Lrp5 (NM_008513) Mouse Untagged Clone

CAT#: MC203730

Lrp5 (untagged) - Mouse low density lipoprotein receptor-related protein 5 (Lrp5), (10ug)



  "NM_008513" in other vectors (4)

CNY 11,048.00


货期*
现货

规格
    • 10 ug

Product images

经常一起买 (3)
TurboFectin Transfection Reagent (1 mL in 1 vial)
    • 1 ml in 1 vial

CNY 4,090.00


DH5α Chemically Competent Cells (≥10^8 cfu/μg of pUC19 DNA)
    • 5 x 200 ul

CNY 1,280.00


Forward sequencing primer VP1.5, Reverse sequencing primer XL39, 100pmoles each
    • 100 pmol

CNY 480.00

Specifications

Product Data
Type Mouse Untagged Clone
Tag Tag Free
Synonyms BMND1; HBM; LR3; LRP7; mKIAA4142; OPPG
Vector pCMV6-Entry
E. coli Selection Kanamycin (25 ug/mL)
Mammalian Cell Selection Neomycin
Sequence Data
>MC203730 representing NM_008513.
Blue=ORF Red=Cloning site Green=Tag(s)

CTATAGGGCGGCCGGGAATTCGTCGACTGGATCCGGTACCGAGGAGATCTGCCGCCGCGATCGCCGGCG
CGCCAGATCTCAAGCTTAACTAGCTAGCGGACCGAC
ATGGAAACGGCGCCGACCCGGGCCCCTCCGCCGCCGCCGCCGCCGCTGCTGCTGCTGGTGCTGTACTGC
AGCTTGGTCCCCGCCGCGGCCTCACCGCTCCTGTTGTTTGCCAACCGCCGGGATGTGCGGCTAGTGGAT
GCCGGCGGAGTGAAGCTGGAGTCCACCATTGTGGCCAGTGGCCTGGAGGATGCAGCTGCTGTAGACTTC
CAGTTCTCCAAGGGTGCTGTGTACTGGACAGATGTGAGCGAGGAGGCCATCAAACAGACCTACCTGAAC
CAGACTGGAGCTGCTGCACAGAACATTGTCATCTCGGGCCTCGTGTCACCTGATGGCCTGGCCTGTGAC
TGGGTTGGCAAGAAGCTGTACTGGACGGACTCCGAGACCAACCGCATTGAGGTTGCCAACCTCAATGGG
ACGTCCCGTAAGGTTCTCTTCTGGCAGGACCTGGACCAGCCAAGGGCCATTGCCCTGGATCCTGCACAT
GGGTACATGTACTGGACTGACTGGGGGGAAGCACCCCGGATCGAGCGGGCAGGGATGGATGGCAGTACC
CGGAAGATCATTGTAGACTCCGACATTTACTGGCCCAATGGGCTGACCATCGACCTGGAGGAACAGAAG
CTGTACTGGGCCGATGCCAAGCTCAGCTTCATCCACCGTGCCAACCTGGACGGCTCCTTCCGGCAGAAG
GTGGTGGAGGGCAGCCTCACTCACCCTTTTGCCCTGACACTCTCTGGGGACACACTCTACTGGACAGAC
TGGCAGACCCGCTCCATCCACGCCTGCAACAAGTGGACAGGGGAGCAGAGGAAGGAGATCCTTAGTGCT
CTGTACTCACCCATGGACATCCAAGTGCTGAGCCAGGAGCGGCAGCCTCCCTTCCACACACCATGCGAG
GAGGACAACGGTGGCTGTTCCCACCTGTGCCTGCTGTCCCCGAGGGAGCCTTTCTACTCCTGTGCCTGC
CCCACTGGTGTGCAGTTGCAGGACAATGGCAAGACGTGCAAGACAGGGGCTGAGGAAGTGCTGCTGCTG
GCTCGGAGGACAGACCTGAGGAGGATCTCTCTGGACACCCCTGACTTCACAGACATAGTGCTGCAGGTG
GGCGACATCCGGCATGCCATTGCCATTGACTACGATCCCCTGGAGGGCTACGTGTACTGGACCGACGAT
GAGGTGCGGGCTATCCGCAGGGCGTACCTAGATGGCTCAGGTGCGCAGACACTTGTGAACACTGAGATC
AATGACCCCGATGGCATTGCTGTGGACTGGGTCGCCCGGAACCTCTACTGGACAGATACAGGCACTGAC
AGAATTGAGGTGACTCGCCTCAACGGCACCTCCCGAAAGATCCTGGTATCTGAGGACCTGGACGAACCG
CGAGCCATTGTGTTGCACCCTGTGATGGGCCTCATGTACTGGACAGACTGGGGGGAGAACCCCAAAATC
GAATGCGCCAACCTAGATGGGAGAGATCGGCATGTCCTGGTGAACACCTCCCTTGGGTGGCCCAACGGA
CTGGCCCTGGACCTGCAGGAGGGCAAGCTGTACTGGGGGGATGCCAAAACTGATAAAATCGAGGTGATC
AACATAGATGGGACAAAGCGGAAGACCCTGCTTGAGGACAAGCTCCCACATATTTTTGGGTTCACACTG
CTGGGGGACTTCATCTACTGGACCGACTGGCAGAGACGCAGTATTGAAAGGGTCCACAAGGTCAAGGCC
AGCCGGGATGTCATCATTGATCAACTCCCCGACCTGATGGGACTCAAAGCTGTGAATGTGGCCAAGGTT
GTCGGAACCAACCCATGTGCGGATGGAAATGGAGGGTGCAGCCATCTGTGCTTCTTCACCCCACGTGCC
ACCAAGTGTGGCTGCCCCATTGGCCTGGAGCTGTTGAGTGACATGAAGACCTGCATAATCCCCGAGGCC
