MRP5 (ABCC5) (NM_001023587) Human 3' UTR Clone

Specifications

Product Data
Product Name	MRP5 (ABCC5) (NM_001023587) Human 3' UTR Clone
Vector	pMirTarget
Synonyms	ABC33; EST277145; MOAT-C; MOATC; MRP5; pABC11; SMRP
ACCN	NM_001023587
Insert Size	1211 bp
Sequence Data	Insert Sequence (showhide) >SC213255 3’UTR clone of NM_001023587 The sequence shown below is from the reference sequence of NM_001023587. The complete sequence of this clone may contain minor differences, such as SNPs. Blue=Stop Codon Red=Cloning site GGCAAGTTGGACGCCCGCAAGATCCGCGAGATTCTCATTAAGGCCAAGAAGGGCGGAAAGATCGCCGTG TAACAATTGGCAGAGCTCAGAATTCAAGCGATCGCC CAGGATGGCTGTATTCTGCGGTCAGAATGAGAGAGTCAAGCTGGGCAGAATCTCTCGCCAAGAGTTCAG CCTTCCTTTGGAGACTGCTCCATCAGTGCCGAGGTGTGTGGGAACAGGCTTCACTGCACCGCCATCTTA CTGAGTTGCTTCACGTGAGGAAAAGGGGGCTTTGGCCCTGTGACTCAGTTCCACATTTTGGATTGCATA CTGGAAAAGAAGCCAATCTTCTTGCTAGTAAACCAGCAACCCGGCTGTATACAGTGGTGACCCAAGCAA TGGATATAAACCTAAAAATCTGAGGGAGGGGAGAGGTGGAATACAGTAGTTCTTGGAATCTGAAGTCTC CTATTTGATCAGGTTATTTCCTGGGACTTGGCAAAAATCTGATTGGTGGGGATCTCCTAGGACCTAGTG GACATCTGGTATTAATTTAATCTCAGGAAAAACAAGAAATTAACCCAGAGAGAGTCTGGGTTTTGGAAT TCAGCGTAGCTACCTCCAGACCGTGGTGTCTGGCCTCCATTTTTGTCTGTCATTCAGCTCTGACTTACA GCTGCAGTCACCTTTGCTATAAGGCACCTGGGTAGAAGGGTGGATGGGCTTCACATCAATTTTTTTCTT CCTTTAGGGTGGGGGATTGGTTTGGCTTTCTTTTGTTGTGGTTTTTTGTTTTATTTTTGTCAAGATTGA TTTTTAGATGCAAGGACTTGAAAAGACCCAGAAGGATGCCACCAGTTTTTCCTTGAGGCCTAGGATTTT TTATTCTGTCCCGAGCAGAGGTAATTCCTCACAACTTAGTGCACCAGTAGCACCAGCCATTTTGAGCAG AGTACCTCTTTGGGGAGCTTTTCGTTTTGTTTTGTTTTTAATTCTCTTTCCTTAGCAGCAAGGTCTTTT TTCCTAGAGAATCTACTCCGTTGCAGAATCATTGCAACCTCAGGAGCCCTCACTGATTGAGTGCTGTCA GCCTGATATACTACTTTGGACTCTGGAAACAGATATGGGTTCTATTCTCTATTTCTACTGTGTGTCGTT AAACAACCGTCGGAGACCAGATGACCTGTTAGATGGCTAGTCCTGTATAACTCGACTCTGTATGTTTCA ATGTATGTTACTGCAATGCTTCACCTGCTGTACAGTGTTTGTGAGATGCTCTTTGAAGATGGTACTTTT ATATTTTTTCATTTTCAATAAAAGTACATTCCTTCCCA ACGCGTAAGCGGCCGCGGCATCTAGATTCGAAGAAAATGACCGACCAAGCGACGCCCAACCTGCCATCA CGAGATTTCGATTCCACCGCCGCCTTCTATGAAAGG
Restriction Sites	SgfI-MluI
OTI Disclaimer	Our molecular clone sequence data has been matched to the sequence identifier above as a point of reference. Note that the complete sequence of this clone is largely the same as the reference sequence but may contain minor differences , e.g., single nucleotide polymorphisms (SNPs).
Reference Data
RefSeq	NM_001023587.3
Synonyms	ABC33; EST277145; MOAT-C; MOATC; MRP5; pABC11; SMRP
Summary	The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MRP subfamily which is involved in multi-drug resistance. This protein functions in the cellular export of its substrate, cyclic nucleotides. This export contributes to the degradation of phosphodiesterases and possibly an elimination pathway for cyclic nucleotides. Studies show that this protein provides resistance to thiopurine anticancer drugs, 6-mercatopurine and thioguanine, and the anti-HIV drug 9-(2-phosphonylmethoxyethyl)adenine. This protein may be involved in resistance to thiopurines in acute lymphoblastic leukemia and antiretroviral nucleoside analogs in HIV-infected patients. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2016]
Locus ID	10057
MW	45.8

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