Aurkc (BC064780) Mouse Untagged Clone

Specifications

Product Data
Type	Mouse Untagged Clone
Tag	Tag Free
Synonyms	AIK3, AIE1
Vector	PCMV6-Kan/Neo
E. coli Selection	Kanamycin (25 ug/mL)
Mammalian Cell Selection	Neomycin
Sequence Data	Fully Sequenced ORF (showhide) >BC064780 GGCAGTGCTAGTGGATTACCAGTGTGTGTGTCCCGTGTGTCCCTGGGTGGGTGAGACATTCCGGGCGGTT GGGGAGGCTGGAGTCAGAGCGTTACCCGCCTACCCTTTTCCAGGATCTAAGCAACTAGCAGGACTTCAAC TTGCCCTCACCTCTTTAGAGTTCAGGGAAGAGTCACCTCCTTCGGGCTGGGCTTCACACACAAGTAAGAG GTAGGAAAACCCGGACCGACTCCAAAGTGGTGGCACGTATGAGAAAGATCCCTGCAAGCAGGAGGATGAG GCAGCAGGATGGGGACAGTTAGAGGTCACTGGGATCCGCAGCCAGGGGTTCGCTACTGGCCAGATGGAGC CCAGCACCTCAACCAGGAAGCATTTCACCATCAATGACTTTGAAATCGGGCGTCCTCTGGGCAGGGGGAA ATTTGGGCGTGTGTACTTGGCTCGGCTCAAGGAAAATCATTTCATCGTGGCCCTGAAGGTCCTCTTCAAG TCTGAGATAGAGAAGGAGGGATTGGAGCACCAACTTCGCAGGGAAGTGGAGATCCAGGCACACCTACAAC ACCGGAACATCCTTCGCCTGTACAACTACTTCTATGATGACACTCGGATATACTTAATTCTGGAGTATGC TCCAGGAGGAGAGCTCTATAAGGAGCTTCAGAGACATCAGAAGTTGGACCAGCAGCGTACAGCCACGATA ATACAGGAGTTGTCAGATGCCCTGACCTACTGCCATGAGAAGAAGGTGATTCACAGGGACATCAAGCCAG AGAATCTCCTGCTGGGCCTCAATGGTGAGGTGAAGATCTCAGACTTTGGGTGGTCTGTGCATACCCCCTC TCTCAGGAGAAAGACAATGTGTGGGACTCTGGACTACTTGCCCCCGGAAATGATAGCGCAGAAACCGTAC AATGAGATGGTTGATCTGTGGTGCATTGGGGTGCTCTGCTATGAGCTGCTGGTGGGGAAGCCACCCTTTG AGAGCAGCACCTCCAGTGAGACATACAGACGCATCCGCCAGGTGGATTTTAAGTTTCCTTCATCAGTACC TGCAGGAGCCCAGGACTTGATCTCCAAGCTTCTTAGGTACCATCCTTCAGAGCGGCTGAGCCTGGCCCAG GTCCTGAAGCACCCCTGGGTCAGGGAACACTCTCGAAGGGTGCTTCCTTGCTAGTTCAGGGGTCGTCCTG AGCCCTGTCCATCTCTATCCCTATGTATTTCTTCAGGAAGGTCTCCAGGCTCTGTTTGTTAGTGCATGTG GTTCGCTTGTTTTCTCTTTTATGAAGTGATGTTAATTAAAACTGATTATTTTAGCATCAAAAAAAAAAAA AAAAAAAAAAAAAAAAAAAAAAAAAAAA
Restriction Sites	EcoRI-NotI
ACCN	BC064780
Insert Size	831 bp
OTI Disclaimer	Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP).
Product Components	The ORF clone is ion-exchange column purified and shipped in a 2D barcoded Matrix tube containing 10ug of transfection-ready, dried plasmid DNA (reconstitute with 100 ul of water).
Reconstitution	1. Centrifuge at 5,000xg for 5min. 2. Carefully open the tube and add 100ul of sterile water to dissolve the DNA. 3. Close the tube and incubate for 10 minutes at room temperature. 4. Briefly vortex the tube and then do a quick spin (less than 5000xg) to concentrate the liquid at the bottom. 5. Store the suspended plasmid at -20°C. The DNA is stable for at least one year from date of shipping when stored at -20°C.
Reference Data
RefSeq	BC064780, AAH64780
RefSeq Size	1358 bp
RefSeq ORF	831 bp
Locus ID	20871
Gene Summary	Serine/threonine-protein kinase component of the chromosomal passenger complex (CPC), a complex that acts as a key regulator of mitosis. The CPC complex has essential functions at the centromere in ensuring correct chromosome alignment and segregation and is required for chromatin-induced microtubule stabilization and spindle assembly. Plays also a role in meiosis and more particularly in spermatogenesis. Has redundant cellular functions with AURKB and can rescue an AURKB knockdown. Like AURKB, AURKC phosphorylates histone H3 at 'Ser-10' and 'Ser-28'. AURKC phosphorylates the CPC complex subunits BIRC5/survivin and INCENP leading to increased AURKC activity. Phosphorylates TACC1, another protein involved in cell division, at 'Ser-228'.[UniProtKB/Swiss-Prot Function]

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