TTCCTGGTATTCACCAGCAGAGCCACCATCCACAGGATCTCCCTGGAGACTAACAACAACGATGTGGCT
ATCCCACTCACGGGTGTCAAAGAGGCCTCTGCACTGGACTTTGATGTGTCCAACAATCACATCTACTGG
ACTGATGTCAGCCTCAAGACGATCAGCCGAGCCTTCATGAATGGGAGCTCAGTGGAGCACGTGATTGAG
TTTGGCCTCGACTACCCTGAAGGAATGGCTGTGGACTGGATGGGCAAGAACCTCTATTGGGCGGACACA
GGGACCAACAGGATTGAGGTGGCCCGGCTGGATGGGCAGTTCCGGCAGGTGCTTGTGTGGAGAGACCTT
GACAACCCCAGGTCTCTGGCTCTGGATCCTACTAAAGGCTACATCTACTGGACTGAGTGGGGTGGCAAG
CCAAGGATTGTGCGGGCCTTCATGGATGGGACCAATTGTATGACACTGGTAGACAAGGTGGGCCGGGCC
AACGACCTCACCATTGATTATGCCGACCAGCGACTGTACTGGACTGACCTGGACACCAACATGATTGAG
TCTTCCAACATGCTGGGTCAGGAGCGCATGGTGATAGCTGACGATCTGCCCTACCCGTTTGGCCTGACT
CAATATAGCGATTACATCTACTGGACTGACTGGAACCTGCATAGCATTGAACGGGCGGACAAGACCAGT
GGGCGGAACCGCACCCTCATCCAGGGTCACCTGGACTTCGTCATGGACATCCTGGTGTTCCACTCCTCC
CGTCAGGATGGCCTCAACGACTGCGTGCACAGCAATGGCCAGTGTGGGCAGCTGTGCCTCGCCATCCCC
GGAGGCCACCGCTGTGGCTGTGCTTCACACTACACGCTGGACCCCAGCAGCCGCAACTGCAGCCCGCCC
TCCACCTTCTTGCTGTTCAGCCAGAAATTTGCCATCAGCCGGATGATCCCCGATGACCAGCTCAGCCCG
GACCTTGTCCTACCCCTTCATGGGCTGAGGAACGTCAAAGCCATCAACTATGACCCGCTGGACAAGTTC
ATCTACTGGGTGGACGGGCGCCAGAACATCAAGAGGGCCAAGGACGACGGTACCCAGCCCTCCATGCTG
ACCTCTCCCAGCCAAAGCCTGAGCCCAGACAGACAGCCACACGACCTCAGCATTGACATCTACAGCCGG
ACACTGTTCTGGACCTGTGAGGCCACCAACACTATCAATGTCCACCGGCTGGATGGGGATGCCATGGGA
GTGGTGCTTCGAGGGGACCGTGACAAGCCAAGGGCCATTGCTGTCAATGCTGAGCGAGGGTACATGTAC
TTTACCAACATGCAGGACCATGCTGCCAAGATCGAGCGAGCCTCCCTGGATGGCACAGAGCGGGAGGTC
CTCTTCACCACAGGCCTCATCCGTCCCGTGGCCCTTGTGGTGGACAATGCTCTGGGCAAGCTCTTCTGG
GTGGATGCCGACCTAAAGCGAATCGAAAGCTGTGACCTCTCTGGGGCCAACCGCCTGACCCTGGAAGAT
GCCAACATCGTACAGCCAGTAGGTCTGACAGTGCTGGGCAGGCACCTCTACTGGATCGACCGCCAGCAG
CAGATGATCGAGCGCGTGGAGAAGACCACTGGGGACAAGCGGACTAGGGTTCAGGGCCGTGTCACCCAC
CTGACAGGCATCCATGCCGTGGAGGAAGTCAGCCTGGAGGAGTTCTCAGCCCATCCTTGTGCCCGAGAC
AATGGCGGCTGCTCCCACATCTGTATCGCCAAGGGTGATGGAACACCGCGCTGCTCGTGCCCTGTCCAC
CTGGTGCTCCTGCAGAACCTGCTGACTTGTGGTGAGCCTCCTACCTGCTCCCCTGATCAGTTTGCATGT
ACCACTGGTGAGATCGACTGCATCCCCGGAGCCTGGCGCTGTGACGGCTTCCCTGAGTGTGCTGACCAG
AGTGATGAAGAAGGCTGCCCAGTGTGCTCCGCCTCTCAGTTCCCCTGCGCTCGAGGCCAGTGTGTGGAC
CTGCGGTTACGCTGCGACGGTGAGGCCGACTGCCAGGATCGCTCTGATGAAGCTAACTGCGATGCTGTC
TGTCTGCCCAATCAGTTCCGGTGCACCAGCGGCCAGTGTGTCCTCATCAAGCAACAGTGTGACTCCTTC
CCCGACTGTGCTGATGGGTCTGATGAGCTCATGTGTGAAATCAACAAGCCACCCTCTGATGACATCCCA
GCCCACAGCAGTGCCATTGGGCCCGTCATTGGTATCATCCTCTCCCTCTTCGTCATGGGCGGGGTCTAC
TTTGTCTGCCAGCGTGTGATGTGCCAGCGCTACACAGGGGCCAGTGGGCCCTTTCCCCACGAGTATGTT
GGTGGAGCCCCTCATGTGCCTCTCAACTTCATAGCCCCAGGTGGCTCACAGCACGGTCCCTTCCCAGGC
ATCCCGTGCAGCAAGTCCGTGATGAGCTCCATGAGCCTGGTGGGGGGGCGCGGCAGTGTGCCCCTCTAT
GACCGGAATCACGTCACTGGGGCCTCATCCAGCAGCTCGTCCAGCACAAAGGCCACACTATATCCGCCG
ATCCTGAACCCACCCCCGTCCCCGGCCACAGACCCCTCTCTCTACAACGTGGACGTGTTTTATTCTTCA
GGCATCCCGGCCACCGCTAGACCATACAGGCCCTACGTCATTCGAGGTATGGCACCCCCAACAACACCG
TGCAGCACAGATGTGTGTGACAGTGACTACAGCACCAGTCGCTGGAAGAGCAGCAAATACTACCTGGAC
TTGAATTCGGACTCAGACCCCTACCCCCCCCCGCCCACCCCCCACAGCCAGTACCTATCTGCAGAGGAC
AGCTGCCCACCCTCACCAGGCACTGAGAGGAGTTACTGCCACCTCTTCCCGCCCCCACCGTCCCCCTGC
ACGGACTCGTCCTGA

