CNOT1 (NM_016284) Human 3' UTR Clone

Specifications

Product Data
Product Name	CNOT1 (NM_016284) Human 3' UTR Clone
Vector	pMirTarget
Synonyms	AD-005; CDC39; HPE12; NOT1; NOT1H
ACCN	NM_016284
Insert Size	1037 bp
Sequence Data	Insert Sequence (showhide) >SC211909 3’UTR clone of NM_016284 The sequence shown below is from the reference sequence of NM_016284. The complete sequence of this clone may contain minor differences, such as SNPs. Blue=Stop Codon Red=Cloning site GGCAAGTTGGACGCCCGCAAGATCCGCGAGATTCTCATTAAGGCCAAGAAGGGCGGAAAGATCGCCGTG TAACAATTGGCAGAGCTCAGAATTCAAGCGATCGCC CAAGTAATGGAAGGGACAGGTGCCAGTTAGACGAAACTGCATCTCTGTTGTACGTGTCAGTCTAGAGGT CTCACTGCACCGAGTTCATAAACTGACTGAAGAATCCTTTCAGCTCTTCCTGACTTTCCCAGCCCTTTG GTTTGTGGGTATCTGCCCCAACTACTGTTGGGATCAGCCTCCTGTCTTATGTGGGCACGTTCCAAAGTT TAAATGCATTTTTTTGACTCTTGGCCAAAATTTAGAAGATGCTGTGAATATCATTTTGAACTTGTGTAA ATACATGAAAGAGAAAACCTTTGTCTGGAACTTCTTGGCTTTGTGCAAGCTGTGTCCAAGGCAAGTACA TAAACTGGTACCTTGTAATGAAGAGGCAGCTGATGCCATGCACTTGTCTGAGGGCATAGCTCCATGTCT TCTGACATTCCTGGTGTCCCAAAGAATAGCAAAAAGCCAGTTTGAATATTATGTAACTTATTTTTTTAA TGTGGACAGGGGACCTTGAAAATCACTAAGTTATTAAAAATGTGGATGTGCTAGAATTGGATATGTCCA GGAACATGGGAAGGGCTCACTATTGGAATCCCATGAGTTTCCATTTTGTCTCTACCCAAACGTATTCCA AAGCTGACTGCATTTGTACCATCTTATTTCTTTTGGGGATTATACACCTCAGCCGCCTGAGATGGGGGT CAGCTCTTTATATAAAGGGAAACCAGACCAGGCCTAAAGCCCACCCCTACCCTCACCCCCCCAATCCTC TCCTGAAACTTAAAAACAGTGGGAATATAGGAAAGGGAACCAAATCTCATTAATTAATTGTTCTCCCCC ATTACCCCACTGAATGAATGGCCATACAGGCTAAGCTGAATAATGACAAAGTTGAAAGGACCAATACAG CCCCTTTTATAAGGATTTTGAATGTTTTGCAAATGTATTGGTCCCTGTGTTGTATTTTGTAGCCTTTTC CTGGGCTTCAGCTCCCCTACTTCTTGTATGTGTATGCATACTGTAGCTAACCATTAAAGTCATGACACA CA ACGCGTAAGCGGCCGCGGCATCTAGATTCGAAGAAAATGACCGACCAAGCGACGCCCAACCTGCCATCA CGAGATTTCGATTCCACCGCCGCCTTCTATGAAAGG
Restriction Sites	SgfI-MluI
OTI Disclaimer	Our molecular clone sequence data has been matched to the sequence identifier above as a point of reference. Note that the complete sequence of this clone is largely the same as the reference sequence but may contain minor differences , e.g., single nucleotide polymorphisms (SNPs).
Reference Data
RefSeq	NM_016284.5
Synonyms	AD-005; CDC39; HPE12; NOT1; NOT1H
Summary	Scaffolding component of the CCR4-NOT complex which is one of the major cellular mRNA deadenylases and is linked to various cellular processes including bulk mRNA degradation, miRNA-mediated repression, translational repression during translational initiation and general transcription regulation. Additional complex functions may be a consequence of its influence on mRNA expression. Its scaffolding function implies its interaction with the catalytic complex module and diverse RNA-binding proteins mediating the complex recruitment to selected mRNA 3' UTRs. Involved in degradation of AU-rich element (ARE)-containing mRNAs probably via association with ZFP36. Mediates the recruitment of the CCR4-NOT complex to miRNA targets and to the RISC complex via association with TNRC6A, TNRC6B or TNRC6C. Acts as a transcriptional repressor. Represses the ligand-dependent transcriptional activation by nuclear receptors. Involved in the maintenance of embryonic stem (ES) cell identity.[UniProtKB/Swiss-Prot Function]
Locus ID	23019
MW	38.3

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