RANKL (TNFSF11) (NM_033012) Human 3' UTR Clone

CAT#: SC212507

3' UTR clone of tumor necrosis factor (ligand) superfamily member 11 (TNFSF11) transcript variant 2 for miRNA target validation



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CNY 4,845.00


货期*
3周

规格
    • 10 ug

Cited in 1 publication.

Product images

经常一起买 (2)
Firefly luciferase assay kit, 150 assays
    • 1 kit

CNY 1,520.00


DH5α Chemically Competent Cells (≥10^8 cfu/μg of pUC19 DNA)
    • 5 x 200 ul

CNY 1,280.00

Specifications

Product Data
Product Name RANKL (TNFSF11) (NM_033012) Human 3' UTR Clone
Vector pMirTarget
Synonyms CD254; hRANKL2; ODF; OPGL; OPTB2; RANKL; sOdf; TNLG6B; TRANCE
ACCN NM_033012
Insert Size 1125 bp
Sequence Data
>SC212507 3’UTR clone of NM_033012
The sequence shown below is from the reference sequence of NM_033012. The complete sequence of this clone may contain minor differences, such as SNPs.
Blue=Stop Codon Red=Cloning site

GGCAAGTTGGACGCCCGCAAGATCCGCGAGATTCTCATTAAGGCCAAGAAGGGCGGAAAGATCGCCGTG
TAACAATTGGCAGAGCTCAGAATTCAAGCGATCGCC
GGGGCTTTTAAAGTTCGAGATATAGATTGAGCCCCAGTTTTTGGAGTGTTATGTATTTCCTGGATGTTT
GGAAACATTTTTTAAAACAAGCCAAGAAAGATGTATATAGGTGTGTGAGACTACTAAGAGGCATGGCCC
CAACGGTACACGACTCAGTATCCATGCTCTTGACCTTGTAGAGAACACGCGTATTTACAGCCAGTGGGA
GATGTTAGACTCATGGTGTGTTACACAATGGTTTTTAAATTTTGTAATGAATTCCTAGAATTAAACCAG
ATTGGAGCAATTACGGGGTGACCTTATGAGAAACTGCATGTGGGCTATGGGAGGGGTTGGTCCCTGGTC
ATGTGCCCCTTCGCAGCTGAAGTGGAGAGGGTGTCATCTAGCGCAATTGAAGGATCATCTGAAGGGGCA
AATTCTTTTGAATTGTTACATCATGCTGGAACCTGCAAAAAATACTTTTTCTAATGAGGAGAGAAAATA
TATGTATTTTTATATAATATCTAAAGTTATATTTCAGATGTAATGTTTTCTTTGCAAAGTATTGTAAAT
TATATTTGTGCTATAGTATTTGATTCAAAATATTTAAAAATGTCTTGCTGTTGACATATTTAATGTTTT
AAATGTACAGACATATTTAACTGGTGCACTTTGTAAATTCCCTGGGGAAAACTTGCAGCTAAGGAGGGG
AAAAAAATGTTGTTTCCTAATATCAAATGCAGTATATTTCTTCGTTCTTTTTAAGTTAATAGATTTTTT
CAGACTTGTCAAGCCTGTGCAAAAAAATTAAAATGGATGCCTTGAATAATAAGCAGGATGTTGGCCACC
AGGTGCCTTTCAAATTTAGAAACTAATTGACTTTAGAAAGCTGACATTGCCAAAAAGGATACATAATGG
GCCACTGAAATCTGTCAAGAGTAGTTATATAATTGTTGAACAGGTGTTTTTCCACAAGTGCCGCAAATT
GTACCTTTTTTGTTTTTTCAAAATAGAAAAGTTATTAGTGGTTTATCAGCAAAAAAGTCCAATTTTAAT
TTAGTAAATGTTATCTTATACTGTACAATAAAAACATTGCCTTTGAATGTTAATTTTTTGGTACAAAAA
TAAATTTATATGAAAACCTGC
AGCGGACCGACTTACGCGTAAGCGGCCGCGGCATCTAGATTCGAAGAAAATGACCGACCAAGCGACGCC
CAACCTGCCATCACGAGATTTCGATTCCACCGCCGC
Restriction Sites SgfI-RsrII     
OTI Disclaimer Our molecular clone sequence data has been matched to the sequence identifier above as a point of reference. Note that the complete sequence of this clone is largely the same as the reference sequence but may contain minor differences , e.g., single nucleotide polymorphisms (SNPs).
Reference Data
RefSeq NM_033012.4
Synonyms CD254; hRANKL2; ODF; OPGL; OPTB2; RANKL; sOdf; TNLG6B; TRANCE
Summary This gene encodes a member of the tumor necrosis factor (TNF) cytokine family which is a ligand for osteoprotegerin and functions as a key factor for osteoclast differentiation and activation. This protein was shown to be a dentritic cell survival factor and is involved in the regulation of T cell-dependent immune response. T cell activation was reported to induce expression of this gene and lead to an increase of osteoclastogenesis and bone loss. This protein was shown to activate antiapoptotic kinase AKT/PKB through a signaling complex involving SRC kinase and tumor necrosis factor receptor-associated factor (TRAF) 6, which indicated this protein may have a role in the regulation of cell apoptosis. Targeted disruption of the related gene in mice led to severe osteopetrosis and a lack of osteoclasts. The deficient mice exhibited defects in early differentiation of T and B lymphocytes, and failed to form lobulo-alveolar mammary structures during pregnancy. Two alternatively spliced transcript variants have been found. [provided by RefSeq, Jul 2008]
Locus ID 8600
MW 43.1
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Citations (1)

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