GPR124 (ADGRA2) (NM_032777) Human 3' UTR Clone

Specifications

Product Data
Product Name	GPR124 (ADGRA2) (NM_032777) Human 3' UTR Clone
Vector	pMirTarget
Synonyms	GPR124; TEM5
ACCN	NM_032777
Insert Size	2000 bp
Sequence Data	Insert Sequence (showhide) >SC215717 3’UTR clone of NM_032777 The sequence shown below is from the reference sequence of NM_032777. The complete sequence of this clone may contain minor differences, such as SNPs. Blue=Stop Codon Red=Cloning site GGCAAGTTGGACGCCCGCAAGATCCGCGAGATTCTCATTAAGGCCAAGAAGGGCGGAAAGATCGCCGTG TAACAATTGGCAGAGCTCAGAATTCAAGCGATCGCC GGACTCTGGAAGAGCGAAACTACCGTCTAAGGTGGGGCGGGCGACGCGGTAGACGGGCTGGCCACGCGG CTCGTTCCCCCGCTCCTCGGGGCCCTCCAAGGTGTCTCCGTAGTCAGCAGGTTGGAGGCAGAGGAGCCG ATGGCTGGAGGAAGCCCACAGGCGGATGTTCCCCACTTGCCTAGAGGGCATCCCTCTGGGGTAGCGACA GACAATCCCAGAAACACGCATAATACATTTCCGTCCAGCCCGGGGCAGTCTGACTGTCGGTGCCCTCCC AGGAACGGGGAAGGCCTCCGTCTGTGTGAAAGGGCACAGCACATCCCAGGTGCACCCTCCCCAAGTACT CCCACCCCGCCTACTGTCCATGCGGCCTCACTGGGGGCCATCAGCCTCACCAGCAAAGCAGAGATGAGA GCGTGGGAACTGTGTTCTTTCCTCCCTGCCCTCTACTGATTTCAGCCCAGCCCCTGCCTAGATCCTAGG TCCCTTTTCCTCCCGAGTTTGGCTGGCACGAGAGCTAGCCCAGCACATGAAGCAGGTGATGTTAAGTCA CAAGGTGCTGCTTTTCAGATCCACTATGCAAGAGGGGAGGGTGGGGCCACGTGAAAGGCAGCTCTAGAC ATCAACCAGTCCTGGGGGAGGGGAGTGGGAACCGGGCACAACTAGGAACAATGCCACCATTCCCACAGG AGTGGTACTTAAACCAGACAGCAGGGTTCAGAGGTGGCACACCGGGACAAAGCTGAGGCCCTGCACCTC AACAGCTGACTGCCAGGTGCCTGTGGGTGAACTGAGGGGAGTAGAGGGAGAGGGCAGGTGGAACTGGGG CAGAATCTAGTCATGCCCTAAAGCTAGTCCTGTAAACAATGGTGCCCCAGAAAGCTGCAGGTGGTGTTT GGAGAAGCAGTTACTTTTCAGTTACAAGACCCATCTCCCTAGTCTCAGCCTTACAACACCACGGGACTA AGGAAGAGCACTTCCTTGCCTCCGTAAGGCCAGAGGAAGAACCATCCCAATCATTTGATCTCCAGCTCC ACAGTAGAGAGAAACCTACAAAATGTCAAACCAGCTTCCCGACTCCCAGGAGCTCAAGCCAAGCCCAGA GGCAGTGGCTGGGGTCCCTGCAGGTCATGAGGGGCCTATGCCTTTACTCCTTTTAAACACCAGCACCCG TCTTTTCCCCAACCTAAAACCAACCACCAGCATTTCACTACAGGACCAAATGGAAACCGAGGGAACCCT GGGTCTTGGGAAGAACAACAGGAAACCAAGGTCTGACCTAGGGTTCCCTCCCAGTCTTCACATCACTCT GGCCTCATCACCAAGGTGACAGAGGACACAGGGGAGGGGGAAAACCCACACACACTCCTTGGAATGGGT CCTGTTATTTATGCTTGCTGCACAGACATATTAGAAGAAAAAAAAAAGCTTTGTATTATTCTTCCACAT ATGCTGGCTGCTGTTTACACACCCTGCCAATGCCTTAGCACTGGAGAGCTTTTTGCAATATGCTGGGGA AAGGGGAGGGAGGGAATGAAAGTGCCAAAGAAAACATGTTTTTAAGAACTCGGGTTTTATACAATAGAA TGTTTTCTAGCAGATGCCTCTTGTTTTAATATATTAAAATTTTGCAAAGCCCTTTGAGCTACTGCCTTA GTCTACCCACTGTCCTTTTGTTATGAGGTAGAGGATCTCATGACACCATACACACAAACCCATCATTGC CTGTGAATGCACGTAGGGCCAGAATTCCCCAGTTCCCGCTCCTCTGAGGGTTGATACTGCTGGGAATGC CAACCACTCCACAAGCAGAGGGAAGCCCCCTCAGGCCTGCAGGAGGAGCCGCAGCAGTGTGTCCAATTC AAACCAGCAGCAAAGAGCCTGACATTTTCCCATCCATCTATGAGGAAAGCCATCTCACAGAACATGGAC ATAGGCAACTTGCTCTCCCACACCAAGGGATGGGAATCTCTCCTACCTATAGTCATCCCTGCACTCCT ACGCGTAAGCGGCCGCGGCATCTAGATTCGAAGAAAATGACCGACCAAGCGACGCCCAACCTGCCATCA CGAGATTTCGATTCCACCGCCGCCTTCTATGAAAGG
Restriction Sites	SgfI-MluI
OTI Disclaimer	Our molecular clone sequence data has been matched to the sequence identifier above as a point of reference. Note that the complete sequence of this clone is largely the same as the reference sequence but may contain minor differences , e.g., single nucleotide polymorphisms (SNPs).
Reference Data
RefSeq	NM_032777.10
Synonyms	GPR124; TEM5
Summary	Endothelial receptor which functions together with RECK to enable brain endothelial cells to selectively respond to Wnt7 signals (WNT7A or WNT7B) (PubMed:28289266, PubMed:30026314). Plays a key role in Wnt7-specific responses, such as endothelial cell sprouting and migration in the forebrain and neural tube, and establishment of the blood-brain barrier (By similarity). Acts as a Wnt7-specific coactivator of canonical Wnt signaling: required to deliver RECK-bound Wnt7 to frizzled by assembling a higher-order RECK-ADGRA2-Fzd-LRP5-LRP6 complex (PubMed:30026314). ADGRA2-tethering function does not rely on its G-protein coupled receptor (GPCR) structure but instead on its combined capacity to interact with RECK extracellularly and recruit the Dishevelled scaffolding protein intracellularly (PubMed:30026314). Binds to the glycosaminoglycans heparin, heparin sulfate, chondroitin sulfate and dermatan sulfate (PubMed:16982628).[UniProtKB/Swiss-Prot Function]
Locus ID	25960
MW	72.1

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