ACGCGGCCGCTCGAGCAGAAACTCATCTCAGAAGAGGATCTGGCAGCAAATGATATCCTGGATTACAAG
GATGACGACGATAAG
GTTTAAACGGCCGGCCGCGGT
Chromatograms CHROMATOGRAMS
Sequencher program is needed, download here.
Restriction Sites RsrII-NotI     
ACCN NM_008513
Insert Size 4845 bp
OTI Disclaimer Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP).
Product Components The ORF clone is ion-exchange column purified and shipped in a 2D barcoded Matrix tube containing 10ug of transfection-ready, dried plasmid DNA (reconstitute with 100 ul of water).
Reconstitution 1. Centrifuge at 5,000xg for 5min.
2. Carefully open the tube and add 100ul of sterile water to dissolve the DNA.
3. Close the tube and incubate for 10 minutes at room temperature.
4. Briefly vortex the tube and then do a quick spin (less than 5000xg) to concentrate the liquid at the bottom.
5. Store the suspended plasmid at -20°C. The DNA is stable for at least one year from date of shipping when stored at -20°C.
Note Plasmids are not sterile.  For experiments where strict sterility is required, filtration with 0.22um filter is required.
Reference Data
RefSeq BC011374
RefSeq Size 5172 bp
RefSeq ORF 4845 bp
Locus ID 16973
UniProt ID Q91VN0
MW 178.9 kDa
Gene Summary Acts as a coreceptor with members of the frizzled family of seven-transmembrane spanning receptors to transduce signal by Wnt proteins. Activates the canonical Wnt signaling pathway that controls cell fate determination and self-renewal during embryonic development and adult tissue regeneration (PubMed:11956231). In particular, may play an important role in the development of the posterior patterning of the epiblast during gastrulation (PubMed:15142971). During bone development, regulates osteoblast proliferation and differentiation thus determining bone mass (PubMed:11956231). Mechanistically, the formation of the signaling complex between Wnt ligand, frizzled receptor and LRP5 coreceptor promotes the recruitment of AXIN1 to LRP5, stabilizing beta-catenin/CTNNB1 and activating TCF/LEF-mediated transcriptional programs (By similarity). Acts as a coreceptor for non-Wnt proteins, such as norrin/NDP. Binding of norrin/NDP to frizzled 4/FZD4-LRP5 receptor complex triggers beta-catenin/CTNNB1-dependent signaling known to be required for retinal vascular development (By similarity). Plays a role in controlling postnatal vascular regression in retina via macrophage-induced endothelial cell apoptosis (PubMed:11956231).[UniProtKB/Swiss-Prot Function]
*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.

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