Sesn2 (NM_144907) Mouse Untagged Clone

CAT#: MC200569

Sesn2 (untagged) - Mouse sestrin 2 (Sesn2), (10ug)



  "NM_144907" in other vectors (4)

CNY 2,000.00


货期*
现货

规格
    • 10 ug

Product images

经常一起买 (3)
TurboFectin Transfection Reagent (1 mL in 1 vial)
    • 1 ml in 1 vial

CNY 4,090.00


DH5α Chemically Competent Cells (≥10^8 cfu/μg of pUC19 DNA)
    • 5 x 200 ul

CNY 1,280.00


Forward sequencing primer VP1.5, Reverse sequencing primer XL39, 100pmoles each
    • 100 pmol

CNY 480.00

Specifications

Product Data
Type Mouse Untagged Clone
Tag Tag Free
Synonyms HI95; Ses2; SEST2
Vector PCMV6-Kan/Neo
E. coli Selection Kanamycin (25 ug/mL)
Mammalian Cell Selection Neomycin
Sequence Data
>BC005672 sequence for NM_144907
GGGATGGTGAGGAGCGCCGGCTTCCCGAGCAGCGCTGGCCACTGCGGACTTCCGAGGCACTCCGGGCCGT GAAAACCTCTGCGCCGCGGCCAATCTCAGGCCTCCGAGGCCGGCCGCAGTTTTCCAAGCTGGGCTGAAAG GAGTGTCTATCGCCGTAGCGCCGGTTCTCCTAATCCCGAGAGACAGCCCGGGGATCTCGAGCTTCCCCGG CGACCCCTAGTCCCGGCCTCCTGTGCGCGCCCGACCTAGACCCCTCGGGTGTCCCAGGCGCGGACGAGCC GCGGCCGGGTCCTGGCGTACACCATGATCGTAGCGGACTCCGAGTGCCATTCCGAGATCAAGGGCTACCT GCCGTTCACCAGGGGTGGTGTGGCCGGCCCCGAGACCCGAGAGGAGCATCGGGAGGGCCAGGCTCGGCGA GGCTCTCGAGGGCCCAGCGCTTTCATTCCAGTGGAAGAGATCCTTCGGGAAGGAGCTGAGAGCCTGGAGC AGCACCTGGGGCTCGAGGCCCTGATGTCCTCAGGGCGGGTGGACAACCTGGCGGTGGTGATGGGTCTACA CCCGGACTACCTTAGCAGCTTCTGGCGCCTGCATTACCTGCTGCTGCATACGGATGGGCCCCTGGCCAGC TCCTGGCGCCACTACATTGCCATCATGGCTGCTGCCCGTCACCAGTGTTCTTACCTGGTGGGTTCCCACA TGACTGAGTTCCTGCAGACCGGCGGTGACCCCGAGTGGCTGCTGGGCCTTCACCGGGCCCCTGAGAAGCT CCGCAAGCTCAGCGAGGTCAACAAGTTACTGGCGCATCGGCCGTGGCTCATCACCAAGGAGCATATCCAG GCCTTGCTGAAGACTGGCGAGCACAGCTGGTCCCTGGCCGAACTCATCCAAGCACTGGTCCTGCTTACCC ACTGCCACTCTCTGGCCTCCTTTGTGTTTGGCTGTGGAATACTTCCTGAGGGAGATGCAGAGGGCAGCCC TGCCTCCCAGGCACCTTCGCCTCCCAGTGAGCAAGGCACCCCCCCGAGCGGGGACCCACTGAACAACTCA GGGGGCTTTGAAGCCGCTCGTGACGTAGAAGCTCTGATGGAACGCATGAGGCAGCTTCAGGAGAGCCTGC TGCGGGATGAGGGGGCTTCGCAGGAGGAAATGGAGAACCGTTTTGAGCTGGAGAAGTCAGAAAGCCTGCT GGTGACCCCCTCAGCGGATATCCTGGAGCCTTCTCCACACCCAGACATCCTATGCTTTGTGGAGGACCCC GCATTTGGATATGAAGACTTCACTCGTCGAGGGACTCAGGCGCCCCCAACCTTCCGTGCCCAGGATTATA CCTGGGAAGACCATGGCTACTCGCTGATCCAGAGGCTCTACCCTGAGGGAGGGCAGCTGCTGGATGAGAA GTTCCAGGTAGCCTGCAGCCTCACCTATAACACCATCGCCATGCACAGTGGCGTGGACACCTCCATGCTC CGCAGGGCCATCTGGAACTACATCCACTGCGTCTTTGGCATCAGATACGATGACTATGATTACGGCGAGG TAAACCAGCTCCTGGAACGGAACCTCAAAATCTATATCAAGACGGTGGCCTGCTACCCTGAGAAGACGAC CCGTAGGATGTACAACCTCTTTTGGAGGCACTTCCGCCACTCAGAGAAGGTTCATGTGAACTTGCTGCTC CTTGAAGCCCGCATGCAAGCGGCCCTGCTCTATGCCCTGCGCGCCATCACCCGCTACATGACCTGACTAC CCCGTACGCAGGACCAGCACCAGGAGCAGCTGACCCTGGTCCACCGTCCTCTGTGCAAGGACTTCTGTGT CTGGAGACAGATCTGGGAAGGACCCTTTCTGTCTCATGTCTATCCACCACATGCTGGGGATGGGCATGTC TGTGGCCCCAGGCAGCCATCAGGGCAAGCCACATTTTCCTTTTCCTCACTGGACTGAACAGGACCGTCGC ACTGACTTTGGGGTCTGAGCTCTGTACCTGGAGCTGGAAGAAGATTCGGAAAGGCCAAGGGCCACATCCC