PDHX (NM_001166158) Human 3' UTR Clone
CAT#: SC211369
3' UTR clone of pyruvate dehydrogenase complex component X (PDHX) nuclear gene encoding mitochondrial protein transcript variant 3 for miRNA target validation
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CNY 4,845.00
货期*
3周
规格
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经常一起买 (2)
Specifications
Product Data | |
Product Name | PDHX (NM_001166158) Human 3' UTR Clone |
Vector | pMirTarget |
Synonyms | DLDBP; E3BP; OPDX; PDHXD; PDX1; proX |
ACCN | NM_001166158 |
Insert Size | 986 bp |
Sequence Data |
>SC211369 3’UTR clone of NM_001166158
The sequence shown below is from the reference sequence of NM_001166158. The complete sequence of this clone may contain minor differences, such as SNPs. Blue=Stop Codon Red=Cloning site GGCAAGTTGGACGCCCGCAAGATCCGCGAGATTCTCATTAAGGCCAAGAAGGGCGGAAAGATCGCCGTG TAACAATTGGCAGAGCTCAGAATTCAAGCGATCGCC AACCTAGAGAATCCTATCCGACTTGCCTAGTCCTCAAAGATAAGAAGTTGGTGTTCAGCTTAGTTGATT CAGTAGTTGTTACCAAGAAACATATGTTATAGGAAAACAACTTGGTATTTAAGTATGAAGTGGATGAAA TGTTTATTTATTTAAGGTGAAAGCATTTGACCCAGGGTGTCTTCATCTTCAATTTGGGTTTAATGTTAT AGAAATAAATGATGATAAACTCTAACTAATAAAGGAAAGAGAATATTTGGTTACTCAGATCCATTTTTA ACCTCTGGTGCTGTATAAAGGGAATATTAAACTAGATGTAAATCAAAGTATATGTTTGGCTCATTTGAG CATTTTGGAATATTTGAGAATGTATGATACATGTAAAATTAAAAAAACTATTAGAACTGTACCATAATT ATGTTGAAGGTAGAAGTGATCTTCAAAGAGATGGCCATTAACTTAGCAGTGGGACCTCACTTTTACAAG CACTGCTCTAGATATACTTGAAGAATTTAATAGGTACAGAAGTTTATTCTGGATAATAAATAAATAAGG ATCACACTGTATTAGGGGTTATGGCAACATTATTGAATTTTTTATGTACATAAAGCCATATGTTTAGGG TGGTTTCTATCTGTCTTGTTTTTCACTTATATAACACTGTGAACTTCTAAAGCAAGAGGATAAAAGAAG CATGAATGAAAAGAATGACATTTCAAAAAAATGGTTCAATGAAAAACTATAGCTAAAATATGTAAACCT TTCTAGGTAAACCGCTTGCCTTCATCTTGAGTCGGAATATATTTAAATAAATTGTGTTATCTCTTGCCA AACATTTTGTTAGTGTTTATTTAAAAACAAAATGTTGTTTCTTAATGCATTTAAATCAGTTTTGTATTG TGCAGTAAAATGTGAGAAAATATAAACATTTCTATTGTATTTTAAATGTTAAAACACAAAAGTTCAATA AACCTTGAAGTTGATTAGTA ACGCGTAAGCGGCCGCGGCATCTAGATTCGAAGAAAATGACCGACCAAGCGACGCCCAACCTGCCATCA CGAGATTTCGATTCCACCGCCGCCTTCTATGAAAGG |
Restriction Sites | SgfI-MluI |
OTI Disclaimer | Our molecular clone sequence data has been matched to the sequence identifier above as a point of reference. Note that the complete sequence of this clone is largely the same as the reference sequence but may contain minor differences , e.g., single nucleotide polymorphisms (SNPs). |
Reference Data | |
RefSeq | NM_001166158.2 |
Synonyms | DLDBP; E3BP; OPDX; PDHXD; PDX1; proX |
Summary | The pyruvate dehydrogenase (PDH) complex is located in the mitochondrial matrix and catalyzes the conversion of pyruvate to acetyl coenzyme A. The PDH complex thereby links glycolysis to Krebs cycle. The PDH complex contains three catalytic subunits, E1, E2, and E3, two regulatory subunits, E1 kinase and E1 phosphatase, and a non-catalytic subunit, E3 binding protein (E3BP). This gene encodes the E3 binding protein subunit; also known as component X of the pyruvate dehydrogenase complex. This protein tethers E3 dimers to the E2 core of the PDH complex. Defects in this gene are a cause of pyruvate dehydrogenase deficiency which results in neurological dysfunction and lactic acidosis in infancy and early childhood. This protein is also a minor antigen for antimitochondrial antibodies. These autoantibodies are present in nearly 95% of patients with the autoimmune liver disease primary biliary cirrhosis (PBC). In PBC, activated T lymphocytes attack and destroy epithelial cells in the bile duct where this protein is abnormally distributed and overexpressed. PBC eventually leads to cirrhosis and liver failure. Alternative splicing results in multiple transcript variants encoding distinct isoforms.[provided by RefSeq, Oct 2009] |
Locus ID | 8050 |
MW | 38.5 |
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