CD16 (FCGR3A) (NM_001127595) Human 3' UTR Clone

Specifications

Product Data
Product Name	CD16 (FCGR3A) (NM_001127595) Human 3' UTR Clone
Vector	pMirTarget
Synonyms	CD16; CD16A; FCG3; FCGR3; FCGRIII; FCR-10; FCRIII; FCRIIIA; IGFR3; IMD20
ACCN	NM_001127595
Insert Size	1283 bp
Sequence Data	Insert Sequence (showhide) >SC213694 3’UTR clone of NM_001127595 The sequence shown below is from the reference sequence of NM_001127595. The complete sequence of this clone may contain minor differences, such as SNPs. Blue=Stop Codon Red=Cloning site GGCAAGTTGGACGCCCGCAAGATCCGCGAGATTCTCATTAAGGCCAAGAAGGGCGGAAAGATCGCCGTG TAACAATTGGCAGAGCTCAGAATTCAAGCGATCGCC AAATGGAGAAAGGACCCTCAAGACAAATGACCCCCATCCCATGGGGGTAATAAGAGCAGTAGCAGCAGC ATCTCTGAACATTTCTCTGGATTTGCAACCCCATCATCCTCAGGCCTCTCTACAAGCAGCAGGAAACAT AGAACTCAGAGCCAGATCCCTTATCCAACTCTCGACTTTTCCTTGGTCTCCAGTGGAAGGGAAAAGCCC ATGATCTTCAAGCAGGGAAGCCCCAGTGAGTAGCTGCATTCCTAGAAATTGAAGTTTCAGAGCTACACA AACACTTTTTCTGTCCCAACCGTTCCCTCACAGCAAAGCAACAATACAGGCTAGGGATGGTAATCCTTT AAACATACAAAAATTGCTCGTGTTATAAATTACCCAGTTTAGAGGGGAAAAAAAAACAATTATTCCTAA ATAAATGGATAAGTAGAATTAATGGTTGAGGCAGGACCATACAGAGTGTGGGAACTGCTGGGGATCTAG GGAATTCAGTGGGACCAATGAAAGCATGGCTGAGAAATAGCAGGTAGTCCAGGATAGTCTAAGGGAGGT GTTCCCATCTGAGCCCAGAGATAAGGGTGTCTTCCTAGAACATTAGCCGTAGTGGAATTAACAGGAAAT CATGAGGGTGACGTAGAATTGAGTCTTCCAGGGGACTCTATCAGAACTGGACCATCTCCAAGTATATAA CGATGAGTCCTCTTAATGCTAGGAGTAGAAAATGGTCCTAGGAAGGGGACTGAGGATTGCGGTGGGGGG TGGGGTGGAAAAGAAAGTACAGAACAAACCCTGTGTCACTGTCCCAAGTTGCTAAGTGAACAGAACTAT CTCAGCATCAGAATGAGAAAGCCTGAGAAGAAAGAACCAACCACAAGCACACAGGAAGGAAAGCGCAGG AGGTGAAAATGCTTTCTTGGCCAGGGTAGTAAGAATTAGAGGTTAATGCAGGGACTGTAAAACCACCTT TTCTGCTTCAATATCTAATTCCTGTGTAGCTTTGTTCATTGCATTTATTAAACAAATGTTGTATAACCA ATACTAAATGTACTACTGAGCTTCGCTGAGTTAAGTTATGAAACTTTCAAATCCTTCATCATGTCAGTT CCAATGAGGTGGGGATGGAGAAGACAATTGTTGCTTATGAAAGAAAGCTTTAGCTGTCTCTGTTTTGTA AGCTTTAAGCGCAACATTTCTTGGTTCCAATAAAGCATTTTACAAGATCTTGCATGCTACTCTTAGATA GAAGATGGGAAAACCATGGTAATAAAATATGAATGATAAAA ACGCGTAAGCGGCCGCGGCATCTAGATTCGAAGAAAATGACCGACCAAGCGACGCCCAACCTGCCATCA CGAGATTTCGATTCCACCGCCGCCTTCTATGAAAGG
Restriction Sites	SgfI-MluI
OTI Disclaimer	Our molecular clone sequence data has been matched to the sequence identifier above as a point of reference. Note that the complete sequence of this clone is largely the same as the reference sequence but may contain minor differences , e.g., single nucleotide polymorphisms (SNPs).
Reference Data
RefSeq	NM_001127595.2
Synonyms	CD16; CD16A; FCG3; FCGR3; FCGRIII; FCR-10; FCRIII; FCRIIIA; IGFR3; IMD20
Summary	This gene encodes a receptor for the Fc portion of immunoglobulin G, and it is involved in the removal of antigen-antibody complexes from the circulation, as well as other responses, including antibody dependent cellular mediated cytotoxicity and antibody dependent enhancement of virus infections. This gene (FCGR3A) is highly similar to another nearby gene (FCGR3B) located on chromosome 1. The receptor encoded by this gene is expressed on natural killer (NK) cells as an integral membrane glycoprotein anchored through a transmembrane peptide, whereas FCGR3B is expressed on polymorphonuclear neutrophils (PMN) where the receptor is anchored through a phosphatidylinositol (PI) linkage. Mutations in this gene are associated with immunodeficiency 20, and have been linked to susceptibility to recurrent viral infections, susceptibility to systemic lupus erythematosus, and alloimmune neonatal neutropenia. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2020]
Locus ID	2214
MW	47.8

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