HMBOX1 (NM_001135726) Human 3' UTR Clone

Specifications

Product Data
Product Name	HMBOX1 (NM_001135726) Human 3' UTR Clone
Vector	pMirTarget
Synonyms	HNF1LA; HOT1; PBHNF; TAH1
ACCN	NM_001135726
Insert Size	2000 bp
Sequence Data	Insert Sequence (showhide) >SC215368 3’UTR clone of NM_001135726 The sequence shown below is from the reference sequence of NM_001135726. The complete sequence of this clone may contain minor differences, such as SNPs. Blue=Stop Codon Red=Cloning site GGCAAGTTGGACGCCCGCAAGATCCGCGAGATTCTCATTAAGGCCAAGAAGGGCGGAAAGATCGCCGTG TAACAATTGGCAGAGCTCAGAATTCAAGCGATCGCC ATCAAGACAGAGGCCCTGGATGATGACTGATCAGGGAGGTTAAACATGACAAGTTAACTTAGTTTAGAC GTAGCACCTTAGCAGACTTTCCTCGGTCCTTAACATGTGTTCTTACAGTATAACTTGCAGTTTCTTGTA TGTCAGGTAGCTGTTAGGGTCTTGTTCTGTGAAGATGGCATGGTGCCCTCAGCCTTTGCATATACTCTC TCAGTATTAACTCCCAGTAAATAATAACCAACCAACCAACCAAACTTCCCTCTCCCAGCCCCCGAGGCT AGAAAATCTTGCTGCTCCGTCTTAGCATTCCAAGAAAGTGCTTCCAGGTATTTAGATAGCCCTCAGTTC TCAAATATTAGACTACGTGTAAAATCTTGGGTACCTTTAGATTCTTGTAACACTAGTCTGTACTCCCTT TTCCTTCCCCAAGACTGATAGGATGCAAGCTGAGGTCGTGGCACAGGAATGACAGACACCATTTGGGGA GTATCCACAGAGTCAAAGGAACACTAGAATCCCCACCTCAGCGTGAGGATAATTGATTTCCAGCTGCAA TAAGCCGTGCCTCATTATAGCCACACTGTGGCTAGATTATACTTCTTTGGGTGCTGTGCTAAGAATGTC AATGGAAAAAGCCGATCTCAGATTTTGTTTGAAGTTAACATGCCTGACACAGACATCCTTTCCTCTCAC AAGCTGTGTGACTTAGTAGATAAAATACTGCCTTCTGCCTTTGGGACCATGATTAAAAACAAAGACAAA AACCAAAAGTCATTAAAAAAAAAAAAAAAAAAAACCCAGCTTGAGAGCATTGGAAAAAAAAAATATGAG CTGAATGTCTAATGGATGCTAAGTCCAGTTTTCAGAACCACTGTACATTCCACGGCACAGTTAGCAGTG CCTGCCTGGAAAAGTTTTGGAGGTCATCGTGGAAGTTGCTTTGCCTCCTGTCAGTGTCCCCTTTCCCTG CTACCAAAAAAGTCTTTCAAGGATGGAGCTAAGGTCAAAAATGAGTGAAAAAACTTGCAGTGTTTGTAT CCATTAAACGGAAGCCCCCTCACTCTGAGAGGTCACTAGAGGACTTCATAGTGGGGTTGTGCTGCTTAT CACAGATGCAGACACTTGCCCAGATAGGAGCAGAGAAAAGCAGGGGACGTTTCCTACTCACATTGTGGC TGTATGAGAACACGATGGGACTGCTTTGCTGTTCTCTTTACTCTGTCCTTGGAGAGGTGTGAAAAGCTG TATTGCTACAGGCAATTTATTTAATAATTGGAAGCCATATTGATAATGGATGTGGTAATATTTGTAAAG TTTAATCTACTTTAAGCGGCAGTAACTAATGGAATTTTTTTCCTTGATCACATATGTAGCACTTTTGTT ACTTTTTAAAGATATTTATATTTGATAAATCTTTTTTTCATTTTGAGAACTCAAAATACCAAACAGTGA ACTTGCATTCTAAAGTCACCCTGTGATCACCTTGTCATCTAGTAGCAAAATGATGAACTATTCATGCAT CAAAGAAAATTACATCTGCTGGCCTTGTATGAAAATGATCTCTTGGCATCCCGATTAAATGACACACTG TCACTGTGGGTAAGAGGAAAGAGCCTTCAATGTAGCAGCACAGGGTGCGCCTGAAAGAGGCACAACTGC TGTGGATTTTCTGCCTCGCTCCATCTCTCCTATGTATAATGAAGCCTTGTTTAAAGGGGCATGTGGGGC TGGATGTTAAGCACGGCTTCTTTTTGTCCGTTACCTGAAAACAATTTCTAAGATAAAAGGAAGGTGCCA TTTCCTTACCTCTTCACCCATCCTCCTCCACCAAATGTATTCAACTTAAAACTGTGAGAGAGAGAGACT GAATGACCTTCCTCAGTTTTCCCTTTCTCATTCAGGAGATACTGAATATCCGCCAGTTTGTAGTTGGTT TCCTTCCACTTAAGGCACACGCTGACTGCATCATTTCCTTATCTGTTAATCCTGCTTATGTGAGTGTG ACGCGTAAGCGGCCGCGGCATCTAGATTCGAAGAAAATGACCGACCAAGCGACGCCCAACCTGCCATCA CGAGATTTCGATTCCACCGCCGCCTTCTATGAAAGG
Restriction Sites	SgfI-MluI
OTI Disclaimer	Our molecular clone sequence data has been matched to the sequence identifier above as a point of reference. Note that the complete sequence of this clone is largely the same as the reference sequence but may contain minor differences , e.g., single nucleotide polymorphisms (SNPs).
Reference Data
RefSeq	NM_001135726.3
Synonyms	HNF1LA; HOT1; PBHNF; TAH1
Summary	Binds directly to 5'-TTAGGG-3' repeats in telomeric DNA (PubMed:23813958, PubMed:23685356). Associates with the telomerase complex at sites of active telomere processing and positively regulates telomere elongation (PubMed:23685356). Important for TERT binding to chromatin, indicating a role in recruitment of the telomerase complex to telomeres (By similarity). Also plays a role in the alternative lengthening of telomeres (ALT) pathway in telomerase-negative cells where it promotes formation and/or maintenance of ALT-associated promyelocytic leukemia bodies (APBs) (PubMed:23813958). Enhances formation of telomere C-circles in ALT cells, suggesting a possible role in telomere recombination (PubMed:23813958). Might also be involved in the DNA damage response at telomeres (PubMed:23813958).[UniProtKB/Swiss-Prot Function]
Locus ID	79618
MW	75.9

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