PNRC2 (NM_017761) Human 3' UTR Clone

Specifications

Product Data
Product Name	PNRC2 (NM_017761) Human 3' UTR Clone
Vector	pMirTarget
ACCN	NM_017761
Insert Size	1615 bp
Sequence Data	Insert Sequence (showhide) >SC215521 3’UTR clone of NM_017761 The sequence shown below is from the reference sequence of NM_017761. The complete sequence of this clone may contain minor differences, such as SNPs. Blue=Stop Codon Red=Cloning site GGCAAGTTGGACGCCCGCAAGATCCGCGAGATTCTCATTAAGGCCAAGAAGGGCGGAAAGATCGCCGTG TAACAATTGGCAGAGCTCAGAATTCAAGCGATCGCC CTTAAAACCTTACTTAAAGTACAGGTATAAAATAAGACAAATGTTTAAATTTAGTTATGTTCACGGATA GTTGTCAATTGGTCTGAAACAAATTCGCTAGGGAATCTATTTGTGTAGAACTAATTAATGTAAAAAAAA TAGACCATCTCGTGTTGTGTGCACTGTGATATAATGGTAGTATCAGTGCAACTTAAACTAATGATTGTA CTTGATATTAAGTGTTCTCAACTGAGTAACTTTTAAGTGGAAACCAAGTTTAGATTTGGGGAGTGGTAA AGGAATCAGCTTTTTCTATTGTTAGGGGAAGACAGTAATTTATCATTCATGGACCAGTAGATTGTTGAA AGTTGGTGAATCGGATTATAAGCTTCTAGCTAACACAAGGATTCAGAATTAGGTAAACATCTGAAGGTT TAGTATATTAGAAACACCCAAACCAGTAATATGCTAACCTGATGCACTGCTGAAAGAAAATGTGAATTT TTCGTAATAATTGCATTTTAGTGAATTGTACAGTGGGTGGAAAGGGCATTTGGAGCTCATTAGAATGAG ACATAGTACACCCCAATGGCCCTGTTTATTAAATGTAGTGGATTAAGTGTCTGTCAACAAATACACCAA AACCATTTTTTATAGAAACAGTATTTAATGGTCACTCAATAGCTTTCAAAATACATTTTTGTATTACAG CACTGCACAAGCTATTCTAATAGTGCTCTGGCCTCATCATTCCTGCAAAGCTTGCTTTGGGGAGTTGGA TAATGTGAAAATTTTAAGTACCTAGGGGAGAAAGAGCCATGTAAATATCTGTAATAAACTTGTAGCATA TGTAAAGTTTTCTTGGCCTTTATCTTACAAAAATGGAGTATTTTAGTATGAATTTGCTGAATGTAAGAC CGTGGACTGTTTTTTATAATATGGCCTAATTTTAAAGGTCCAAAATAACTTGTTTTTAAAGTTTGCCCT TGTGCTAAAGTGCCAGTGTATGTATGTTATACTTGATTTGGTTGTAAACTATATTTCAAAGTAAACCCT AGTGTAATAAGTTTTATAACTAAAAAGGTTTAAGCTGCTAAAACTATTTTTAAGAGATGTGAAATGCAG TATGGGACTATCTTTTTTTCCTCCTCTAAGCCCAAAGATTAACTAGAGTCCCTCCAACCTTATAGATTG TTGGCTTTCACAATCTTATAACCTAGGATACAGGTAGTTTCGAGTATGGTGCCAGTGATGTTTTGTTTT TGTTTGGTCAAGGGGTAGGTGCAACCCAATGGACCACTTATGCAAAAGATGTAAACTCTTGCATAATAC ATTGATAACATGTTTTGCCAACTTTAAATGCTTAAACATAAGCGAAACCAGTAGCAAGTATGTGGGTCA GCTTAAAAATTTTGATTGTTAATGCCCTATTTTCTAATTTGGCACCTCTTGATGCCTAAGCAGGTAAGC AGATGCCTAAGCTGTATTTCTCCAAATAAATCAAGATGAAGTACTGCCCAAGTTAAATATTGATAGCCT AAAGACAAGTTTATGTAGTACTTAATGTACATGATATGAATGTGAAGCATAAAATTAAATAAAATTTTT CCCCATTGGCTTGGTTTTATTTTAAAAA ACGCGTAAGCGGCCGCGGCATCTAGATTCGAAGAAAATGACCGACCAAGCGACGCCCAACCTGCCATCA CGAGATTTCGATTCCACCGCCGCCTTCTATGAAAGG
Restriction Sites	SgfI-MluI
OTI Disclaimer	Our molecular clone sequence data has been matched to the sequence identifier above as a point of reference. Note that the complete sequence of this clone is largely the same as the reference sequence but may contain minor differences , e.g., single nucleotide polymorphisms (SNPs).
Reference Data
RefSeq	NM_017761.4
Summary	Involved in nonsense-mediated mRNA decay (NMD) by acting as a bridge between the mRNA decapping complex and the NMD machinery (PubMed:19150429). May act by targeting the NMD machinery to the P-body and recruiting the decapping machinery to aberrant mRNAs (PubMed:19150429). Required for UPF1/RENT1 localization to the P-body (PubMed:19150429). Plays a role in glucocorticoid receptor-mediated mRNA degradation by interacting with the glucocorticoid receptor NR3C1 in a ligand-dependent manner when it is bound to the 5' UTR of target mRNAs and recruiting the RNA helicase UPF1 and the mRNA-decapping enzyme DCP1A, leading to RNA decay (PubMed:25775514). Also acts as a nuclear receptor coactivator (PubMed:11574675). May play a role in controlling the energy balance between energy storage and energy expenditure (By similarity).[UniProtKB/Swiss-Prot Function]
Locus ID	55629
MW	62.3

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