C9orf72 (NM_145005) Human 3' UTR Clone

Specifications

Product Data
Product Name	C9orf72 (NM_145005) Human 3' UTR Clone
Vector	pMirTarget
Synonyms	ALSFTD; DENND9; DENNL72; FTDALS; FTDALS1
ACCN	NM_145005
Insert Size	1187 bp
Sequence Data	Insert Sequence (showhide) >SC212481 3’UTR clone of NM_145005 The sequence shown below is from the reference sequence of NM_145005. The complete sequence of this clone may contain minor differences, such as SNPs. Blue=Stop Codon Red=Cloning site GGCAAGTTGGACGCCCGCAAGATCCGCGAGATTCTCATTAAGGCCAAGAAGGGCGGAAAGATCGCCGTG TAACAATTGGCAGAGCTCAGAATTCAAGCGATCGCC AGCTGTCATGAAGGCTTTCTTCTCAAGTAAGAATTTTTCTTTTCATAAAAGCTGGATGAAGCAGATACC ATCTTATGCTCACCTATGACAAGATTTGGAAGAAAGAAAATAACAGACTGTCTACTTAGATTGTTCTAG GGACATTACGTATTTGAACTGTTGCTTAAATTTGTGTTATTTTTCACTCATTATATTTCTATATATATT TGGTGTTATTCCATTTGCTATTTAAAGAAACCGAGTTTCCATCCCAGACAAGAAATCATGGCCCCTTGC TTGATTCTGGTTTCTTGTTTTACTTCTCATTAAAGCTAACAGAATCCTTTCATATTAAGTTGTACTGTA GATGAACTTAAGTTATTTAGGCGTAGAACAAAATTATTCATATTTATACTGATCTTTTTCCATCCAGCA GTGGAGTTTAGTACTTAAGAGTTTGTGCCCTTAAACCAGACTCCCTGGATTAATGCTGTGTACCCGTGG GCAAGGTGCCTGAATTCTCTATACACCTATTTCCTCATCTGTAAAATGGCAATAATAGTAATAGTACCT AATGTGTAGGGTTGTTATAAGCATTGAGTAAGATAAATAATATAAAGCACTTAGAACAGTGCCTGGAAC ATAAAAACACTTAATAATAGCTCATAGCTAACATTTCCTATTTACATTTCTTCTAGAAATAGCCAGTAT TTGTTGAGTGCCTACATGTTAGTTCCTTTACTAGTTGCTTTACATGTATTATCTTATATTCTGTTTTAA AGTTTCTTCACAGTTACAGATTTTCATGAAATTTTACTTTTAATAAAAGAGAAGTAAAAGTATAAAGTA TTCACTTTTATGTTCACAGTCTTTTCCTTTAGGCTCATGATGGAGTATCAGAGGCATGAGTGTGTTTAA CCTAAGAGCCTTAATGGCTTGAATCAGAAGCACTTTAGTCCTGTATCTGTTCAGTGTCAGCCTTTCATA CATCATTTTAAATCCCATTTGACTTTAAGTAAGTCACTTAATCTCTCTACATGTCAATTTCTTCAGCTA TAAAATGATGGTATTTCAATAAATAAATACATTAATTAAATGATATTATACTGACTAATTGGGCTGTTT TAAGGCTCAATAAGAAAATTTCTGTGAAAGGTCTCTAGAAAATGTAGGTTCCTATACAAATAAAAGATA ACATTGTGCTTATA ACGCGTAAGCGGCCGCGGCATCTAGATTCGAAGAAAATGACCGACCAAGCGACGCCCAACCTGCCATCA CGAGATTTCGATTCCACCGCCGCCTTCTATGAAAGG
Restriction Sites	SgfI-MluI
OTI Disclaimer	Our molecular clone sequence data has been matched to the sequence identifier above as a point of reference. Note that the complete sequence of this clone is largely the same as the reference sequence but may contain minor differences , e.g., single nucleotide polymorphisms (SNPs).
Reference Data
RefSeq	NM_145005.7
Synonyms	ALSFTD; DENND9; DENNL72; FTDALS; FTDALS1
Summary	The protein encoded by this gene plays an important role in the regulation of endosomal trafficking, and has been shown to interact with Rab proteins that are involved in autophagy and endocytic transport. Expansion of a GGGGCC repeat from 2-22 copies to 700-1600 copies in the intronic sequence between alternate 5' exons in transcripts from this gene is associated with 9p-linked ALS (amyotrophic lateral sclerosis) and FTD (frontotemporal dementia) (PMID: 21944778, 21944779). Studies suggest that hexanucleotide expansions could result in the selective stabilization of repeat-containing pre-mRNA, and the accumulation of insoluble dipeptide repeat protein aggregates that could be pathogenic in FTD-ALS patients (PMID: 23393093). Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2016]
Locus ID	203228
MW	46.6

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