Wilms Tumor Protein (WT1) (NM_000378) Human 3' UTR Clone

Specifications

Product Data
Product Name	Wilms Tumor Protein (WT1) (NM_000378) Human 3' UTR Clone
Vector	pMirTarget
Synonyms	AWT1; GUD; NPHS4; WAGR; WIT-2; WT33
ACCN	NM_000378
Insert Size	1313 bp
Sequence Data	Insert Sequence (showhide) >SC213658 3’UTR clone of NM_000378 The sequence shown below is from the reference sequence of NM_000378. The complete sequence of this clone may contain minor differences, such as SNPs. Blue=Stop Codon Red=Cloning site GGCAAGTTGGACGCCCGCAAGATCCGCGAGATTCTCATTAAGGCCAAGAAGGGCGGAAAGATCGCCGTG TAACAATTGGCAGAGCTCAGAATTCAAGCGATCGCC AACATGACCAAACTCCAGCTGGCGCTTTGAGGGGTCTCCCTCGGGGACCGTTCAGTGTCCCAGGCAGCA CAGTGTGTGAACTGCTTTCAAGTCTGACTCTCCACTCCTCCTCACTAAAAAGGAAACTTCAGTTGATCT TCTTCATCCAACTTCCAAGACAAGATACCGGTGCTTCTGGAAACTACCAGGTGTGCCTGGAAGAGTTGG TCTCTGCCCTGCCTACTTTTAGTTGACTCACAGGCCCTGGAGAAGCAGCTAACAATGTCTGGTTAGTTA AAAGCCCATTGCCATTTGGTGTGGATTTTCTACTGTAAGAAGAGCCATAGCTGATCATGTCCCCCTGAC CCTTCCCTTCTTTTTTTATGCTCGTTTTCGCTGGGGATGGAATTATTGTACCATTTTCTATCATGGAAT ATTTATAGGCCAGGGCATGTGTATGTGTCTGCTAATGTAAACTTTGTCATGGTTTCCATTTACTAACAG CAACAGCAAGAAATAAATCAGAGAGCAAGGCATCGGGGGTGAATCTTGTCTAACATTCCCGAGGTCAGC CAGGCTGCTAACCTGGAAAGCAGGATGTAGTTCTGCCAGGCAACTTTTAAAGCTCATGCATTTCAAGCA GCTGAAGAAAAAATCAGAACTAACCAGTACCTCTGTATAGAAATCTAAAAGAATTTTACCATTCAGTTA ATTCAATGTGAACACTGGCACACTGCTCTTAAGAAACTATGAAGATCTGAGATTTTTTTGTGTATGTTT TTGACTCTTTTGAGTGGTAATCATATGTGTCTTTATAGATGTACATACCTCCTTGCACAAATGGAGGGG AATTCATTTTCATCACTGGGAGTGTCCTTAGTGTATAAAAACCATGCTGGTATATGGCTTCAAGTTGTA AAAATGAAAGTGACTTTAAAAGAAAATAGGGGATGGTCCAGGATCTCCACTGATAAGACTGTTTTTAAG TAACTTAAGGACCTTTGGGTCTACAAGTATATGTGAAAAAAATGAGACTTACTGGGTGAGGAAATCCAT TGTTTAAAGATGGTCGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTTGTGTTGTGTTTTGTTTTTT AAGGGAGGGAATTTATTATTTACCGTTGCTTGAAATTACTGTGTAAATATATGTCTGATAATGATTTGC TCTTTGACAACTAAAATTAGGACTGTATAAGTACTAGATGCATCACTGGGTGTTGATCTTACAAGATAT TGATGATAACACTTAAAATTGTAACCTGCATTTTTCACTTTGCTCTCAATTAAAGTCTATTCAAAAGGA AA ACGCGTAAGCGGCCGCGGCATCTAGATTCGAAGAAAATGACCGACCAAGCGACGCCCAACCTGCCATCA CGAGATTTCGATTCCACCGCCGCCTTCTATGAAAGG
Restriction Sites	SgfI-MluI
OTI Disclaimer	Our molecular clone sequence data has been matched to the sequence identifier above as a point of reference. Note that the complete sequence of this clone is largely the same as the reference sequence but may contain minor differences , e.g., single nucleotide polymorphisms (SNPs).
Reference Data
RefSeq	NM_000378.6
Synonyms	AWT1; GUD; NPHS4; WAGR; WIT-2; WT33
Summary	This gene encodes a transcription factor that contains four zinc-finger motifs at the C-terminus and a proline/glutamine-rich DNA-binding domain at the N-terminus. It has an essential role in the normal development of the urogenital system, and it is mutated in a small subset of patients with Wilms tumor. This gene exhibits complex tissue-specific and polymorphic imprinting pattern, with biallelic, and monoallelic expression from the maternal and paternal alleles in different tissues. Multiple transcript variants have been described. In several variants, there is evidence for the use of a non-AUG (CUG) translation initiation codon upstream of, and in-frame with the first AUG. Authors of PMID:7926762 also provide evidence that WT1 mRNA undergoes RNA editing in human and rat, and that this process is tissue-restricted and developmentally regulated. [provided by RefSeq, Mar 2015]
Locus ID	7490
MW	49.8

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