Arg 3.1 (ARC) (NM_015193) Human 3' UTR Clone

Specifications

Product Data
Product Name	Arg 3.1 (ARC) (NM_015193) Human 3' UTR Clone
Vector	pMirTarget
Synonyms	Arg3.1; hArc
ACCN	NM_015193
Insert Size	1581 bp
Sequence Data	Insert Sequence (showhide) >SC215504 3’UTR clone of NM_015193 The sequence shown below is from the reference sequence of NM_015193. The complete sequence of this clone may contain minor differences, such as SNPs. Blue=Stop Codon Red=Cloning site GGCAAGTTGGACGCCCGCAAGATCCGCGAGATTCTCATTAAGGCCAAGAAGGGCGGAAAGATCGCCGTG TAACAATTGGCAGAGCTCAGAATTCAAGCGATCGCC GTGGCCAGTGACCGGACCCAGCCCGAGTAGAGGGCATCCCGGAGCCCCCAGCCTGCCCACTACATCCAG CCTGTGGCTTTGCCCACCAGGACTTTTGAGCTGGGGCTGACTCCTGCAGGGGAAGCCCTGGTCCAGCTG GGTGCCCCCTCGAGCTCCGGGCGGACTCGCACACACTCGTGTCATCCAGATGTGAGCACCGCACCCAGC GGCAAAGAGCCCTCCCCCCTGCAGGGCTCCACCCATCACCCTCCCTCCGTCTGTCTTTCCGGCCTGGAC CCCACCCTCCACACTCTCAGGCCATCACAGAACACCCCAGCTTCCTCATTCTGCTACAACACCCAGGCC CTCTGGACATCCAGAAAACCAAGTGTCCGGATGGCAGGGGCCAGCGGCCACCAAGCTCATGGGACACCC AGAGCAGAAGCTAGGGCAGAGCCAATGCTGAGGGAGCCTCGACTTCCGGCGCCGCCGCCCTCTCCCGGC ATCCGCAGAGCCAGCTGACGCCCTCCCTGCCTCCCAGGGCAGCTGGCCAGCCTCGGGCAGCGCGGCCCC CTCCTCCCAGGGGAGAGTAGAAGTCGCACACGCAGCAGAGCAGACCTGATGTCCCGGTGCTTCCTGGCC CCTCAGCTCCAGTGATTCACGCCCGCCTGGAGAAGAATCAGAGCTCAGCTCATGACTCACCCATGGCAG GCGGAGGGTCCCAGAGGGGCTGAGTCCTCAAATCCGGCTGAGGCAGCAGCTGGCACCATCAGAGCCAGG AGAGTGACAACAGGTCTCAAGGTTCCCACAAAGTCTTTGCTGCTGTGCTGGGCACCACCCACCCCTCAC CTTGCAGGCTGCCTGCGTGGGAGGCGAAGTCCCAGGACAGCCCAGAGGGGGGCTACAGAGAGGAGTCGG CTGCAGCAGAGGGCAGGAGCCCCAGCTTAGCCCTGAGCGCCAGCGCGAGGACCAGGGCCTGCCACTAAG CCCGCCCCGCTGGCCGCCAGCTGCCCGTCCCCAGAGCCACTGCAGCAGGAGTCGGGCCCTGCCTCCCTC CCAGCAGGGAAACCCCGCCCGCTGCCAGGCCATCCTCTCTGCCAGAGGCTTTCATGAGCCCCAAGGCTG GGGCCACAGCTCCTACCCCTGCCCAGCAGCCCTGAGCTCAGCTGCAGGAAGGACATCCCAGAAGCCATG GCTCCTGGGGCGCTTCCAGGCATTCTGCCCTGCCCCGACACCAGAACCCTGGTGCTGGTGGGCCACTAG CGTCTGCAGCCTAAGCAGGTGCTGGCTCAGGGTTCATCGTTCTGCCTTGTCCACTGGGGGACCAGCCCT GCAGACCACTCTGACAAGTCTTCAGCCCACACCCTGCCAGCCCCACAGATTTTATTTTTGCACATAAGC CATAACCAATCCTCAAGGCTGGCACAGGCTTTGGGGAAGCCCTGGAGCCTGTGAAGACCCTGGAAACCT CATGAGGCTGTGGCCAACCCCTGCCCCTTGCCCCACACAGACCAGGCCTTAAATGTCGGTCCAGGCCCT GTGCACCTTACCCCAGAGACAGACTCTTTTTGTAAGATTTTGTTAATAAAACACTGAAACTTC ACGCGTAAGCGGCCGCGGCATCTAGATTCGAAGAAAATGACCGACCAAGCGACGCCCAACCTGCCATCA CGAGATTTCGATTCCACCGCCGCCTTCTATGAAAGG
Restriction Sites	SgfI-MluI
OTI Disclaimer	Our molecular clone sequence data has been matched to the sequence identifier above as a point of reference. Note that the complete sequence of this clone is largely the same as the reference sequence but may contain minor differences , e.g., single nucleotide polymorphisms (SNPs).
Reference Data
RefSeq	NM_015193.5
Synonyms	Arg3.1; hArc
Summary	Master regulator of synaptic plasticity that self-assembles into virion-like capsids that encapsulate RNAs and mediate intercellular RNA transfer in the nervous system. ARC protein is released from neurons in extracellular vesicles that mediate the transfer of ARC mRNA into new target cells, where ARC mRNA can undergo activity-dependent translation. ARC capsids are endocytosed and are able to transfer ARC mRNA into the cytoplasm of neurons. Acts as a key regulator of synaptic plasticity: required for protein synthesis-dependent forms of long-term potentiation (LTP) and depression (LTD) and for the formation of long-term memory. Regulates synaptic plasticity by promoting endocytosis of AMPA receptors (AMPARs) in response to synaptic activity: this endocytic pathway maintains levels of surface AMPARs in response to chronic changes in neuronal activity through synaptic scaling, thereby contributing to neuronal homeostasis. Acts as a postsynaptic mediator of activity-dependent synapse elimination in the developing cerebellum by mediating elimination of surplus climbing fiber synapses. Accumulates at weaker synapses, probably to prevent their undesired enhancement. This suggests that ARC-containing virion-like capsids may be required to eliminate synaptic material. Required to transduce experience into long-lasting changes in visual cortex plasticity and for long-term memory (By similarity). Involved in postsynaptic trafficking and processing of amyloid-beta A4 (APP) via interaction with PSEN1 (By similarity). In addition to its role in synapses, also involved in the regulation of the immune system: specifically expressed in skin-migratory dendritic cells and regulates fast dendritic cell migration, thereby regulating T-cell activation (By similarity).[UniProtKB/Swiss-Prot Function]
Locus ID	23237
MW	56.3

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