Psen2 (BC010403) Mouse Untagged Clone

Specifications

Product Data
Type	Mouse Untagged Clone
Tag	Tag Free
Synonyms	PS2, PS-2, ALG-3
Vector	PCMV6-Kan/Neo
E. coli Selection	Kanamycin (25 ug/mL)
Mammalian Cell Selection	Neomycin
Sequence Data	Fully Sequenced ORF (showhide) >BC010403 CCACGCGTCCGCCCACGCGTCCGGGCGGAGCAGACCATGCTCGCATTCATGGCCTCTGACAGCGAGGAAG AGGTGTGTGATGAGCGGACGTCCTTGATGTCAGCCGAGAGCCCCACATCTCGCTCCTGCCAGGAAGGCAG GCCAGGCCCGGAGGATGGAGAGAGCACTGCCCAGTGGAGGACTCAGGAGAGCGAAGAAGACTGTGAAGAG GACCCGGACCGCTACGCATGCAGTGGGGCTCCTGGGCGACCGTCGGGCCTGGAGGAAGAGCTGACCCTCA AGTATGGGGCGAAGCATGTGATCATGCTATTCGTGCCTGTCACGCTGTGTATGATCGTGGTGGTGGCCAC TATCAAGTCTGTGCGTTTCTACACTGAGAAGAACGGGCAGCTCATCTACACGCCCTTCACGGAGGACACG CCCTCGGTGGGCCAGCGGCTCCTCAACTCCGTGCTTAACACCCTCATCATGATCAGCGTCATCGTAGTCA TGACCATCTTCCTCGTGGTACTCTACAAGTATCGATGCTACAAGTTCATCCATGGCTGGCTGATCATGTC CTCCCTGATGCTCCTCTTCTTGTTCACCTACATCTACCTCGGGGAAGTGCTCAAGACCTACAATGTGGCC ATGGACTATCCCACACTCTTCCTGGCTGTCTGGAACTTCGGGGCAGTGGGCATGGTGTGCATCCACTGGA AGGGGCCTCTGGTGCTGCAGCAGGCTTACCTTATTGTGATCAGCGCACTCATGGCCCTGGTGTTCATCAA GTACCTGCCGGAGTGGTCTGCCTGGGTCATCTTGGGTGCCATCTCTGTGTACGATCTCGTGGCCGTGCTG TGCCCCAAAGGGCCACTGAGGATGCTGGTGGAAACTGCCCAGGAGAGAAATGAGCCCATATTTCCTGCCC TGATATACTCATCTGCCATGGTGTGGACGGTGGGCATGGCAAAGCTGGACCCCTCCTCTCAAGGAGCGCT GCAGCTCCCCTATGACCCAGAGATGGAAGAAGACTCCTACGACAGTTTTGGAGAACCCTCATACCCTGAA GCCTTCGAAGCTCCCCTGCCTGGCTACCCAGGGGAGGAGCTGGAGGAGGAGGAGGAAAGGGGCGTGAAGC TCGGCCTGGGAGACTTCATCTTCTACAGCGTCCTGGTGGGCAAGGCTGCAGCCACTGGCAACGGAGACTG GAACACTACGCTGGCCTGTTTTATCGCCATCCTCATTGGCTTGTGTCTCACCCTCCTGCTGCTTGCTGTG TTCAAGAAGGCTCTGCCCGCCCTCCCCATCTCCATCACCTTTGGACTCATCTTCTACTTCTCCACAGACA ACCTGGTGCGCCCTTTCATGGACACTCTGGCCTCCCACCAGCTCTACATCTGACAGGAGCCAGGCGGAGG CTCCGAGAGCTATGGGGGCGTCACTGGATGCAGGTGTATAGTTTTACACTCTAGTGCCATATATTTTTTA AAGAAATTTTCTTTCCTTACAAAAGAAGAAGAAGAAAAAAAAAAAAAAAA
Restriction Sites	EcoRI-NotI
ACCN	BC010403
Insert Size	1347 bp
OTI Disclaimer	Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP).
Product Components	The ORF clone is ion-exchange column purified and shipped in a 2D barcoded Matrix tube containing 10ug of transfection-ready, dried plasmid DNA (reconstitute with 100 ul of water).
Reconstitution	1. Centrifuge at 5,000xg for 5min. 2. Carefully open the tube and add 100ul of sterile water to dissolve the DNA. 3. Close the tube and incubate for 10 minutes at room temperature. 4. Briefly vortex the tube and then do a quick spin (less than 5000xg) to concentrate the liquid at the bottom. 5. Store the suspended plasmid at -20°C. The DNA is stable for at least one year from date of shipping when stored at -20°C.
Reference Data
RefSeq	BC010403, AAH10403
RefSeq Size	1520 bp
RefSeq ORF	1347 bp
Locus ID	19165
Gene Summary	This gene encodes a member of the presenilin family. Presenilins are catalytic components of the multi-subunit gamma-secretase complex, which mediates critical cellular processes through cleavage of type I transmembrane proteins including Notch receptors and the amyloid precursor protein. The encoded protein contains eight transmembrane domains and is localized to the endoplasmic reticulum, where it may play a role in calcium homeostasis. Following assembly of the gamma-secretase complex, the encoded protein is cleaved into N- and C-terminal fragments and the activated complex is released from the endoplasmic reticulum. Inactivation of this gene results in impaired synaptic function in a mouse model for Alzheimer's disease. Alternatively spliced transcript variants have been observed for this gene. [provided by RefSeq, Apr 2011]

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