Rab5 (RAB5A) (NM_004162) Human 3' UTR Clone

Specifications

Product Data
Product Name	Rab5 (RAB5A) (NM_004162) Human 3' UTR Clone
Vector	pMirTarget
Synonyms	RAB5
ACCN	NM_004162
Insert Size	1382 bp
Sequence Data	Insert Sequence (showhide) >SC214172 3’UTR clone of NM_004162 The sequence shown below is from the reference sequence of NM_004162. The complete sequence of this clone may contain minor differences, such as SNPs. Blue=Stop Codon Red=Cloning site GGCAAGTTGGACGCCCGCAAGATCCGCGAGATTCTCATTAAGGCCAAGAAGGGCGGAAAGATCGCCGTG TAACAATTGGCAGAGCTCAGAATTCAAGCGATCGCC CCAACCAGGAATCAGTGTTGTAGTAACTAAACCTCTAGTTTGAACTAGCTGGAATAGTCTTCTGCTTCC TAAATGTTAATAACAATGGAATTGGAGCATTTAACCAGCCCAGTATGACTTCCAAAAGAAGAGACTTAT GATAGAGTCAAGTTTCTAATACAGAATTATTTTAAGTGTTTTGAACTTAATTTTTAATAACATGCATGG GTCCCTCTCACTAATGTTTCAACAATAGGGAAAAATGAGAACTATGTGGACACTTGTTTCATTGGAAGG TTAGGGGGAATAATTTCTCATCACTAGGAATATAGACAAATGACTGTCTGGGCCCACACAGTTAACCAG CCCATTTCTCCACACTGGTACAGTAGTCACCTGTGAAAAAAAAATTGGAACTTACTAATTTGGGCTTTT CAAAAACATTCTTTGTTTAGAAGGAGATTCTAAAGTTATTTATGATGCTTAGCCATAGTATTCAGGCAA ATGTTCATTTCTCCTGGTACCTGTATTTAAAATGTACATTCCACATTTTAATAAATTAACCACAAGAAA ATAATCCCACATATACAAGGTCAGGGGTGGGGAAGAGTATTAATGGTATCTTAATTATACCCAGTCTGG TTTTTTTTTTTTAAATGGGGTAAAAATCAAATGCAACCCCATCTTGTTTTAGGAATTTTGAGAACTAAT AAATGCACCTTAATGGTCAGTGTTCCTTTCAAACATGTGAGTTCTTTAACAAAAATGAAATAAACCAGG TGTCTGTGATTTCTAATTAATCACCGCTGGCCATTACACAGGTTTTGTTGTTTGGGGTGGGGAGGGGGC TTTTGTTCCCTTTTGACATAATATAGTCAATGCACTAACAATTATGTATATTCAAACTTGATTATTTTA AATTCGATCTTCAGCTGTACTGTAAATAGGGTACTGCATTGTAGTCTCCATATCTGTATTACTTTTCTG TAATATTTAAGAGTTGCTTAAAAGCATACAAAATGTACTGTTACTAAAACAGCTAATTATTTCTCTCTC CCCCTTTGACAGGAAGGGGCTTCAGTTGTTCCTCCATGGCTAGAACCATAATAAACAATGTACCCGTAA TTTGTAACATAAAGTATTGCAATATGTTAGTAACAATCTTGCAGCCTTCCTTTCCAAAGTTCATTTTAT TTTGATCAGTTCAGTATATTGCACTAATTATTTTAGGTATTTTCATTATATGAAAGCTACCATGTGTCA GAGATGATTTAATCTATTTAAGTGTTGGACTGCTAGGAGAACTTGTACATTTATGATAATGCAGAATTA GGAAAACGGTTCACCAGTGTTTAGTTTTATATTGAGGTGCTCAGGTTGGAATAAAGTGGTATAAAAAGC AA ACGCGTAAGCGGCCGCGGCATCTAGATTCGAAGAAAATGACCGACCAAGCGACGCCCAACCTGCCATCA CGAGATTTCGATTCCACCGCCGCCTTCTATGAAAGG
Restriction Sites	SgfI-MluI
OTI Disclaimer	Our molecular clone sequence data has been matched to the sequence identifier above as a point of reference. Note that the complete sequence of this clone is largely the same as the reference sequence but may contain minor differences , e.g., single nucleotide polymorphisms (SNPs).
Reference Data
RefSeq	NM_004162.5
Synonyms	RAB5
Summary	The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different sets of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion. RAB5A is required for the fusion of plasma membranes and early endosomes (PubMed:10818110, PubMed:14617813, PubMed:16410077, PubMed:15378032). Contributes to the regulation of filopodia extension (PubMed:14978216). Required for the exosomal release of SDCBP, CD63, PDCD6IP and syndecan (PubMed:22660413). Regulates maturation of apoptotic cell-containing phagosomes, probably downstream of DYN2 and PIK3C3 (By similarity).[UniProtKB/Swiss-Prot Function]
Locus ID	5868
MW	53.6

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