PIP5K1 alpha (PIP5K1A) (NM_003557) Human 3' UTR Clone

Specifications

Product Data
Product Name	PIP5K1 alpha (PIP5K1A) (NM_003557) Human 3' UTR Clone
Vector	pMirTarget
ACCN	NM_003557
Insert Size	1696 bp
Sequence Data	Insert Sequence (showhide) >SC215977 3’UTR clone of NM_003557 The sequence shown below is from the reference sequence of NM_003557. The complete sequence of this clone may contain minor differences, such as SNPs. Blue=Stop Codon Red=Cloning site GGCAAGTTGGACGCCCGCAAGATCCGCGAGATTCTCATTAAGGCCAAGAAGGGCGGAAAGATCGCCGTG TAACAATTGGCAGAGCTCAGAATTCAAGCGATCGCC GAAGTTGCAGAGTCAGAGTTCACCCATTAAGCGCAAAGCCTCAGAAGACCTGGAACAAGATTCTGCCAT CTCTGTGATCCCAAGATGTCAGCCCTTGCCCCAGCAATGCTGAATTTTCTTCTACTTGGTCATCAAAAA AGGAGTGTAATAGAAGTGAGGGGAGCTGCTCCTCCATCTTCTTCCTGAAGAAGAACCTTCTCTCCTTCC TCTTCCTCATGAATGGGCCTTAGTGCCTCAGAGAGTTGAGGACCGCAGCATCCCCTCCACTCCAGAGTT GGGTGGTATGGATTTTCAACTGGCCAACCCTTTGCCTCCACTATTGAATTTTTTTCAGACCCCCATTCT TCATGCTGGAAATGGGATTGCTGGACTTGGCAGCTTTCTTTCCCCTCGTCTTTGACTAGGAACCGGACT CTTAATTTCCTCAGGACAGACTAGCTGGCACATTATCCCTACCTTAGTTCTTTCTCTCTGACTCCTGGA AGAATACTCCTGTAATCTCTGTAAAGGTTTTTGGGGGATAAGGGTGTTTAACCACCTCCCAGCTTTCTT CTTCTTTTTTTTTTTCTGAAAAAAGGAAAAAGCACACAGCACACAATTTCAAGCCATTTTCAGATCAGA ACTCCAGAAGTGTTGACAAGATGCCTATTCGTAGAGTTCCCTCAGAAGAGCCATGGTGTTTATGAAGAG AAGAGTAGTGATTGCTCTGCCAGAAGCAGCTCCTCTTTAAACTCCTCCTCTCTTGATGAATTTCTTAAG GCTGAAGGAATGAAGAGAGTGGGACATGGGGTAATCTTTATCCCTTTTGTTAAAACAGGAGGCAGCCAT GGGCTGGGAGATCATAGCCCTTCCTAGGCAGAATCCTGTTCACTGCCAGGCTATAGTAATTATTACTAT TTTGCAATTTGAAATATATTCTGGTTGTTTTTCTAAATGTGAAGACTTACCAAATGAATTTTAGATCAT TCTCCAGAGGAGATTTTTTTTGCTCTTCTCATCTTTTCCAACAGTGTTCTCCTGTTTGTGGAGCTAAGG TAAAGAGGGGACACTTCTGTCTGTTTAACAGACAGTCCATATCTGTGAGGCCAGCAAATATTTTCTTAA ACTCATGGGGAGACAGCAGATTCTTGCCTTGGTGAGGTCATTGCTGTGCCATATGTCCTACCCCCCTGT CTTCATGCAGGGAAGTTGGAAATGGGGGCTACATATGCCCTCTCCTCCCCGTCTACAAGAGTTGTGGTT TTCCATCTGATCCTTCCACTCTTGTCAGGGGAAGAAGGGGGCCTGGTATCTCAGGCAGATTGTTGAATT CCTGTTCTATCCCTTCTCTATCCCACCCTGCCTTGATAATATGTTAGCCCATACCCCAAATAACTGTCT ATATTAGACACCCCCAGCCAGTTTCTGGCTGCCTGTCTTTGCTGCCATGTTTTTTACAAGAAGGAAAGA ATTCTTGCTATTTTTTTTTCATAATTTACTATTTATGATGTATTTAAGTGTTTTATTAAGGACAGAGTT CTGTTAGGGGTGGGAGGGAATATTTGAGGGAGGGCTGGGTCTTAGGGAAAGGAATGGGGAAGCAACATT TTTATTAAGTGTTACTATTTGCCTCTACTTTGTATTGTTCAGAAATGGCAAATACAATATAAAAGTGAT ATATGGTTTTAATGTAATAAACTTTAATGAGTTATTTAGA ACGCGTAAGCGGCCGCGGCATCTAGATTCGAAGAAAATGACCGACCAAGCGACGCCCAACCTGCCATCA CGAGATTTCGATTCCACCGCCGCCTTCTATGAAAGG
Restriction Sites	SgfI-MluI
OTI Disclaimer	Our molecular clone sequence data has been matched to the sequence identifier above as a point of reference. Note that the complete sequence of this clone is largely the same as the reference sequence but may contain minor differences , e.g., single nucleotide polymorphisms (SNPs).
Reference Data
RefSeq	NM_003557.3
Summary	Catalyzes the phosphorylation of phosphatidylinositol 4-phosphate (PtdIns4P) to form phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2). PtdIns(4,5)P2 is involved in a variety of cellular processes and is the substrate to form phosphatidylinositol 3,4,5-trisphosphate (PtdIns(3,4,5)P3), another second messenger. The majority of PtdIns(4,5)P2 is thought to occur via type I phosphatidylinositol 4-phosphate 5-kinases given the abundance of PtdIns4P. Participates in a variety of cellular processes such as actin cytoskeleton organization, cell adhesion, migration and phagocytosis. Required for membrane ruffling formation, actin organization and focal adhesion formation during directional cell migration by controlling integrin-induced translocation of RAC1 to the plasma membrane. Together with PIP5K1C is required for phagocytosis, but they regulate different types of actin remodeling at sequential steps. Promotes particle ingestion by activating WAS that induces Arp2/3 dependent actin polymerization at the nascent phagocytic cup. Together with PIP5K1B is required after stimulation of G-protein coupled receptors for stable platelet adhesion. Plays a role during calcium-induced keratinocyte differentiation. Recruited to the plasma membrane by the E-cadherin/beta-catenin complex where it provides the substrate PtdIns(4,5)P2 for the production of PtdIns(3,4,5)P3, diacylglycerol and inositol 1,4,5-trisphosphate that mobilize internal calcium and drive keratinocyte differentiation. Together with PIP5K1C have a role during embryogenesis. Functions also in the nucleus where acts as an activator of TUT1 adenylyltransferase activity in nuclear speckles, thereby regulating mRNA polyadenylation of a select set of mRNAs (PubMed:18288197, PubMed:19158393, PubMed:20660631). Positively regulates insulin-induced translocation of SLC2A4 to the cell membrane in adipocytes (By similarity).[UniProtKB/Swiss-Prot Function]
Locus ID	8394
MW	63.2

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