Myelin Basic Protein (MBP) (NM_001025101) Human 3' UTR Clone

Specifications

Product Data
Product Name	Myelin Basic Protein (MBP) (NM_001025101) Human 3' UTR Clone
Vector	pMirTarget
ACCN	NM_001025101
Insert Size	1624 bp
Sequence Data	Insert Sequence (showhide) >SC215634 3’UTR clone of NM_001025101 The sequence shown below is from the reference sequence of NM_001025101. The complete sequence of this clone may contain minor differences, such as SNPs. Blue=Stop Codon Red=Cloning site GGCAAGTTGGACGCCCGCAAGATCCGCGAGATTCTCATTAAGGCCAAGAAGGGCGGAAAGATCGCCGTG TAACAATTGGCAGAGCTCAGAATTCAAGCGATCGCC CGCTCTGGATCACCCATGGCTAGACGCTGAAAACCCACCTGGTTCCGGAATCCTGTCCTCAGCTTCTTA ATATAACTGCCTTAAAACTTTAATCCCACTTGCCCCTGTTACCTAATTAGAGCAGATGACCCCTCCCCT AATGCCTGCGGAGTTGTGCACGTAGTAGGGTCAGGCCACGGCAGCCTACCGGCAATTTCCGGCCAACAG TTAAATGAGAACATGAAAACAGAAAACGGTTAAAACTGTCCCTTTCTGTGTGAAGATCACGTTCCTTCC CCCGCAATGTGCCCCCAGACGCACGTGGGTCTTCAGGGGGCCAGGTGCACAGACGTCCCTCCACGTTCA CCCCTCCACCCTTGGACTTTCTTTTCGCCGTGGCTGCGGCACCCTTGCGCTTTTGCTGGTCACTGCCAT GGAGGCACACAGCTGCAGAGACAGAGAGGACGTGGGCGGCAGAGAGGACTGTTGACATCCAAGCTTCCT TTGTTTTTTTTTCCTGTCCTTCTCTCACCTCCTAAAGTAGACTTCATTTTTCCTAACAGGATTAGACAG TCAAGGAGTGGCTTACTACATGTGGGAGCTTTTGGTATGTGACATGCGGGCTGGGCAGCTGTTAGAGTC CAACGTGGGGCAGCACAGAGAGGGGGCCACCTCCCCAGGCCGTGGCTGCCCACACACCCCAATTAGCTG AATTCGCGTGTGGCAGAGGGAGGAAAAGGAGGCAAACGTGGGCTGGGCAATGGCCTCACATAGGAAACA GGGTCTTCCTGGAGATTTGGTGATGGAGATGTCAAGCAGGTGGCCTCTGGACGTCACCGTTGCCCTGCA TGGTGGCCCCAGAGCAGCCTCTATGAACAACCTCGTTTCCAAACCACAGCCCACAGCCGGAGAGTCCAG GAAGACTTGCGCACTCAGAGCAGAAGGGTAGGAGTCCTCTAGACAGCCTCGCAGCCGCGCCAGTCGCCC ATAGACACTGGCTGTGACCGGGCGTGCTGGCAGCGGCAGTGCACAGTGGCCAGCACTAACCCTCCCTGA GAAGATAACCGGCTCATTCACTTCCTCCCAGAAGACGCGTGGTAGCGAGTAGGCACAGGCGTGCACCTG CTCCCGAATTACTCACCGAGACACACGGGCTGAGCAGACGGCCCCGTGGATGGAGACAAAGAGCTCTTC TGACCATATCCTTCTTAACACCCGCTGGCATCTCCTTTCGCGCCTCCCTCCCTAACCTACTGACCCACC TTTTGATTTTAGCGCACCTGTGATTGATAGGCCTTCCAAAGAGTCCCACGCTGGCATCACCCTCCCCGA GGACGGAGATGAGGAGTAGTCAGCGTGATGCCAAAACGCGTCTTCTTAATCCAATTCTAATTCTGAATG TTTCGTGTGGGCTTAATACCATGTCTATTAATATATAGCCTCGATGATGAGAGAGTTACAAAGAACAAA ACTCCAGACACAAACCTCCAAATTTTTCAGCAGAAGCACTCTGCGTCGCTGAGCTGAGGTCGGCTCTGC GATCCATACGTGGCCGCACCCACACAGCACGTGCTGTGACGATGGCTGAACGGAAAGTGTACACTGTTC CTGAATATTGAAATAAAACAATAAACTTTTAATGGTA AGCGGACCGACTTACGCGTAAGCGGCCGCGGCATCTAGATTCGAAGAAAATGACCGACCAAGCGACGCC CAACCTGCCATCACGAGATTTCGATTCCACCGCCGC
Restriction Sites	SgfI-RsrII
OTI Disclaimer	Our molecular clone sequence data has been matched to the sequence identifier above as a point of reference. Note that the complete sequence of this clone is largely the same as the reference sequence but may contain minor differences , e.g., single nucleotide polymorphisms (SNPs).
Reference Data
RefSeq	NM_001025101.2
Summary	The protein encoded by the classic MBP gene is a major constituent of the myelin sheath of oligodendrocytes and Schwann cells in the nervous system. However, MBP-related transcripts are also present in the bone marrow and the immune system. These mRNAs arise from the long MBP gene (otherwise called "Golli-MBP") that contains 3 additional exons located upstream of the classic MBP exons. Alternative splicing from the Golli and the MBP transcription start sites gives rise to 2 sets of MBP-related transcripts and gene products. The Golli mRNAs contain 3 exons unique to Golli-MBP, spliced in-frame to 1 or more MBP exons. They encode hybrid proteins that have N-terminal Golli aa sequence linked to MBP aa sequence. The second family of transcripts contain only MBP exons and produce the well characterized myelin basic proteins. This complex gene structure is conserved among species suggesting that the MBP transcription unit is an integral part of the Golli transcription unit and that this arrangement is important for the function and/or regulation of these genes. [provided by RefSeq, Jul 2008]
Locus ID	4155
MW	60.6

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