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Zfp36l2 (NM_001001806) Mouse Untagged Clone
CAT＃: MC216614
Zfp36l2 (untagged) - Mouse zinc finger protein 36, C3H type-like 2 (Zfp36l2), (10ug)
CNY 3,656.00
CNY 6,270.00
Product images
Specifications
| Product Data | |
| Type | Mouse Untagged Clone |
| Tag | Tag Free |
| Synonyms | Brf2; ERF2; Tis11d |
| Vector | pCMV6-Entry |
| E. coli Selection | Kanamycin (25 ug/mL) |
| Mammalian Cell Selection | Neomycin |
| Sequence Data |
>MC216614 representing NM_001001806
Red=Cloning site Blue=ORF TTTTGTAATACGACTCACTATAGGGCGGCCGGGAATTCGTCGACTGGATCCGGTACCGAGGAGATCTGCC GCCGCGATCGCC ATGTCGACCACACTTCTGTCACCCTTCTACGATATCGACTTCTTGTGCAAGACGGAGAAATCCCTGGCAA ACCTCAATCTGAACAACATGCTGGACAAGAAGGCGGTAGGGACGCCCGTGGCTGCTGCCCCCAGCTCGAG CTTCACTCCGGGCTTCCTGCGACGCCACTCCGCCAGCAACCTCCACGCGCTTGCCCACCCTGTGCCCAGT CCGGGCAGCTGCTCGCCGAAGTTCCCGGGCGCCCCTAACGGCGGCGGCAGCAGCTGTGGCCCCGCAGGCG GAGGCGGTCTGGCCTCCTACGGCCAGCTCAAGGAGCCTTCGGGGGGCAGCGGCACGGCGCTGGTCACCAA GGAGAGCAAATTTCGGGACCGCTCGTTCAGCGAGAACGGGGAGCGCAGCCAGCACCTCCTGCACCTGCAG CAGCAGCAGAAGGGGGGCAGCGGCTCCCAGATCAACTCCACGCGCTACAAGACGGAGCTGTGCCGGCCCT TCGAGGAGAGCGGCACGTGCAAGTACGGCGAGAAGTGCCAGTTCGCGCACGGCTTCCACGAGCTGCGCAG CCTCACCCGGCACCCCAAGTACAAGACAGAGCTGTGCCGCACCTTCCACACCATCGGCTTCTGCCCCTAC GGCCCGCGCTGCCACTTCATCCACAACGCGGACGAGCGGCGGCCCGCGCCGTCGGGGGGCGGCGGCGCCT CCGGGGACCTGCGAGCGTTTGGCGCACGCGACGCGCTACACCTAGGCTTCGCCCGCGAGCCGCGGCCCAA GCTGCATCACAGCCTCAGTTTCTCCGGCTTCCCGTCGGGCCACCACCAGCCGCCGGGGGGCCTGGAGTCG CCGCTGCTGCTCGACAGCCCCACATCGCGCACGCCGCCGCCGCCCTCCTCCTCGGCCTCGTCCTGTTCCT CCTCGGCTTCTTCCTGCTCTTCCGCCTCGGCGGCCTCCACGCCCTCGGGCGCCCCGACGTGCTGCGCCAC GGCGGCGGCGGCCGCGCTGCTCTACGGCCCCGGGGGCGCGGAGGACCTGCTGAGCCCCGGAGCGCCGTGC GCCTCCTGCTCGTCCTCCGGCGCTAACAACGCCTTCGCTTTCGGCCCGGAGCTGAGCAGCCTCATCACGC CGCTCGCCATCCAGACCCACAACTTCGCCGCCGCGGCCGCCGCCGCCTACTACCGCAACCAGCAGCAGGG CCTGACCGGTCCCGCGCCACCCCCGGCACAGCCCCCCGCGGCCCCCGCGCCGCCCTCCCCGCCCTTCGGC TTCCAGCTGCCGCGCCGTCTGTCCGAGTCGCCCGTGTTCGACGCGCCCCCCAGCCCCCCGGACTCGCTCT CGGACCGCGACAGCTACCTGAGCGGCTCGCTGAGCTCCGGCAGCCTCAGCGGCTCCGAGTCCCCCAGCCT GGACCCTGGCCGTCGCCTACCCATCTTCAGCCGCCTCTCCATCTCCGACGACTGA ACGCGTACGCGGCCGCTCGAGCAGAAACTCATCTCAGAAGAGGATCTGGCAGCAAATGATATCCTGGATT ACAAGGATGACGACGATAAGGTTTAA |
| Restriction Sites | SgfI-MluI |
| ACCN | NM_001001806 |
| Insert Size | 1455 bp |
| OTI Disclaimer | Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP). |
| Product Components | The ORF clone is ion-exchange column purified and shipped in a 2D barcoded Matrix tube containing 10ug of transfection-ready, dried plasmid DNA (reconstitute with 100 ul of water). |
| Reconstitution | 1. Centrifuge at 5,000xg for 5min. 2. Carefully open the tube and add 100ul of sterile water to dissolve the DNA. 3. Close the tube and incubate for 10 minutes at room temperature. 4. Briefly vortex the tube and then do a quick spin (less than 5000xg) to concentrate the liquid at the bottom. 5. Store the suspended plasmid at -20°C. The DNA is stable for at least one year from date of shipping when stored at -20°C. |
| Note | Plasmids are not sterile. For experiments where strict sterility is required, filtration with 0.22um filter is required. |
| Reference Data | |
| RefSeq | BC139416, AAI39417 |
| RefSeq Size | 2129 bp |
