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App (NM_007471) Mouse Untagged Clone
CAT＃: MC202511
App (untagged) - Mouse amyloid beta (A4) precursor protein (App), transcript variant 2, (10ug)
CNY 5,096.00
Product images
Specifications
| Product Data | |
| Type | Mouse Untagged Clone |
| Tag | Tag Free |
| Synonyms | Abeta; Abpp; Adap; Ag; betaApp; Cvap; E030013M08Rik |
| Vector | PCMV6-Kan/Neo |
| E. coli Selection | Kanamycin (25 ug/mL) |
| Mammalian Cell Selection | Neomycin |
| Sequence Data |
>BC070409 sequence for NM_007471
GTTTCCTCGGCGGCGGGAGGCGAGAGCACCGGGAGCAGAGCGAGCGCGGGGCCACCGGAGACGGCGGCGG CGGCGCGGACACAGCCAGGGCGCGGCGGATCTTCCACTCGCACACGGAGCACTCGGTGGCCCACGCAGGA TCACGATGCTGCCCAGCTTGGCACTGCTCCTGCTGGCCGCCTGGACGGTTCGGGCTCTGGAGGTACCCAC TGATGGCAACGCCGGGCTGCTGGCAGAACCCCAGATCGCCATGTTCTGTGGTAAACTCAACATGCACATG AATGTGCAGAATGGAAAGTGGGAGTCAGACCCGTCAGGGACCAAAACCTGCATTGGCACCAAGGAGGGCA TCTTGCAGTACTGCCAAGAGGTCTACCCTGAACTGCAGATCACAAACGTGGTGGAAGCCAACCAGCCAGT GACCATCCAGAACTGGTGCAAGCGGGGCCGCAAGCAGTGCAAGACACACACCCACATCGTGATTCCTTAC CGTTGCCTAGTTGGTGAGTTTGTGAGCGACGCCCTTCTCGTGCCCGACAAGTGCAAGTTCCTACACCAGG AGCGGATGGATGTTTGTGAGACCCATCTTCACTGGCACACCGTCGCCAAAGAGACATGCAGCGAGAAGAG CACTAACTTGCACGACTATGGCATGCTGCTGCCCTGCGGCATCGACAAGTTCCGAGGGGTAGAGTTTGTA TGCTGCCCGTTGGCCGAGGAAAGCGACAGCGTGGATTCTGCGGATGCAGAGGAGGATGACTCTGATGTCT GGTGGGGTGGAGCGGACACAGACTACGCTGATGGCGGTGAAGACAAAGTAGTAGAAGTCGCCGAAGAGGA GGAAGTGGCTGATGTTGAGGAAGAGGAAGCTGATGATGATGAGGATGTGGAGGATGGGGACGAGGTGGAG GAGGAGGCCGAGGAGCCCTACGAAGAGGCCACCGAGAGAACAACCAGCACTGCCACCACCACCACAACCA CCACTGAGTCCGTGGAGGAGGTGGTCCGAGTTCCCACGACAGCAGCCAGCACCCCCGACGCCGTCGACAA GTACCTGGAGACACCCGGGGACGAGAACGAGCATGCCCATTTCCAGAAAGCCAAAGAGAGGCTGGAAGCC AAGCACCGAGAGAGAATGTCCCAGGTCATGAGAGAATGGGAAGAGGCAGAGCGTCAAGCCAAGAACTTGC CCAAAGCTGACAAGAAGGCCGTTATCCAGCATTTCCAGGAGAAAGTGGAATCTCTGGAACAGGAAGCAGC CAATGAGAGACAGCAGCTTGTAGAGACACACATGGCCAGAGTTGAAGCCATGCTCAATGACCGCCGCCGC CTGGCCCTCGAGAATTACATCACTGCACTGCAGGCGGTGCCCCCAAGGCCTCATCATGTGTTCAACATGC TGAAGAAGTACGTCCGTGCGGAGCAGAAAGACAGACAGCACACCCTAAAGCATTTTGAACATGTGCGCAT GGTGGACCCCAAGAAAGCTGCTCAGATCCGGTCCCAGGTTATGACACACCTCCGTGTGATCTACGAGCGC ATGAACCAGTCTCTGTCCCTGCTCTACAATGTCCCTGCGGTGGCTGAGGAGATTCAAGATGAAGTCGATG AGCTGCTTCAGAAGGAGCAGAACTACTCCGACGATGTCTTGGCCAACATGATCAGTGAGCCCAGAATCAG CTACGGAAACGACGCTCTCATGCCTTCGCTGACGGAAACCAAGACCACCGTGGAGCTCCTTCCCGTGAAT GGGGAATTCAGCCTGGATGACCTCCAGCCGTGGCACCCTTTTGGGGTGGACTCTGTGCCAGCCAATACCG AAAATGAAGTCGAGCCTGTTGACGCCCGCCCCGCTGCTGACCGAGGACTGACCACTCGACCAGGTTCTGG GCTGACAAACATCAAGACGGAAGAGATCTCGGAAGTGAAGATGGATGCAGAATTCGGACATGATTCAGGA TTTGAAGTCCGCCATCAAAAACTGGTGTTCTTTGCTGAAGATGTGGGTTCGAACAAAGGCGCCATCATCG GACTCATGGTGGGCGGCGTTGTCATAGCAACCGTGATTGTCATCACCCTGGTGATGTTGAAGAAGAAACA GTACACATCCATCCATCATGGCGTGGTGGAGGTCGACGCCGCCGTGACCCCAGAGGAGCGCCATCTCTCC AAGATGCAGCAGAACGGATATGAGAATCCAACTTACAAGTTCTTTGAGCAAATGCAGAACTAAGCCCCAC CCGCGCCACAGCAGCGGCCTCTGAACTTGGACAGCGAAACCATTGCTTCACTACCCATCGGTGTTCATTT ATAAAATAACGTGGAAAGAAACAAACCCTTCCGTTTATTTACTCACCCTCGGCTTTTGACAGCTGTGCTG TAACACAAGTAGATGCCTGAACTTGAATTAATATACAAATCAGTAATGTATTCTCGCTTTCTCTCTTTAC ATTCTGGTCTCTACATTACATGATTCATGGGTTTTGTGTACTGTAAAAAAAAAAATTAGCTGTATCAAAC TAGTGCATGAATAGATTCTCTCCTAATTATTTATCACATACATAGCCCCTTAGCCCGTTGTATATTATTC TTGTGGTTTGTGGCCCGGAAAAAACTCCTACTTGAAATATGCTTTAAAAATCGATGGGGGATGCTTCTTG TGAACGTGGGCGTCTAGCTGCTTCTCCTACGTATTCTTTTCCTGATCACTATGCATTTTGAACATTTTTT TAAGTATTCCAAATGACTTAGAAAATTCTTTTTCCATGACTGCATCTTACTGTACAGATTGCTGCTTCTG CTCTCTTTGTGATATAGGAATAAGAGGATACACATTGATTTCTTTGTGCCTGTTTTATGTGCACACATTA GGCATTGAGAATTTGAACATTTTTTTTGTCCATGTATCTTTGGATCTTTGATAAAAAAAAATTAAAAAAA AATTATCCCTGTTCATCATAAGCACTTTTACGGGTGGGGGGAGGGAGTGTTCTGCTGGTCTCCAATTACC AAGAATTCTCCAAAAATTAATTTTCTGCAGGATGATTGTACAGAATCATTGCTTATGCCATGATAGCTTT CTACACTGTATTACATAAATAAATTAAATAAAATAACTCCAAAAAAAAAAAAAAAAAAAA |
