SREBP1 (SREBF1) (NM_004176) Human 3' UTR Clone

Specifications

Product Data
Product Name	SREBP1 (SREBF1) (NM_004176) Human 3' UTR Clone
Vector	pMirTarget
Synonyms	bHLHd1; HMD; IFAP2; SREBP1
ACCN	NM_004176
Insert Size	1318 bp
Sequence Data	Insert Sequence (showhide) >SC213706 3’UTR clone of NM_004176 The sequence shown below is from the reference sequence of NM_004176. The complete sequence of this clone may contain minor differences, such as SNPs. Blue=Stop Codon Red=Cloning site GGCAAGTTGGACGCCCGCAAGATCCGCGAGATTCTCATTAAGGCCAAGAAGGGCGGAAAGATCGCCGTG TAACAATTGGCAGAGCTCAGAATTCAAGCGATCGCC GGCGGTGGGACCACTGTCACTTCCAGCTAGACCCCGTGTCCCCGGCCTCAGCACCCCTGTCTCTAGCCA CTTTGGTCCCGTGCAGCTTCTGTCCTGCGTCGAAGCTTTGAAGGCCGAAGGCAGTGCAAGAGACTCTGG CCTCCACAGTTCGACCTGCGGCTGCTGTGTGCCTTCGCGGTGGAAGGCCCGAGGGGCGCGATCTTGACC CTAAGACCGGCGGCCATGATGGTGCTGACCTCTGGTGGCCGATCGGGGCACTGCAGGGGCCGAGCCATT TTGGGGGGCCCCCCTCCTTGCTCTGCAGGCACCTTAGTGGCTTTTTTCCTCCTGTGTACAGGGAAGAGA GGGGTACATTTCCCTGTGCTGACGGAAGCCAACTTGGCTTTCCCGGACTGCAAGCAGGGCTCTGCCCCA GAGGCCTCTCTCTCCGTCGTGGGAGAGAGACGTGTACATAGTGTAGGTCAGCGTGCTTAGCCTCCTGAC CTGAGGCTCCTGTGCTACTTTGCCTTTTGCAAACTTTATTTTCATAGATTGAGAAGTTTTGTACAGAGA ATTAAAAATGAAATTATTTATAATCTGGGTTTTGTGTCTTCAGCTGATGGATGTGCTGACTAGTGAGAG TGCTTGGGCCCTCCCCCAGCACCTAGGGAAAGGCTTCCCCTCCCCCTCCGGCCACAAGGTACACAACTT TTAACTTAGCTCTTCCCGATGTTTGTTTGTTAGTGGGAGGAGTGGGGAGGGCTGGCTGTATGGCCTCCA GCCTACCTGTTCCCCCTGCTCCCAGGGCACATGGTTGGGCTGTGTCAACCCTTAGGGCCTCCATGGGGT CAGTTGTCCCTTCTCACCTCCCAGCTCTGTCCCCATCAGGTCCCTGGGTGGCACGGGAGGATGGACTGA CTTCCAGGACCTGTTGTGTGACAGGAGCTACAGCTTGGGTCTCCCTGCAAGAAGTCTGGCACGTCTCAC CTCCCCCATCCCGGCCCCTGGTCATCTCACAGCAAAGAAGCCTCCTCCCTCCCGACCTGCCGCCACACT GGAGAGGGGGCACAGGGGCGGGGGAGGTTTCCTGTTCTGTGAAAGGCCGACTCCCTGACTCCATTCATG CCCCCCCCCCCAGCCCCTCCCTTCATTCCCATTCCCCAACCTAAAGCCTGGCCCGGCTCCCAGCTGAAT CTGGTCGGAATCCACGGGCTGCAGATTTTCCAAAACAATCGTTGTATCTTTATTGACTTTTTTTTTTTT TTTTTTCTGAATGCAATGACTGTTTTTTACTCTTAAGGAAAATAAACATCTTTTAGAAACAGCTCGATA CACACAA ACGCGTAAGCGGCCGCGGCATCTAGATTCGAAGAAAATGACCGACCAAGCGACGCCCAACCTGCCATCA CGAGATTTCGATTCCACCGCCGCCTTCTATGAAAGG
Restriction Sites	SgfI-MluI
OTI Disclaimer	Our molecular clone sequence data has been matched to the sequence identifier above as a point of reference. Note that the complete sequence of this clone is largely the same as the reference sequence but may contain minor differences , e.g., single nucleotide polymorphisms (SNPs).
Reference Data
RefSeq	NM_004176.5
Synonyms	bHLHd1; HMD; IFAP2; SREBP1
Summary	This gene encodes a basic helix-loop-helix-leucine zipper (bHLH-Zip) transcription factor that binds to the sterol regulatory element-1 (SRE1), which is a motif that is found in the promoter of the low density lipoprotein receptor gene and other genes involved in sterol biosynthesis. The encoded protein is synthesized as a precursor that is initially attached to the nuclear membrane and endoplasmic reticulum. Following cleavage, the mature protein translocates to the nucleus and activates transcription. This cleaveage is inhibited by sterols. This gene is located within the Smith-Magenis syndrome region on chromosome 17. Alternative promoter usage and splicing result in multiple transcript variants, including SREBP-1a and SREBP-1c, which correspond to RefSeq transcript variants 2 and 3, respectively. [provided by RefSeq, Nov 2017]
Locus ID	6720
MW	48.2

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