ULK1 (NM_003565) Human 3' UTR Clone

Specifications

Product Data
Product Name	ULK1 (NM_003565) Human 3' UTR Clone
Vector	pMirTarget
Synonyms	ATG1; ATG1A; hATG1; UNC51; Unc51.1
ACCN	NM_003565
Insert Size	1819 bp
Sequence Data	Insert Sequence (showhide) >SC216600 3’UTR clone of NM_003565 The sequence shown below is from the reference sequence of NM_003565. The complete sequence of this clone may contain minor differences, such as SNPs. Blue=Stop Codon Red=Cloning site GGCAAGTTGGACGCCCGCAAGATCCGCGAGATTCTCATTAAGGCCAAGAAGGGCGGAAAGATCGCCGTG TAACAATTGGCAGAGCTCAGAATTCAAGCGATCGCC TCGGCGCTGCTGACTGGCATCTGTGCCTGACCTTTCTGGCCTGGCTGGGCCCCCCGTCCTGCCGAGCCC TGCAGAGTGGGCTCTGTGTGCTGGCTGGACTCCTCGGGACAAGCCCATGGCGCTGATCGCTGGTGCTGA GCCCTGCCCTGGGCCCCACGGACAGTCAGCCTGCCGGCCTCCCTGCAGCTCACGGGGCAGAACCAGCAC ATCTGGAGCCACACAGCTTGGGGGGTGTCTCCCATCTTTTACAGGTGGGGATCACAGAATTTCTGCCCC TCCAGCTGCCTGGCTCAGCAGGCGTGGGTGCCACCACCCTCTAGCCCCAGGGCAGCCCCGGAGGACAGG CAAGGGCCTGAGACCACTGCCGACTCAAAGCCAAAGCGAGCTCCTGCTTAGGGAAGGTCAGCAGGCACT GTGCCCAGGAAGAGCCTGCGGCCTCGGCGTCCCCCAGTCTCCAGGAGCCTCTCCCTCCGAGATACCCAC CCAGCTTTGTCAATCACCCAAGCACTTTATGCATATAGAGACAGAACCTGGACCTCACCAGGGACTGCT GGGCAGCGATTCCTGGCAGTGGCCTGGTGTTTGTACATACACATATGCAGACACATGCCAGGGCCCCCC AAGCCCGAGCACCGGACCACGTTGCTGCCCAGGTCTGGACCTCAGCGGGAGAACTGGCTCCGGGGGGAG TGGGGCCCTGCGCTAGAGGCAGAGGCAGTTCTTTGTTCAAGCGTTCCTCTGGGGACCGGCAGCAGAGGC ACCGTGTTCTCTCAGCCCTGGATACGTCTTGTAATCTTTCACACTTTATTCCTAAAACGTGTCTTATTT TTATGCAGCTCATTTTTTCTTTAAAGGAGAAAACTTGTAGGTGTTTAAGAATTGGTTTTGGGAGGGCGA GGACTGGGCCAGGTTAGAGGCAGATGGCACAGGGGCGTGTGGCGGGCGGGTGAGGCTGCTTTGCACACC TGTGTTGGTGGCTGTCCCCTGCCGCCCCTCCCTGTGGCAGCAGCAGGACAGGTGTGTGCCCAGCACCCT CCCTACCTGGGCCTGGAAGCAGATGAGGGGAATACTTCATGCAAAGAAAAAAGTAACATGTGCAAAAGC TCCCCGTCCAGCTTTGACAGTCAGTTTTGATGTCAGCTCCTCGGCAGGGTAGGCCTGATGACAGCCCTG TCCCTCCCTGCCTCTGCCTTGCCCAAGGCCACGGAGGGCATCTGCAGAGAGGCCTGCCTTCCGGATTCC AGGCGGGCATGCCCTGCAAACCCCGCCTGGGCCTCCCTTGGTCTGCCCAGCCCTCGATTAGCCCTGCCT GAATCAGTAGATACTTGAACGAGTCCCCAGTCTGCGGGAGGCAGTGGTGGGGCCATGGACCCATGCGGG GGGTTCCAGGGTCACACGCCACATAACAGACAAAAATACACACACGTGTGTTTTTCTTTGCAATACTTG AAATATTGCCACTGTGCTTGGACTTAGAAGAAGAAAATCCCCGTGACTTCTTCCTCATCACCTTGATGG CTTTATTCTCACCTTGTGGGGCATGTTTGTATTTATTGCTTCATGGCCGACTGGAATCCTGAGTCCTGG GAAGCTGGCACTGCGGGGATCTTGCCCGGTGTCCTGGTCCTCTTGCTTCCGTCGCGGCCGCATGTGCGT GTGTCCAAGCAGGTCCTGGGCGCCTCAACTGCTGCCCCTGGTTGAATGTTCTCTTGATAGTGCTGGACC CTTTGTCTATTTTAAAGCGAATTTTGTGTGATTTCCTGCCCTTTGCGTTATATTGTATAATACCAACGT AAGGAAATAAACCTTTGGAATTGTT ACGCGTAAGCGGCCGCGGCATCTAGATTCGAAGAAAATGACCGACCAAGCGACGCCCAACCTGCCATCA CGAGATTTCGATTCCACCGCCGCCTTCTATGAAAGG
Restriction Sites	SgfI-MluI
OTI Disclaimer	Our molecular clone sequence data has been matched to the sequence identifier above as a point of reference. Note that the complete sequence of this clone is largely the same as the reference sequence but may contain minor differences , e.g., single nucleotide polymorphisms (SNPs).
Reference Data
RefSeq	NM_003565.4
Synonyms	ATG1; ATG1A; hATG1; UNC51; Unc51.1
Summary	Serine/threonine-protein kinase involved in autophagy in response to starvation. Acts upstream of phosphatidylinositol 3-kinase PIK3C3 to regulate the formation of autophagophores, the precursors of autophagosomes. Part of regulatory feedback loops in autophagy: acts both as a downstream effector and negative regulator of mammalian target of rapamycin complex 1 (mTORC1) via interaction with RPTOR. Activated via phosphorylation by AMPK and also acts as a regulator of AMPK by mediating phosphorylation of AMPK subunits PRKAA1, PRKAB2 and PRKAG1, leading to negatively regulate AMPK activity. May phosphorylate ATG13/KIAA0652 and RPTOR; however such data need additional evidences. Plays a role early in neuronal differentiation and is required for granule cell axon formation. May also phosphorylate SESN2 and SQSTM1 to regulate autophagy (PubMed:25040165).[UniProtKB/Swiss-Prot Function]
Locus ID	8408
MW	66.3

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