| RefSeq ORF | 1455 bp |
| Locus ID | 12193 |
| UniProt ID | P23949 |
| Gene Summary | Zinc-finger RNA-binding protein that destabilizes several cytoplasmic AU-rich element (ARE)-containing mRNA transcripts by promoting their poly(A) tail removal or deadenylation, and hence provide a mechanism for attenuating protein synthesis (PubMed:22701344, PubMed:22367205, PubMed:25505318, PubMed:24830504, PubMed:27102483). Acts as a 3'-untranslated region (UTR) ARE mRNA-binding adapter protein to communicate signaling events to the mRNA decay machinery (By similarity). Functions by recruiting the CCR4-NOT deadenylase complex and probably other components of the cytoplasmic RNA decay machinery to the bound ARE-containing mRNAs, and hence promotes ARE-mediated mRNA deadenylation and decay processes (By similarity). Binds to 3' UTR ARE of numerous mRNAs (PubMed:22701344, PubMed:22367205, PubMed:25505318, PubMed:24830504). Promotes ARE-containing mRNA decay of the low-density lipoprotein (LDL) receptor (LDLR) mRNA in response to phorbol 12-myristate 13-acetate (PMA) treatment in a p38 MAPK-dependent manner (By similarity). Positively regulates early adipogenesis by promoting ARE-mediated mRNA decay of immediate early genes (IEGs) (PubMed:22701344). Plays a role in mature peripheral neuron integrity by promoting ARE-containing mRNA decay of the transcriptional repressor REST mRNA (PubMed:25505318). Plays a role in ovulation and oocyte meiotic maturation by promoting ARE-mediated mRNA decay of the luteinizing hormone receptor LHCGR mRNA (PubMed:24830504). Acts as a negative regulator of erythroid cell differentiation: promotes glucocorticoid-induced self-renewal of erythroid cells by binding mRNAs that are induced or highly expressed during terminal erythroid differentiation and promotes their degradation, preventing erythroid cell differentiation (PubMed:19633199, PubMed:23748442). In association with ZFP36L1 maintains quiescence on developing B lymphocytes by promoting ARE-mediated decay of several mRNAs encoding cell cycle regulators that help B cells progress through the cell cycle, and hence ensuring accurate variable-diversity-joining (VDJ) recombination process and functional immune cell formation (PubMed:27102483). Together with ZFP36L1 is also necessary for thymocyte development and prevention of T-cell acute lymphoblastic leukemia (T-ALL) transformation by promoting ARE-mediated mRNA decay of the oncogenic transcription factor NOTCH1 mRNA (PubMed:20622884).[UniProtKB/Swiss-Prot Function] |
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Resources
Other Versions
| SKU | Description | Size | Price |
|---|---|---|---|
| MG225999 | Zfp36l2 (tGFP-tagged) - Mouse zinc finger protein 36 C3H type-like 2 (Zfp36l2), (10ug) |
CNY 4,750.00 |
|
| MR225999 | Zfp36l2 (Myc-DDK-tagged) - Mouse zinc finger protein 36, C3H type-like 2 (Zfp36l2) |
CNY 3,656.00 |
|
| MR225999L3 | Lenti ORF clone of Zfp36l2 (Myc-DDK-tagged) - Mouse zinc finger protein 36, C3H type-like 2 (Zfp36l2) |
CNY 6,180.00 |
|
| MR225999L4 | Lenti ORF clone of Zfp36l2 (mGFP-tagged) - Mouse zinc finger protein 36, C3H type-like 2 (Zfp36l2) |
CNY 6,056.00 |
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