Axin 2 (AXIN2) (NM_004655) Human 3' UTR Clone

Specifications

Product Data
Product Name	Axin 2 (AXIN2) (NM_004655) Human 3' UTR Clone
Vector	pMirTarget
Synonyms	AXIL; ODCRCS
ACCN	NM_004655
Insert Size	1443 bp
Sequence Data	Insert Sequence (showhide) >SC214484 3’UTR clone of NM_004655 The sequence shown below is from the reference sequence of NM_004655. The complete sequence of this clone may contain minor differences, such as SNPs. Blue=Stop Codon Red=Cloning site GGCAAGTTGGACGCCCGCAAGATCCGCGAGATTCTCATTAAGGCCAAGAAGGGCGGAAAGATCGCCGTG TAACAATTGGCAGAGCTCAGAATTCAAGCGATCGCC ATTCTGGGCAAAGTGGAGCGGATCGATTGAGCCCTGGGGTCTGGCTTTGGTGAACTGTTGGAGCCCGAA GCTCTTGTGAACTGTCTTGGCTGTGAGCAACTGCGACAAAACATTTTGAAGGAAAATTAAACCAATGAA GAAGACAAAGTCTAAGGAAGAATCGGCCAGTGGGCCTTCGGGAGGGCGGGGGGAGGTTGATTTTCATGA TTCATGAGCTGGGTACTGACTGAGATAAGAAAAGCCTGAACTATTTATTAAAAACATGACCACTCTTGG CTATTGAAGATGCTGCCTGTATTTGAGAGACTGCCATACATAATATATGACTTCCTAGGGATCTGAAAT CCATAAACTAAGAGAAACTGTGTATAGCTTACCTGAACAGGAATCCTTACTGATATTTATAGAACAGTT GATTTCCCCCATCCCCAGTTTATGGATATGCTGCTTTAAACTTGGAAGGGGGAGACAGGAAGTTTTAAT TGTTCTGACTAAACTTAGGAGTTGAGCTAGGAGTGCGTTCATGGTTTCTTCACTAACAGAGGAATTATG CTTTGCACTACGTCCCTCCAAGTGAAGACAGACTGTTTTAGACAGACTTTTTAAAATGGTGCCCTACCA TTGACACATGCAGAAATTGGTGCGTTTTGTTTTTTTTTTTCCTATGCTGCTCTGTTTTGTCTTAAAGGT CTTGAGGGTTGACCATGTTGCGTCATCATCAACATTTTGGGGGTTGTGTTGGATGGGATGATCTGTTGC AGAGGGAGAGGCAGGGAACCCTGCTCCTTCGGGCCCCAGGTTGATCCTGTGACTGAGGCTCCCCCTCAT GTAGCCTCCCCAGGCCCAGGGCCCTGAGGCCTGCTAGAATCACTGCCGCTGTGCTTTCGTGGAAATGAC AGTTCCTTGTTTTTTTTGTTTCTGTTTTTGTTTTACATTAGTCATTGGACCACAGCCATTCAGGAACTA CCCCCTGCCCCACAAAGAAATGAACAGTTGTAGGGAGACCCAGCAGCACCTTTCCTCCACACACCTTCA TTTTGATGTTCGGGTTTTTGTGTTAAGTTAATCTGTACATTCTGTTTGCCATTGTTACTTGTACTATAC ATCTGTATATAGTGTACGGCAAAAGAGTATTAATCCACTATCTCTAGTGCTTGACTTTAAATCAGTACA GTACCTGTACCTGCACGGTCACCCGCTCCGTGTGTCGCCCTATATTGAGGGCTCAAGCTTTCCCTTGTT TTTTGAAAGGGGTTTATGTATAAATATATTTTATGCCTTTTTATTACAAGTCTTGTACTCAATGACTTT TGTCATGACATTTTGTTCTACTTATACTGTAAATTATGCATTATAAAGAGTTCATTTAAGGAAAATTAC TTGGTACAATAATTATTGTAATTAAGAGATGTAGCCTTTATTAAAATTTTATATTTTTCAAAA ACGCGTAAGCGGCCGCGGCATCTAGATTCGAAGAAAATGACCGACCAAGCGACGCCCAACCTGCCATCA CGAGATTTCGATTCCACCGCCGCCTTCTATGAAAGG
Restriction Sites	SgfI-MluI
OTI Disclaimer	Our molecular clone sequence data has been matched to the sequence identifier above as a point of reference. Note that the complete sequence of this clone is largely the same as the reference sequence but may contain minor differences , e.g., single nucleotide polymorphisms (SNPs).
Reference Data
RefSeq	NM_004655.4
Synonyms	AXIL; ODCRCS
Summary	The Axin-related protein, Axin2, presumably plays an important role in the regulation of the stability of beta-catenin in the Wnt signaling pathway, like its rodent homologs, mouse conductin/rat axil. In mouse, conductin organizes a multiprotein complex of APC (adenomatous polyposis of the colon), beta-catenin, glycogen synthase kinase 3-beta, and conductin, which leads to the degradation of beta-catenin. Apparently, the deregulation of beta-catenin is an important event in the genesis of a number of malignancies. The AXIN2 gene has been mapped to 17q23-q24, a region that shows frequent loss of heterozygosity in breast cancer, neuroblastoma, and other tumors. Mutations in this gene have been associated with colorectal cancer with defective mismatch repair. [provided by RefSeq, Jul 2008]
Locus ID	8313
MW	54

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