Dematin (DMTN) (NM_001114135) Human 3' UTR Clone

Specifications

Product Data
Product Name	Dematin (DMTN) (NM_001114135) Human 3' UTR Clone
Vector	pMirTarget
Synonyms	DMT; EPB49
ACCN	NM_001114135
Insert Size	1092 bp
Sequence Data	Insert Sequence (showhide) >SC212517 3’UTR clone of NM_001114135 The sequence shown below is from the reference sequence of NM_001114135. The complete sequence of this clone may contain minor differences, such as SNPs. Blue=Stop Codon Red=Cloning site GGCAAGTTGGACGCCCGCAAGATCCGCGAGATTCTCATTAAGGCCAAGAAGGGCGGAAAGATCGCCGTG TAACAATTGGCAGAGCTCAGAATTCAAGCGATCGCC GAGCTCAAGAAGAAGGCCTCTCTCTTCTGATGGCCCCCACCTGCTCCGGGACGGCCCCCTTACCCCTGC TGCTTCAGGGTTTTTCCCCGGCGGGTTGGGAGGGGCAGGAGGTGGGGTGGAAATAGGGTGGGCTCCTTT CCTCAGGTAGAGTGGGGGGCCAAAACCTCTGCAGTCCCCGGCAGTGAGCTATGGACTTTCTTCCCCCTC ACAAGGCTGGGGGCCTCCTGCTCTCGTCCCTGGCCCTCCCTGCACAGGGCAAAGCCAGTCTGGGCTCTG GCACACAGAGTTCATGTTTGCGCCCTCTCCCTGCCCCTCACCCCAGAGGGTGAGGAGGAATGAGGGGCA TTGGTGGTTAGGCCGGTTGGCTGTCTTGAACAGCTGGAGGGAAGATGCAGGGGTGGGAAGCGGCCAGGC AGAAAGAGCTCCAGGCTCTTGTGTCGCCCACCCAGCCCTCCCATACTCACTCCTGACAGCTTTCCTGCA CTGCAGCCTCCTGCTCCTCTGACTCTAGTGGGAACAGGCCCCAGCTCAGCCTCCGGCAGGGAGGTCACC CCTCCACTTCAGCTTGCCCTGACCTCCGCTCGCAAACCCCGAGCTTCCAAGCCTTTTGCTCCAGCCCTG CGGCTTCCCCAGAAGCCTGGGCTTAGGGTGGAGATGCCGCCTACACACGATCCTGGCCCTCCACCTGCC TCCAGGCCACGAAATGGGAATTCCAGCACTAAGCCAGGCACCGGGCAGAAGCTGGGCCTTCCGCCTCCC TTGGATGGGGTCAAGAGGCCAGGCCTGGCACATTTTGGAGTGTCCTGGCTACCAGCTCTCACCTACACC CACGCACCCCCCCACACACTATGCTCTCTCAAGAATGTAATTTATTGGGGCCCCCCCAGCTGCTTTCCT CACCTGCCCCTGCCCTACCTTACACCCCCAGCTTGACTTCTTTCCAGTCCACGTGTGTATATAATGATA TCTATATTTTTGCCCAGGTCTGGGTATTGCTCCTGCCCAGACCCTGACATCCCTTTCCACTGTGTGTGT GACCATGCTGGGGGAGGGGGACTCTGCTTGGAATTAAAAGGTTGCATTGGGTCCCTA ACGCGTAAGCGGCCGCGGCATCTAGATTCGAAGAAAATGACCGACCAAGCGACGCCCAACCTGCCATCA CGAGATTTCGATTCCACCGCCGCCTTCTATGAAAGG
Restriction Sites	SgfI-MluI
OTI Disclaimer	Our molecular clone sequence data has been matched to the sequence identifier above as a point of reference. Note that the complete sequence of this clone is largely the same as the reference sequence but may contain minor differences , e.g., single nucleotide polymorphisms (SNPs).
Reference Data
RefSeq	NM_001114135.5
Synonyms	DMT; EPB49
Summary	The protein encoded by this gene is an actin binding and bundling protein that plays a structural role in erythrocytes, by stabilizing and attaching the spectrin/actin cytoskeleton to the erythrocyte membrane in a phosphorylation-dependent manner. This protein contains a core domain in the N-terminus, and a headpiece domain in the C-terminus that binds F-actin. When purified from erythrocytes, this protein exists as a trimer composed of two 48 kDa polypeptides and a 52 kDa polypeptide. The different subunits arise from alternative splicing in the 3' coding region, where the headpiece domain is located. Disruption of this gene has been correlated with the autosomal dominant Marie Unna hereditary hypotrichosis disease, while loss of heterozygosity of this gene is thought to play a role in prostate cancer progression. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Nov 2014]
Locus ID	2039
MW	39.2

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