PTP1B (PTPN1) (NM_002827) Human 3' UTR Clone

Specifications

Product Data
Product Name	PTP1B (PTPN1) (NM_002827) Human 3' UTR Clone
Vector	pMirTarget
Synonyms	PTP1B
ACCN	NM_002827
Insert Size	2000 bp
Sequence Data	Insert Sequence (showhide) >SC216694 3’UTR clone of NM_002827 The sequence shown below is from the reference sequence of NM_002827. The complete sequence of this clone may contain minor differences, such as SNPs. Blue=Stop Codon Red=Cloning site GGCAAGTTGGACGCCCGCAAGATCCGCGAGATTCTCATTAAGGCCAAGAAGGGCGGAAAGATCGCCGTG TAACAATTGGCAGAGCTCAGAATTCAAGCGATCGCC TACAGGTTCCTGTTCAACAGCAACACATAGCCTGACCCTCCTCCACTCCACCTCCACCCACTGTCCGCC TCTGCCCGCAGAGCCCACGCCCGACTAGCAGGCATGCCGCGGTAGGTAAGGGCCGCCGGACCGCGTAGA GAGCCGGGCCCCGGACGGACGTTGGTTCTGCACTAAAACCCATCTTCCCCGGATGTGTGTCTCACCCCT CATCCTTTTACTTTTTGCCCCTTCCACTTTGAGTACCAAATCCACAAGCCATTTTTTGAGGAGAGTGAA AGAGAGTACCATGCTGGCGGCGCAGAGGGAAGGGGCCTACACCCGTCTTGGGGCTCGCCCCACCCAGGG CTCCCTCCTGGAGCATCCCAGGCGGGCGGCACGCCAACAGCCCCCCCCTTGAATCTGCAGGGAGCAACT CTCCACTCCATATTTATTTAAACAATTTTTTCCCCAAAGGCATCCATAGTGCACTAGCATTTTCTTGAA CCAATAATGTATTAAAATTTTTTGATGTCAGCCTTGCATCAAGGGCTTTATCAAAAAGTACAATAATAA ATCCTCAGGTAGTACTGGGAATGGAAGGCTTTGCCATGGGCCTGCTGCGTCAGACCAGTACTGGGAAGG AGGACGGTTGTAAGCAGTTGTTATTTAGTGATATTGTGGGTAACGTGAGAAGATAGAACAATGCTATAA TATATAATGAACACGTGGGTATTTAATAAGAAACATGATGTGAGATTACTTTGTCCCGCTTATTCTCCT CCCTGTTATCTGCTAGATCTAGTTCTCAATCACTGCTCCCCCGTGTGTATTAGAATGCATGTAAGGTCT TCTTGTGTCCTGATGAAAAATATGTGCTTGAAATGAGAAACTTTGATCTCTGCTTACTAATGTGCCCCA TGTCCAAGTCCAACCTGCCTGTGCATGACCTGATCATTACATGGCTGTGGTTCCTAAGCCTGTTGCTGA AGTCATTGTCGCTCAGCAATAGGGTGCAGTTTTCCAGGAATAGGCATTTGCCTAATTCCTGGCATGACA CTCTAGTGACTTCCTGGTGAGGCCCAGCCTGTCCTGGTACAGCAGGGTCTTGCTGTAACTCAGACATTC CAAGGGTATGGGAAGCCATATTCACACCTCACGCTCTGGACATGATTTAGGGAAGCAGGGACACCCCCC GCCCCCCACCTTTGGGATCAGCCTCCGCCATTCCAAGTCAACACTCTTCTTGAGCAGACCGTGATTTGG AAGAGAGGCACCTGCTGGAAACCACACTTCTTGAAACAGCCTGGGTGACGGTCCTTTAGGCAGCCTGCC GCCGTCTCTGTCCCGGTTCACCTTGCCGAGAGAGGCGCGTCTGCCCCACCCTCAAACCCTGTGGGGCCT GATGGTGCTCACGACTCTTCCTGCAAAGGGAACTGAAGACCTCCACATTAAGTGGCTTTTTAACATGAA AAACACGGCAGCTGTAGCTCCCGAGCTACTCTCTTGCCAGCATTTTCACATTTTGCCTTTCTCGTGGTA GAAGCCAGTACAGAGAAATTCTGTGGTGGGAACATTCGAGGTGTCACCCTGCAGAGCTATGGTGAGGTG TGGATAAGGCTTAGGTGCCAGGCTGTAAGCATTCTGAGCTGGGCTTGTTGTTTTTAAGTCCTGTATATG TATGTAGTAGTTTGGGTGTGTATATATAGTAGCATTTCAAAATGGACGTACTGGTTTAACCTCCTATCC TTGGAGAGCAGCTGGCTCTCCACCTTGTTACACATTATGTTAGAGAGGTAGCGAGCTGCTCTGCTATAT GCCTTAAGCCAATATTTACTCATCAGGTCATTATTTTTTACAATGGCCATGGAATAAACCATTTTTACA AAAATAAAAACAAAAAAAGCAAGGTGTTTTGGTATAATACCTTTTCAGGTGTGTGTGGATACGTGGCTG CATGACCGGGTGGGTGGGGGGGAGTGTCTCAGGGTCTTCTGTGACCTCACAGAACTGTCAGACTGTAC ACGCGTAAGCGGCCGCGGCATCTAGATTCGAAGAAAATGACCGACCAAGCGACGCCCAACCTGCCATCA CGAGATTTCGATTCCACCGCCGCCTTCTATGAAAGG
Restriction Sites	SgfI-MluI
OTI Disclaimer	Our molecular clone sequence data has been matched to the sequence identifier above as a point of reference. Note that the complete sequence of this clone is largely the same as the reference sequence but may contain minor differences , e.g., single nucleotide polymorphisms (SNPs).
Reference Data
RefSeq	NM_002827.4
Synonyms	PTP1B
Summary	The protein encoded by this gene is the founding member of the protein tyrosine phosphatase (PTP) family, which was isolated and identified based on its enzymatic activity and amino acid sequence. PTPs catalyze the hydrolysis of the phosphate monoesters specifically on tyrosine residues. Members of the PTP family share a highly conserved catalytic motif, which is essential for the catalytic activity. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP has been shown to act as a negative regulator of insulin signaling by dephosphorylating the phosphotryosine residues of insulin receptor kinase. This PTP was also reported to dephosphorylate epidermal growth factor receptor kinase, as well as JAK2 and TYK2 kinases, which implicated the role of this PTP in cell growth control, and cell response to interferon stimulation. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2013]
Locus ID	5770
MW	74.6

*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.