Tissue Factor (F3) (NM_001993) Human 3' UTR Clone

Specifications

Product Data
Product Name	Tissue Factor (F3) (NM_001993) Human 3' UTR Clone
Vector	pMirTarget
Synonyms	CD142; TF; TFA
ACCN	NM_001993
Insert Size	1317 bp
Sequence Data	Insert Sequence (showhide) >SC213705 3’UTR clone of NM_001993 The sequence shown below is from the reference sequence of NM_001993. The complete sequence of this clone may contain minor differences, such as SNPs. Blue=Stop Codon Red=Cloning site GGCAAGTTGGACGCCCGCAAGATCCGCGAGATTCTCATTAAGGCCAAGAAGGGCGGAAAGATCGCCGTG TAACAATTGGCAGAGCTCAGAATTCAAGCGATCGCC AAGGAGAACTCCCCACTGAATGTTTCATAAAGGAAGCACTGTTGGAGCTACTGCAAATGCTATATTGCA CTGTGACCGAGAACTTTTAAGAGGATAGAATACATGGAAACGCAAATGAGTATTTCGGAGCATGAAGAC CCTGGAGTTCAAAAAACTCTTGATATGACCTGTTATTACCATTAGCATTCTGGTTTTGACATCAGCATT AGTCACTTTGAAATGTAACGAATGGTACTACAACCAATTCCAAGTTTTAATTTTTAACACCATGGCACC TTTTGCACATAACATGCTTTAGATTATATATTCCGCACTCAAGGAGTAACCAGGTCGTCCAAGCAAAAA CAAATGGGAAAATGTCTTAAAAAATCCTGGGTGGACTTTTGAAAAGCTTTTTTTTTTTTTTTTTTTTTT TTGAGACGGAGTCTTGCTCTGTTGCCCAGGCTGGAGTGCAGTAGCACGATCTCGGCTCACTGCACCCTC CGTCTCTCGGGTTCAAGCAATTGTCTGCCTCAGCCTCCCGAGTAGCTGGGATTACAGGTGCGCACTACC ACGCCAAGCTAATTTTTGTATTTTTTAGTAGAGATGGGGTTTCACCATCTTGGCCAGGCTGGTCTTGAA TTCCTGACCTCAGGTGATCCACCCACCTTGGCCTCCCAAAGTGCTAGTATTATGGGCGTGAACCACCAT GCCCAGCCGAAAAGCTTTTGAGGGGCTGACTTCAATCCATGTAGGAAAGTAAAATGGAAGGAAATTGGG TGCATTTCTAGGACTTTTCTAACATATGTCTATAATATAGTGTTTAGGTTCTTTTTTTTTTCAGGAATA CATTTGGAAATTCAAAACAATTGGCAAACTTTGTATTAATGTGTTAAGTGCAGGAGACATTGGTATTCT GGGCACCTTCCTAATATGCTTTACAATCTGCACTTTAACTGACTTAAGTGGCATTAAACATTTGAGAGC TAACTATATTTTTATAAGACTACTATACAAACTACAGAGTTTATGATTTAAGGTACTTAAAGCTTCTAT GGTTGACATTGTATATATAATTTTTTAAAAAGGTTTTCTATATGGGGATTTTCTATTTATGTAGGTAAT ATTGTTCTATTTGTATATATTGAGATAATTTATTTAATATACTTTAAATAAAGGTGACTGGGAATTGTT ACTGTTGTACTTATTCTATCTTCCATTTATTATTTATGTACAATTTGGTGTTTGTATTAGCTCTACTAC AGTAAATGACTGTAAAATTGTCAGTGGCTTACAACAACGTATCTTTTTCGCTTATAATACATTTTGGTG ACTGTA ACGCGTAAGCGGCCGCGGCATCTAGATTCGAAGAAAATGACCGACCAAGCGACGCCCAACCTGCCATCA CGAGATTTCGATTCCACCGCCGCCTTCTATGAAAGG
Restriction Sites	SgfI-MluI
OTI Disclaimer	Our molecular clone sequence data has been matched to the sequence identifier above as a point of reference. Note that the complete sequence of this clone is largely the same as the reference sequence but may contain minor differences , e.g., single nucleotide polymorphisms (SNPs).
Reference Data
RefSeq	NM_001993.5
Synonyms	CD142; TF; TFA
Summary	This gene encodes coagulation factor III which is a cell surface glycoprotein. This factor enables cells to initiate the blood coagulation cascades, and it functions as the high-affinity receptor for the coagulation factor VII. The resulting complex provides a catalytic event that is responsible for initiation of the coagulation protease cascades by specific limited proteolysis. Unlike the other cofactors of these protease cascades, which circulate as nonfunctional precursors, this factor is a potent initiator that is fully functional when expressed on cell surfaces, for example, on monocytes. There are 3 distinct domains of this factor: extracellular, transmembrane, and cytoplasmic. Platelets and monocytes have been shown to express this coagulation factor under procoagulatory and proinflammatory stimuli, and a major role in HIV-associated coagulopathy has been described. Platelet-dependent monocyte expression of coagulation factor III has been described to be associated with Coronavirus Disease 2019 (COVID-19) severity and mortality. This protein is the only one in the coagulation pathway for which a congenital deficiency has not been described. Alternate splicing results in multiple transcript variants.[provided by RefSeq, Aug 2020]
Locus ID	2152
MW	51.8

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