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Sesn2 (NM_144907) Mouse Untagged Clone
CAT＃: MC200569
Sesn2 (untagged) - Mouse sestrin 2 (Sesn2), (10ug)
CNY 3,656.00
Product images
Specifications
| Product Data | |
| Type | Mouse Untagged Clone |
| Tag | Tag Free |
| Synonyms | HI95; Ses2; SEST2 |
| Vector | PCMV6-Kan/Neo |
| E. coli Selection | Kanamycin (25 ug/mL) |
| Mammalian Cell Selection | Neomycin |
| Sequence Data |
>BC005672 sequence for NM_144907
GGGATGGTGAGGAGCGCCGGCTTCCCGAGCAGCGCTGGCCACTGCGGACTTCCGAGGCACTCCGGGCCGT GAAAACCTCTGCGCCGCGGCCAATCTCAGGCCTCCGAGGCCGGCCGCAGTTTTCCAAGCTGGGCTGAAAG GAGTGTCTATCGCCGTAGCGCCGGTTCTCCTAATCCCGAGAGACAGCCCGGGGATCTCGAGCTTCCCCGG CGACCCCTAGTCCCGGCCTCCTGTGCGCGCCCGACCTAGACCCCTCGGGTGTCCCAGGCGCGGACGAGCC GCGGCCGGGTCCTGGCGTACACCATGATCGTAGCGGACTCCGAGTGCCATTCCGAGATCAAGGGCTACCT GCCGTTCACCAGGGGTGGTGTGGCCGGCCCCGAGACCCGAGAGGAGCATCGGGAGGGCCAGGCTCGGCGA GGCTCTCGAGGGCCCAGCGCTTTCATTCCAGTGGAAGAGATCCTTCGGGAAGGAGCTGAGAGCCTGGAGC AGCACCTGGGGCTCGAGGCCCTGATGTCCTCAGGGCGGGTGGACAACCTGGCGGTGGTGATGGGTCTACA CCCGGACTACCTTAGCAGCTTCTGGCGCCTGCATTACCTGCTGCTGCATACGGATGGGCCCCTGGCCAGC TCCTGGCGCCACTACATTGCCATCATGGCTGCTGCCCGTCACCAGTGTTCTTACCTGGTGGGTTCCCACA TGACTGAGTTCCTGCAGACCGGCGGTGACCCCGAGTGGCTGCTGGGCCTTCACCGGGCCCCTGAGAAGCT CCGCAAGCTCAGCGAGGTCAACAAGTTACTGGCGCATCGGCCGTGGCTCATCACCAAGGAGCATATCCAG GCCTTGCTGAAGACTGGCGAGCACAGCTGGTCCCTGGCCGAACTCATCCAAGCACTGGTCCTGCTTACCC ACTGCCACTCTCTGGCCTCCTTTGTGTTTGGCTGTGGAATACTTCCTGAGGGAGATGCAGAGGGCAGCCC TGCCTCCCAGGCACCTTCGCCTCCCAGTGAGCAAGGCACCCCCCCGAGCGGGGACCCACTGAACAACTCA GGGGGCTTTGAAGCCGCTCGTGACGTAGAAGCTCTGATGGAACGCATGAGGCAGCTTCAGGAGAGCCTGC TGCGGGATGAGGGGGCTTCGCAGGAGGAAATGGAGAACCGTTTTGAGCTGGAGAAGTCAGAAAGCCTGCT GGTGACCCCCTCAGCGGATATCCTGGAGCCTTCTCCACACCCAGACATCCTATGCTTTGTGGAGGACCCC GCATTTGGATATGAAGACTTCACTCGTCGAGGGACTCAGGCGCCCCCAACCTTCCGTGCCCAGGATTATA CCTGGGAAGACCATGGCTACTCGCTGATCCAGAGGCTCTACCCTGAGGGAGGGCAGCTGCTGGATGAGAA GTTCCAGGTAGCCTGCAGCCTCACCTATAACACCATCGCCATGCACAGTGGCGTGGACACCTCCATGCTC CGCAGGGCCATCTGGAACTACATCCACTGCGTCTTTGGCATCAGATACGATGACTATGATTACGGCGAGG TAAACCAGCTCCTGGAACGGAACCTCAAAATCTATATCAAGACGGTGGCCTGCTACCCTGAGAAGACGAC CCGTAGGATGTACAACCTCTTTTGGAGGCACTTCCGCCACTCAGAGAAGGTTCATGTGAACTTGCTGCTC CTTGAAGCCCGCATGCAAGCGGCCCTGCTCTATGCCCTGCGCGCCATCACCCGCTACATGACCTGACTAC CCCGTACGCAGGACCAGCACCAGGAGCAGCTGACCCTGGTCCACCGTCCTCTGTGCAAGGACTTCTGTGT CTGGAGACAGATCTGGGAAGGACCCTTTCTGTCTCATGTCTATCCACCACATGCTGGGGATGGGCATGTC TGTGGCCCCAGGCAGCCATCAGGGCAAGCCACATTTTCCTTTTCCTCACTGGACTGAACAGGACCGTCGC ACTGACTTTGGGGTCTGAGCTCTGTACCTGGAGCTGGAAGAAGATTCGGAAAGGCCAAGGGCCACATCCC CTTTTCTTCCCCTGCTCCTAAAAGCAGAGGAAGGCTACAGAGCTAAGGCTGGGCCCCAGGCACCACAAAA GCTGCCTTCCTGGACTGGGAAGCCCCTGGCTGCCTGTGTGGGAGAGGAGTAAGGACCTCCAGGGACTAGC ACTCCAGGAAGTTTGCCTTCCCGCCTTCCCTCCTTCCTCATTCTCCAGTTTCATCAGCCCCCCAACCTGC CTCCCACCCATCAATGTGAAAGTTGGACTCACAGCTGGTCTGTGTGCCCAGTTCCCCTAGAGCCTGTTCT GCTGGGCAGCCTGTTCTTTGGTTACCTGAGTAGGGGTTCAGTTCTTCTGTCTCCTTTGCCCTCATACCCT TTTCTCCCATGCCTGGTGGTGTGGGGCCTGGGAGAGGGGCCAAACATATCCAAAGAACACACTGTCTCTG GAGAGTTGGAGCCCGTGGTGGTCTCCCTGCTGTCTGAAGAGTAAGGAGTGGCTGTTGGTGAACTCTGTAT TTGGGTCTTGAGGACCTCACTGTGGAGCCAGAGTCAATCTGTCCCTCTAGATGGTATTGCCACACGGAGG CTGGCATCCTGACCTCCTTATCCCTTGGGTTCTGCCAAGAATGCTTGCCAAAAACAAACAAACAAAAAAA AAAAAAAAAAAAAAAAA |
