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Pdk2 (NM_133667) Mouse Untagged Clone
CAT＃: MC203148
Pdk2 (untagged) - Mouse pyruvate dehydrogenase kinase, isoenzyme 2 (Pdk2), nuclear gene encoding mitochondrial protein, (10ug)
CNY 2,000.00
| Cited in 1 publication. |
Product images
Specifications
| Product Data | |
| Type | Mouse Untagged Clone |
| Tag | Tag Free |
| Vector | PCMV6-Kan/Neo |
| E. coli Selection | Kanamycin (25 ug/mL) |
| Mammalian Cell Selection | Neomycin |
| Sequence Data |
>BC021764
GGCCGGTGCCAGCGCCTCCAGCCCCGGGACAGCAGCGAGATCCAAGCCCGAGCCGCAGGCGCCGTCGCCA TGCGCTGGGTCCGGGCGCTGTTGAAGAATGCGTCCCTGGCAGGGGCACCCAAGTACATCGAGCACTTCAG CAAGTTCTCCCCGTCCCCGTTGTCCATGAAGCAGTTTCTAGACTTCGGATCCAGCAATGCCTGCGAGAAG ACGTCATTCACTTTCCTCCGGCAGGAGCTGCCCGTTCGCCTGGCCAACATCATGAAAGAGATCAACCTGC TTCCTGACCGAGTGCTGGGCACCCCATCGGTGCAGCTGGTGCAGAGCTGGTATGTCCAGAGTCTGCTGGA CATCATGGAATTCCTGGACAAAGACCCCGAGGACCACCGGACTCTAAGCCAGTTCACAGATGCCCTGGTC ACCATCCGGAACCGGCACAATGACGTGGTGCCCACCATGGCACAGGGAGTGCTGGAGTACAAGGACACCT ATGGAGATGACCCCGTCTCCAACCAGAACATCCAGTACTTCCTGGACCGCTTCTACCTCAGCCGCATCTC CATCCGAATGCTAATCAATCAACACACCCTCATCTTTGATGGCAGCACCAACCCAGCCCACCCCAAACAC ATTGGCAGCATCGATCCCAACTGCAGCGTGTCTGATGTGGTGAAAGACGCCTATGACATGGCTAAGCTCC TGTGTGACAAGTATTACATGGCTTCCCCTGACCTGGAGATCCAGGAAGTCAATGCCACCAACGCCAACCA GCCCATTCACATGGTCTATGTCCCTTCCCACCTGTACCACATGCTCTTTGAACTCTTTAAGAATGCCATG CGGGCCACTGTGGAAAGCCACGAGTCCAGCCTCACACTCCCCCCCATCAAGATTATGGTGGCCCTCGGTG AAGAAGATCTGTCCATCAAAATGAGTGACCGAGGCGGGGGTGTCCCCTTGAGGAAGATCGAGAGGCTCTT CAGCTACATGTACTCCACAGCTCCCACACCCCAGCCTGGCACTGGGGGTACCCCGCTGGCTGGCTTTGGG TACGGACTCCCCATTTCCCGCCTCTACGCCAAGTACTTCCAGGGGGACTTGCAGCTTTTCTCTATGGAGG GCTTTGGGACAGATGCTGTCATCTATCTGAAGGCCCTGTCCACGGACTCAGTGGAGCGCCTGCCTGTCTA CAACAAGTCTGCCTGGCGCCACTACCAGACCATCCAGGAGGCCGGCGACTGGTGTGTGCCCAGCACAGAG CCCAAGAACACATCGACGTATCGGGTCAGCTAGGGGCCTTCCCTCCCTGGCACCTGTAGGATGCTGCCAC CTCTGAATCCAGCCACCACAGGGACCTTCCCTATCTATCCCCTAGGGTACAAGGGGTGAAACTGGGTCTC CCTGATGGCCAGATCTGTCTTTGTAGAAATCTCAGTGGCCCAACTGTGGTGGTCCCTAAGTGCCAATATG TCTCTGTGGAGAAACCCTAGGGGGTTTCCCTGGAACCCGGTTTCCATAGTGATGCTTGAGGGTTGGGGAT GGCTCTCCCTGATGGGGTGGCCCAGAGACACTTCTCCCAAGATCAGAACTGTCTGTTTTCTACTAGAAGC CCTGGTTCCCCCTCACTGCCTGCATAGTCCTGGCCTTCCAAGTGGCTGCTCCGCTTGCCTTATGCCCACA CACTGTACAGGCACATTTGGGCTGGGTTCTTTGTCAATGTTAAGAAGGATGGAGTGCCCTCAAGTCTGGA GAGGGACTGGGGGAAGATAGGGTCCACCCTTGACTCTGATCCTGCAGCCTCTATCTCTACTCTGGATGGT ATGAAGTTGCAATTGGGAACTTGAGAGTAGGTAGCGATTCTCACCCGGGGCCCACCGAGAGGGCAGGCCT AGGAGTAAGCTGCCCCCAAGGTGATCTTAGCAATGTTTCTGTTTAGCTGCTTCCTAAAGCCTTGCCCACC CAGCATGTCCTCACGTGCACACCTCCCCTGCCCAGTCTACACCCACCCTATGCTGCCTGAGCTTCAGACC CCACCCCACCCCTATGCCCACTATGTGTGCACAAGTGACTCACCCCTAGGACAGCCCTATGTACATAGCC AGTTTTGTAATCTCAGAAGCCCTGCCCTTCCCCTCCACACACAGGGGTTAAAGCCGTGTGCCCTCCCAGT GGCTGGGATGGTGACAGTGACATCCACAGTAAACAGATGAAATGTGAAAAAAAAAAAAAAA |
| Restriction Sites | RsrII-NotI |
| ACCN | NM_133667 |
| Insert Size | 1224 bp |
| OTI Disclaimer | Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP). |
