NOTCH3 (NM_000435) Human 3' UTR Clone

Specifications

Product Data
Product Name	NOTCH3 (NM_000435) Human 3' UTR Clone
Vector	pMirTarget
Synonyms	CADASIL; CADASIL1; CASIL; IMF2; LMNS
ACCN	NM_000435
Insert Size	1654 bp
Sequence Data	Insert Sequence (showhide) >SC212056 3’UTR clone of NM_000435 The sequence shown below is from the reference sequence of NM_000435. The complete sequence of this clone may contain minor differences, such as SNPs. Blue=Stop Codon Red=Cloning site GGCAAGTTGGACGCCCGCAAGATCCGCGAGATTCTCATTAAGGCCAAGAAGGGCGGAAAGATCGCCGTG TAACAATTGGCAGAGCTCAGAATTCAAGCGATCGCC GTTACCCCCAAGAGGCAAGTGTTGGCCTGAGACGCTCGTCAGTTCTTAGATCTTGGGGGCCTAAAGAGA CCCCCGTCCTGCCTCCTTTCTTTCTCTGTCTCTTCCTTCCTTTTAGTCTTTTTCATCCTCTTCTCTTTC CACCAACCCTCCTGCATCCTTGCCTTGCAGCGTGACCGAGATAGGTCATCAGCCCAGGGCTTCAGTCTT CCTTTATTTATAATGGGTGGGGGCTACCACCCACCCTCTCAGTCTTGTGAAGAGTCTGGGACCTCCTTC TTCCCCACTTCTCTCTTCCCTCATTCCTTTCTCTCTCCTTCTGGCCTCTCATTTCCTTACACTCTGACA TGAATGAATTATTATTATTTTTATTTTTCTTTTTTTTTTTACATTTTGTATAGAAACAAATTCATTTAA ACAAACTTATTATTATTATTTTTTACAAAATATATATATGGAGATGCTCCCTCCCCCTGTGAACCCCCC AGTGCCCCCGTGGGGCTGAGTCTGTGGGCCCATTCGGCCAAGCTGGATTCTGTGTACCTAGTACACAGG CATGACTGGGATCCCGTGTACCGAGTACACGACCCAGGTATGTACCAAGTAGGCACCCTTGGGCGCACC CACTGGGGCCAGGGGTCGGGGGAGTGTTGGGAGCCTCCTCCCCACCCCACCTCCCTCACTTCACTGCAT TCCAGATGGGACATGTTCCATAGCCTTGCTGGGGAAGGGCCCACTGCCAACTCCCTCTGCCCCAGCCCC ACCCTTGGCCATCTCCCTTTGGGAACTAGGGGGCTGCTGGTGGGAAATGGGAGCCAGGGCAGATGTATG CATTCCTTTGTGTCCCTGTAAATGTGGGACTACAAGAAGAGGAGCTGCCTGAGTGGTACTTTCTCTTCC TGGTAATCCTCTGGCCCAGCCTCATGGCAGAATAGAGGTATTTTTAGGCTATTTTTGTAATATGGCTTC TGGTCAAAATCCCTGTGTAGCTGAATTCCCAAGCCCTGCATTGTACAGCCCCCCACTCCCCTCACCACC TAATAAAGGAATAGTTAACACTCAGTGTTGTTGGTCTGTGTCTAGGTAAGGTGGGGAGTGGTGGCAGTG GGACTTCTATCTCCCCCACCCAGGGCTAACTTGAGCTCCCATCTTGGGGTAAATACATTTGACTTGCCA GTCTACTTATGCTTCCTCTTTTGGCAGATGACTACCGATTGGATTAGTGGTTGTCACCTGACTTAAGCT GAGCCAATCAGATTCTTTTGCTCGAGAACTTTCTTTAATGGAGAGGCTAAGAAAGTTGTCAGTTGGTGG AGCTCTTAAGGTCACAATCAGATTTAGAAATATCAGTGGCCAATTCGAGGTGGTGGGCAAAGAGACAAG CAAACAGGGCAGAAGAATGAAGCTAATATTCAGGGAGAATCAGAAATGAGAGCTCAAATGGCTCCTTGA GGGCTGGGGGGGTTATCTCGGCTCCCAGTGCAGTTATCAATTCCAGTTAATTGAGTGTTCATTCCATTG AGATCAACAGGTATTTATTAATTGCTTTCTAAGTATCTGATCATGGTTCTGCATGAATTTCACTTTTAC TTCATGCTCCTATGGGTTTTGGAGATAACCTTGGACCCATGTAATAAATACTTCTTTACTTGTGCCA ACGCGTAAGCGGCCGCGGCATCTAGATTCGAAGAAAATGACCGACCAAGCGACGCCCAACCTGCCATCA CGAGATTTCGATTCCACCGCCGCCTTCTATGAAAGG
Restriction Sites	SgfI-MluI
OTI Disclaimer	Our molecular clone sequence data has been matched to the sequence identifier above as a point of reference. Note that the complete sequence of this clone is largely the same as the reference sequence but may contain minor differences , e.g., single nucleotide polymorphisms (SNPs).
Reference Data
RefSeq	NM_000435.3
Synonyms	CADASIL; CADASIL1; CASIL; IMF2; LMNS
Summary	This gene encodes the third discovered human homologue of the Drosophilia melanogaster type I membrane protein notch. In Drosophilia, notch interaction with its cell-bound ligands (delta, serrate) establishes an intercellular signalling pathway that plays a key role in neural development. Homologues of the notch-ligands have also been identified in human, but precise interactions between these ligands and the human notch homologues remains to be determined. Mutations in NOTCH3 have been identified as the underlying cause of cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL). [provided by RefSeq, Jul 2008]
Locus ID	4854
MW	62.3

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