| Restriction Sites | RsrII-NotI |
| ACCN | NM_144907 |
| Insert Size | 1443 bp |
| OTI Disclaimer | Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP). |
| Product Components | The ORF clone is ion-exchange column purified and shipped in a 2D barcoded Matrix tube containing 10ug of transfection-ready, dried plasmid DNA (reconstitute with 100 ul of water). |
| Reconstitution | 1. Centrifuge at 5,000xg for 5min. 2. Carefully open the tube and add 100ul of sterile water to dissolve the DNA. 3. Close the tube and incubate for 10 minutes at room temperature. 4. Briefly vortex the tube and then do a quick spin (less than 5000xg) to concentrate the liquid at the bottom. 5. Store the suspended plasmid at -20°C. The DNA is stable for at least one year from date of shipping when stored at -20°C. |
| Note | Plasmids are not sterile. For experiments where strict sterility is required, filtration with 0.22um filter is required. |
| Reference Data | |
| RefSeq | BC005672, AAH05672 |
| RefSeq Size | 2677 bp |
| RefSeq ORF | 1443 bp |
| Locus ID | 230784 |
| UniProt ID | P58043 |
| Gene Summary | Functions as an intracellular leucine sensor that negatively regulates the TORC1 signaling pathway through the GATOR complex. In absence of leucine, binds the GATOR subcomplex GATOR2 and prevents TORC1 signaling. Binding of leucine to SESN2 disrupts its interaction with GATOR2 thereby activating the TORC1 signaling pathway (PubMed:18692468, PubMed:25259925). This stress-inducible metabolic regulator also plays a role in protection against oxidative and genotoxic stresses. May negatively regulate protein translation in response to endoplasmic reticulum stress, via TORC1 (PubMed:24947615). May positively regulate the transcription by NFE2L2 of genes involved in the response to oxidative stress by facilitating the SQSTM1-mediated autophagic degradation of KEAP1 (PubMed:23274085). May also mediate TP53 inhibition of TORC1 signaling upon genotoxic stress (PubMed:18692468). Has an alkylhydroperoxide reductase activity born by the N-terminal domain of the protein (By similarity). Was originally reported to contribute to oxidative stress resistance by reducing PRDX1 (By similarity). However, this could not be confirmed (By similarity).[UniProtKB/Swiss-Prot Function] |
Documents
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Resources
Other Versions
| SKU | Description | Size | Price |
|---|---|---|---|
| MG207693 | Sesn2 (tGFP-tagged) - Mouse sestrin 2 (Sesn2) |
CNY 5,256.00 |
|
| MR207693 | Sesn2 (Myc-DDK-tagged) - Mouse sestrin 2 (Sesn2) |
CNY 3,656.00 |
|
| MR207693L3 | Lenti ORF clone of Sesn2 (Myc-DDK-tagged) - Mouse sestrin 2 (Sesn2) |
CNY 6,180.00 |
|
| MR207693L4 | Lenti ORF clone of Sesn2 (mGFP-tagged) - Mouse sestrin 2 (Sesn2) |
CNY 6,180.00 |
