PDHX (NM_003477) Human 3' UTR Clone

Specifications

Product Data
Product Name	PDHX (NM_003477) Human 3' UTR Clone
Vector	pMirTarget
Synonyms	DLDBP; E3BP; OPDX; PDHXD; PDX1; proX
ACCN	NM_003477
Insert Size	986 bp
Sequence Data	Insert Sequence (showhide) >SC211371 3’UTR clone of NM_003477 The sequence shown below is from the reference sequence of NM_003477. The complete sequence of this clone may contain minor differences, such as SNPs. Blue=Stop Codon Red=Cloning site GGCAAGTTGGACGCCCGCAAGATCCGCGAGATTCTCATTAAGGCCAAGAAGGGCGGAAAGATCGCCGTG TAACAATTGGCAGAGCTCAGAATTCAAGCGATCGCC AACCTAGAGAATCCTATCCGACTTGCCTAGTCCTCAAAGATAAGAAGTTGGTGTTCAGCTTAGTTGATT CAGTAGTTGTTACCAAGAAACATATGTTATAGGAAAACAACTTGGTATTTAAGTATGAAGTGGATGAAA TGTTTATTTATTTAAGGTGAAAGCATTTGACCCAGGGTGTCTTCATCTTCAATTTGGGTTTAATGTTAT AGAAATAAATGATGATAAACTCTAACTAATAAAGGAAAGAGAATATTTGGTTACTCAGATCCATTTTTA ACCTCTGGTGCTGTATAAAGGGAATATTAAACTAGATGTAAATCAAAGTATATGTTTGGCTCATTTGAG CATTTTGGAATATTTGAGAATGTATGATACATGTAAAATTAAAAAAACTATTAGAACTGTACCATAATT ATGTTGAAGGTAGAAGTGATCTTCAAAGAGATGGCCATTAACTTAGCAGTGGGACCTCACTTTTACAAG CACTGCTCTAGATATACTTGAAGAATTTAATAGGTACAGAAGTTTATTCTGGATAATAAATAAATAAGG ATCACACTGTATTAGGGGTTATGGCAACATTATTGAATTTTTTATGTACATAAAGCCATATGTTTAGGG TGGTTTCTATCTGTCTTGTTTTTCACTTATATAACACTGTGAACTTCTAAAGCAAGAGGATAAAAGAAG CATGAATGAAAAGAATGACATTTCAAAAAAATGGTTCAATGAAAAACTATAGCTAAAATATGTAAACCT TTCTAGGTAAACCGCTTGCCTTCATCTTGAGTCGGAATATATTTAAATAAATTGTGTTATCTCTTGCCA AACATTTTGTTAGTGTTTATTTAAAAACAAAATGTTGTTTCTTAATGCATTTAAATCAGTTTTGTATTG TGCAGTAAAATGTGAGAAAATATAAACATTTCTATTGTATTTTAAATGTTAAAACACAAAAGTTCAATA AACCTTGAAGTTGATTAGTA ACGCGTAAGCGGCCGCGGCATCTAGATTCGAAGAAAATGACCGACCAAGCGACGCCCAACCTGCCATCA CGAGATTTCGATTCCACCGCCGCCTTCTATGAAAGG
Restriction Sites	SgfI-MluI
OTI Disclaimer	Our molecular clone sequence data has been matched to the sequence identifier above as a point of reference. Note that the complete sequence of this clone is largely the same as the reference sequence but may contain minor differences , e.g., single nucleotide polymorphisms (SNPs).
Reference Data
RefSeq	NM_003477.3
Synonyms	DLDBP; E3BP; OPDX; PDHXD; PDX1; proX
Summary	The pyruvate dehydrogenase (PDH) complex is located in the mitochondrial matrix and catalyzes the conversion of pyruvate to acetyl coenzyme A. The PDH complex thereby links glycolysis to Krebs cycle. The PDH complex contains three catalytic subunits, E1, E2, and E3, two regulatory subunits, E1 kinase and E1 phosphatase, and a non-catalytic subunit, E3 binding protein (E3BP). This gene encodes the E3 binding protein subunit; also known as component X of the pyruvate dehydrogenase complex. This protein tethers E3 dimers to the E2 core of the PDH complex. Defects in this gene are a cause of pyruvate dehydrogenase deficiency which results in neurological dysfunction and lactic acidosis in infancy and early childhood. This protein is also a minor antigen for antimitochondrial antibodies. These autoantibodies are present in nearly 95% of patients with the autoimmune liver disease primary biliary cirrhosis (PBC). In PBC, activated T lymphocytes attack and destroy epithelial cells in the bile duct where this protein is abnormally distributed and overexpressed. PBC eventually leads to cirrhosis and liver failure. Alternative splicing results in multiple transcript variants encoding distinct isoforms.[provided by RefSeq, Oct 2009]
Locus ID	8050
MW	38.5

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