| Product Components | The ORF clone is ion-exchange column purified and shipped in a 2D barcoded Matrix tube containing 10ug of transfection-ready, dried plasmid DNA (reconstitute with 100 ul of water). |
| Reconstitution | 1. Centrifuge at 5,000xg for 5min. 2. Carefully open the tube and add 100ul of sterile water to dissolve the DNA. 3. Close the tube and incubate for 10 minutes at room temperature. 4. Briefly vortex the tube and then do a quick spin (less than 5000xg) to concentrate the liquid at the bottom. 5. Store the suspended plasmid at -20°C. The DNA is stable for at least one year from date of shipping when stored at -20°C. |
| Reference Data | |
| RefSeq | BC021764, AAH21764 |
| RefSeq Size | 2231 bp |
| RefSeq ORF | 1224 bp |
| Locus ID | 18604 |
| UniProt ID | Q9JK42 |
| Gene Summary | Kinase that plays a key role in the regulation of glucose and fatty acid metabolism and homeostasis via phosphorylation of the pyruvate dehydrogenase subunits PDHA1 and PDHA2. This inhibits pyruvate dehydrogenase activity, and thereby regulates metabolite flux through the tricarboxylic acid cycle, down-regulates aerobic respiration and inhibits the formation of acetyl-coenzyme A from pyruvate. Inhibition of pyruvate dehydrogenase decreases glucose utilization and increases fat metabolism. Mediates cellular responses to insulin. Plays an important role in maintaining normal blood glucose levels and in metabolic adaptation to nutrient availability. Via its regulation of pyruvate dehydrogenase activity, plays an important role in maintaining normal blood pH and in preventing the accumulation of ketone bodies under starvation. Plays a role in the regulation of cell proliferation and in resistance to apoptosis under oxidative stress. Plays a role in p53/TP53-mediated apoptosis.[UniProtKB/Swiss-Prot Function] |
Citations (1)
| The use of this cDNA Clones has been cited in the following citations: |
|---|
|
Satellite glia as a critical component of diabetic neuropathy: Role of lipocalin-2 and pyruvate dehydrogenase kinase-2 axis in the dorsal root ganglion
,Bhusal, A;Rahman, MH;Lee, WH;Lee, IK;Suk, K;,
Glia
,PubMed ID 33251681
[PDK2]
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Other Versions
| SKU | Description | Size | Price |
|---|---|---|---|
| MG206400 | Pdk2 (tGFP-tagged) - Mouse pyruvate dehydrogenase kinase, isoenzyme 2 (Pdk2) |
CNY 3,140.00 |
|
| MR206400 | Pdk2 (Myc-DDK-tagged) - Mouse pyruvate dehydrogenase kinase, isoenzyme 2 (Pdk2), nuclear gene encoding mitochondrial protein |
CNY 2,850.00 |
|
| MR206400L3 | Lenti ORF clone of Pdk2 (Myc-DDK-tagged) - Mouse pyruvate dehydrogenase kinase, isoenzyme 2 (Pdk2), nuclear gene encoding mitochondrial protein |
CNY 4,750.00 |
|
| MR206400L4 | Lenti ORF clone of Pdk2 (mGFP-tagged) - Mouse pyruvate dehydrogenase kinase, isoenzyme 2 (Pdk2), nuclear gene encoding mitochondrial protein |
CNY 4,750.00 |