| Restriction Sites | AscI-NotI |
| ACCN | NM_007471 |
| Insert Size | 2088 bp |
| OTI Disclaimer | Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP). |
| Product Components | The ORF clone is ion-exchange column purified and shipped in a 2D barcoded Matrix tube containing 10ug of transfection-ready, dried plasmid DNA (reconstitute with 100 ul of water). |
| Reconstitution | 1. Centrifuge at 5,000xg for 5min. 2. Carefully open the tube and add 100ul of sterile water to dissolve the DNA. 3. Close the tube and incubate for 10 minutes at room temperature. 4. Briefly vortex the tube and then do a quick spin (less than 5000xg) to concentrate the liquid at the bottom. 5. Store the suspended plasmid at -20°C. The DNA is stable for at least one year from date of shipping when stored at -20°C. |
| Note | Plasmids are not sterile. For experiments where strict sterility is required, filtration with 0.22um filter is required. |
| Reference Data | |
| RefSeq | BC070409, AAH70409 |
| RefSeq Size | 3140 bp |
| RefSeq ORF | 2088 bp |
| Locus ID | 11820 |
| Gene Summary | Functions as a cell surface receptor and performs physiological functions on the surface of neurons relevant to neurite growth, neuronal adhesion and axonogenesis. Interaction between APP molecules on neighboring cells promotes synaptogenesis. Involved in cell mobility and transcription regulation through protein-protein interactions. Can promote transcription activation through binding to APBB1-KAT5 and inhibit Notch signaling through interaction with Numb. Couples to apoptosis-inducing pathways such as those mediated by G(O) and JIP. Inhibits G(o) alpha ATPase activity (By similarity). Acts as a kinesin I membrane receptor, mediating the axonal transport of beta-secretase and presenilin 1. May be involved in copper homeostasis/oxidative stress through copper ion reduction. Can regulate neurite outgrowth through binding to components of the extracellular matrix such as heparin and collagen I and IV (By similarity). The splice isoforms that contain the BPTI domain possess protease inhibitor activity. Induces a AGER-dependent pathway that involves activation of p38 MAPK, resulting in internalization of amyloid-beta peptide and leading to mitochondrial dysfunction in cultured cortical neurons (By similarity). Provides Cu(2+) ions for GPC1 which are required for release of nitric oxide (NO) and subsequent degradation of the heparan sulfate chains on GPC1.[UniProtKB/Swiss-Prot Function] Transcript Variant: This variant (2) lacks an alternate in-frame exon compared to variant 1. The resulting isoform (2) has the same N- and C-termini but is shorter compared to isoform 1. |
Documents
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Resources
Other Versions
| SKU | Description | Size | Price |
|---|---|---|---|
| MG210090 | App (tGFP-tagged) - Mouse amyloid beta (A4) precursor protein (App) |
CNY 6,696.00 |
|
| MR210090 | App (Myc-DDK-tagged) - Mouse amyloid beta (A4) precursor protein (App), transcript variant 2 |
CNY 5,096.00 |
|
| MR210090L3 | Lenti ORF clone of App (Myc-DDK-tagged) - Mouse amyloid beta (A4) precursor protein (App), transcript variant 2 |
CNY 7,496.00 |
|
| MR210090L4 | Lenti ORF clone of App (mGFP-tagged) - Mouse amyloid beta (A4) precursor protein (App), transcript variant 2 |
CNY 7,496.00 |
