCCTACTTCAAGGATAAGGGCGACAGCAACAGCTCTGCGGGCTGGAAGAACTCCATCCGG
CACAACCTGTCCCTGCACAGCCGCTTCATGCGCGTTCAGAATGAAGGCACGGGCAAGAGCTCTTGGTGGA
TCATCAACCCCGATGGGGGAAAGAGCGGGAAGGCCCCCCGGCGGCGTGCGGTCTCCATGGACAACAGCAA
CAAGTACACCAAGAGCCGAGGCCGGGCAGCCAAGAAGAAGGCGGCCCTGCAGGCTGCCCCAGAGTCGGCA
GACGACAGTCCTTCCCAGCTCTCCAAGTGGCCTGGCAGCCCCACGTCCCGCAGCAGCGACGAGCTGGATG
CGTGGACCGACTTCCGCTCGCGCACCAATTCCAACGCCAGCACCGTGAGCGGCCGCCTGTCGCCCATCCT
GGCAAGCACGGAGCTGGATGACGTCCAGGATGATGATGGACCCCTGTCCCCCATGCTGTACAGCAGCTCT
GCCAGCCTGTCGCCCTCCGTGAGCAAGCCGTGTACTGTGGAGCTTCCGCGGCTGACGGACATGGCCGGCA
CCATGAATCTGAATGATGGGCTGGCCGAGAACCTCATGGACGACCTGCTGGATAACATCGCGCTCCCGCC
ATCGCAGCCATCGCCTCCTGGCGGGCTTATGCAGCGGGGCTCCAGCTTCCCATATACCGCCAAGAGCTCC
GGCCTGGGCTCCCCAACCGGCTCCTTCAACAGTACCGTGTTTGGACCTTCGTCTCTGAACTCCTTGCGTC
AGTCACCCATGCAGACTATCCAGGAGAACAGACCAGCCACCTTCTCTTCCGTGTCACACTACGGCAACCA
GACACTCCAAGACCTGCTTGCTTCAGACTCACTCAGCCACAGCGACGTCATGATGACCCAGTCGGACCCC
TTGATGTCTCAGGCTAGCACCGCCGTGTCCGCCCAGAATGCCCGCCGGAACGTGATGCTTCGCAACGATC
CAATGATGTCCTTTGCTGCCCAGCCTACCCAGGGGAGTTTGGTCAATCAGAACTTGCTCCACCACCAGCA
CCAAACCCAGGGCGCTCTTGGTGGCAGCCGTGCCTTGTCAAATTCTGTCAGCAACATGGGCTTGAGTGAC
TCCAGCAGCCTTGGCTCAGCCAAACACCAGCAGCAGTCTCCCGCCAGCCAGTCTATGCAAACCCTCTCGG
ACTCTCTCTCAGGCTCCTCACTGTATTCAGCTAGTGCAAACCTTCCCGTCATGGGCCACGATAAGTTCCC
CAGTGACTTGGACCTGGACATGTTCAATGGGAGCTTGGAATGTGACATGGAGTCCATCATCCGTAGTGAA
CTCATGGATGCTGACGGGTTGGATTTTAACTTTGACTCCCTCATCTCCACACAGAACGTTGTTGGTTTGA
ATGTGGGGAACTTCACTGGTGCTAAGCAGGCCTCATCTCAAAGCTGGGTACCAGGCTGA


ACGCGTACGCGGCCGCTCGAGCAGAAACTCATCTCAGAAGAGGATCTGGCAGCAAATGATATCCTGGATT
ACAAGGATGACGACGATAAGGTTTAA
Restriction Sites SgfI-MluI     
ACCN NM_019740
Insert Size 2019 bp
OTI Disclaimer Due to the inherent nature of this plasmid, standard methods to replicate additional amounts of DNA in E. coli are highly likely to result in mutations and/or rearrangements. Therefore, OriGene does not guarantee the capability to replicate this plasmid DNA. Additional amounts of DNA can be purchased from OriGene with batch-specific, full-sequence verification at a reduced cost. Please contact our customer care team at custsupport@origene.com or by calling 301.340.3188 option 3 for pricing and delivery.

The molecular sequence of this clone aligns with the gene accession number as a point of reference only. However, individual transcript sequences of the same gene can differ through naturally occurring variations (e.g. polymorphisms), each with its own valid existence. This clone is substantially in agreement with the reference, but a complete review of all prevailing variants is recommended prior to use. More info
Product Components The ORF clone is ion-exchange column purified and shipped in a 2D barcoded Matrix tube containing 10ug of transfection-ready, dried plasmid DNA (reconstitute with 100 ul of water).
Reconstitution 1. Centrifuge at 5,000xg for 5min.
2. Carefully open the tube and add 100ul of sterile water to dissolve the DNA.
3. Close the tube and incubate for 10 minutes at room temperature.
4. Briefly vortex the tube and then do a quick spin (less than 5000xg) to concentrate the liquid at the bottom.
5. Store the suspended plasmid at -20°C. The DNA is stable for at least one year from date of shipping when stored at -20°C.
Note Plasmids are not sterile.  For experiments where strict sterility is required, filtration with 0.22um filter is required.
Reference Data
RefSeq NM_019740.2, NP_062714.1
RefSeq Size 2889 bp
RefSeq ORF 2019 bp
Locus ID 56484
UniProt ID Q9WVH4
Gene Summary Transcriptional activator that recognizes and binds to the DNA sequence 5'-[AG]TAAA[TC]A-3' and regulates different processes, such as apoptosis and autophagy (PubMed:18054316, PubMed:18054315, PubMed:23805378). Acts as a positive regulator of autophagy in skeletal muscle: in starved cells, enters the nucleus following dephosphorylation and binds the promoters of autophagy genes, such as GABARAP1L, MAP1LC3B and ATG12, thereby activating their expression, resulting in proteolysis of skeletal muscle proteins (PubMed:18054316, PubMed:18054315, PubMed:25402684). Triggers apoptosis in the absence of survival factors, including neuronal cell death upon oxidative stress (By similarity). Participates in post-transcriptional regulation of MYC: following phosphorylation by MAPKAPK5, promotes induction of miR-34b and miR-34c expression, 2 post-transcriptional regulators of MYC that bind to the 3' UTR of MYC transcript and prevent its translation (By similarity). In response to metabolic stress, translocates into the mitochondria where it promotes mtDNA transcription (PubMed:23283301).[UniProtKB/Swiss-Prot Function]
*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.

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