CTTTTCTTCCCCTGCTCCTAAAAGCAGAGGAAGGCTACAGAGCTAAGGCTGGGCCCCAGGCACCACAAAA GCTGCCTTCCTGGACTGGGAAGCCCCTGGCTGCCTGTGTGGGAGAGGAGTAAGGACCTCCAGGGACTAGC ACTCCAGGAAGTTTGCCTTCCCGCCTTCCCTCCTTCCTCATTCTCCAGTTTCATCAGCCCCCCAACCTGC CTCCCACCCATCAATGTGAAAGTTGGACTCACAGCTGGTCTGTGTGCCCAGTTCCCCTAGAGCCTGTTCT GCTGGGCAGCCTGTTCTTTGGTTACCTGAGTAGGGGTTCAGTTCTTCTGTCTCCTTTGCCCTCATACCCT TTTCTCCCATGCCTGGTGGTGTGGGGCCTGGGAGAGGGGCCAAACATATCCAAAGAACACACTGTCTCTG GAGAGTTGGAGCCCGTGGTGGTCTCCCTGCTGTCTGAAGAGTAAGGAGTGGCTGTTGGTGAACTCTGTAT TTGGGTCTTGAGGACCTCACTGTGGAGCCAGAGTCAATCTGTCCCTCTAGATGGTATTGCCACACGGAGG CTGGCATCCTGACCTCCTTATCCCTTGGGTTCTGCCAAGAATGCTTGCCAAAAACAAACAAACAAAAAAA AAAAAAAAAAAAAAAAA
Restriction Sites RsrII-NotI     
ACCN NM_144907
Insert Size 1443 bp
OTI Disclaimer Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP).
Product Components The ORF clone is ion-exchange column purified and shipped in a 2D barcoded Matrix tube containing 10ug of transfection-ready, dried plasmid DNA (reconstitute with 100 ul of water).
Reconstitution 1. Centrifuge at 5,000xg for 5min.
2. Carefully open the tube and add 100ul of sterile water to dissolve the DNA.
3. Close the tube and incubate for 10 minutes at room temperature.
4. Briefly vortex the tube and then do a quick spin (less than 5000xg) to concentrate the liquid at the bottom.
5. Store the suspended plasmid at -20°C. The DNA is stable for at least one year from date of shipping when stored at -20°C.
Reference Data
RefSeq BC005672, AAH05672
RefSeq Size 2677 bp
RefSeq ORF 1443 bp
Locus ID 230784
UniProt ID P58043
Gene Summary Functions as an intracellular leucine sensor that negatively regulates the TORC1 signaling pathway through the GATOR complex. In absence of leucine, binds the GATOR subcomplex GATOR2 and prevents TORC1 signaling. Binding of leucine to SESN2 disrupts its interaction with GATOR2 thereby activating the TORC1 signaling pathway (PubMed:18692468, PubMed:25259925). This stress-inducible metabolic regulator also plays a role in protection against oxidative and genotoxic stresses. May negatively regulate protein translation in response to endoplasmic reticulum stress, via TORC1 (PubMed:24947615). May positively regulate the transcription by NFE2L2 of genes involved in the response to oxidative stress by facilitating the SQSTM1-mediated autophagic degradation of KEAP1 (PubMed:23274085). May also mediate TP53 inhibition of TORC1 signaling upon genotoxic stress (PubMed:18692468). Has an alkylhydroperoxide reductase activity born by the N-terminal domain of the protein (By similarity). Was originally reported to contribute to oxidative stress resistance by reducing PRDX1 (By similarity). However, this could not be confirmed (By similarity).[UniProtKB/Swiss-Prot Function]
*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.

Other Versions

Customer Reviews 
Loading...