BRCA2 (NM_000059) Human 3' UTR Clone

Specifications

Product Data
Product Name	BRCA2 (NM_000059) Human 3' UTR Clone
Vector	pMirTarget
Synonyms	BRCC2; BROVCA2; FACD; FAD; FAD1; FANCD; FANCD1; GLM3; PNCA2; XRCC11
ACCN	NM_000059
Insert Size	1528 bp
Sequence Data	Insert Sequence (showhide) >SC210971 3’UTR clone of NM_000059 The sequence shown below is from the reference sequence of NM_000059. The complete sequence of this clone may contain minor differences, such as SNPs. Blue=Stop Codon Red=Cloning site GGCAAGTTGGACGCCCGCAAGATCCGCGAGATTCTCATTAAGGCCAAGAAGGGCGGAAAGATCGCCGTG TAACAATTGGCAGAGCTCAGAATTCAAGCGATCGCC GACACAATTACAACTAAAAAATATATCTAAGCATTTGCAAAGGCGACAATAAATTATTGACGCTTAACC TTTCCAGTTTATAAGACTGGAATATAATTTCAAACCACACATTAGTACTTATGTTGCACAATGAGAAAA GAAATTAGTTTCAAATTTACCTCAGCGTTTGTGTATCGGGCAAAAATCGTTTTGCCCGATTCCGTATTG GTATACTTTTGCTTCAGTTGCATATCTTAAAACTAAATGTAATTTATTAACTAATCAAGAAAAACATCT TTGGCTGAGCTCGGTGGCTCATGCCTGTAATCCCAACACTTTGAGAAGCTGAGGTGGGAGGAGTGCTTG AGGCCAGGAGTTCAAGACCAGCCTGGGCAACATAGGGAGACCCCCATCTTTACAAAGAAAAAAAAAAGG GGAAAAGAAAATCTTTTAAATCTTTGGATTTGATCACTACAAGTATTATTTTACAAGTGAAATAAACAT ACCATTTTCTTTTAGATTGTGTCATTAAATGGAATGAGGTCTCTTAGTACAGTTATTTTGATGCAGATA ATTCCTTTTAGTTTAGCTACTATTTTAGGGGATTTTTTTTAGAGGTAACTCACTATGAAATAGTTCTCC TTAATGCAAATATGTTGGTTCTGCTATAGTTCCATCCTGTTCAAAAGTCAGGATGAATATGAAGAGTGG TGTTTCCTTTTGAGCAATTCTTCATCCTTAAGTCAGCATGATTATAAGAAAAATAGAACCCTCAGTGTA ACTCTAATTCCTTTTTACTATTCCAGTGTGATCTCTGAAATTAAATTACTTCAACTAAAAATTCAAATA CTTTAAATCAGAAGATTTCATAGTTAATTTATTTTTTTTTTCAACAAAATGGTCATCCAAACTCAAACT TGAGAAAATATCTTGCTTTCAAATTGGCACTGATTCTGCCTGCTTTATTTTTAGCGCTATCACAGGACC CAGAGCCTATGCCCTTTTAAACTTACCACAAAAGCAGAAGATTAATTCAATTTAAGATGATACTCTCAT TTGTTACGTCCTTTTTTTTTTTTTTTGGAGATGGAGTCTTGCTTTGTCGCCCATGCTGGAGTGCAGTGG CATGATCCTGGCTCACTGCAGCCTCCACTTCCCGGGTTCACGTAATTCTCCCACCTCAAGCCTCCCTAG TAGCTGGGATTACAGGGACGCACCACCATGCCCAGCTAATTTTTGCATTTTTAGTAGAGACTGGGTTTT ACCATGTTGGCCAAGCTGGTCTCAAACTCCTGATGTCAGGTGATCCATCTGCCTCAGCCTCCCAAAGTG CTGGGATTATAGGCGTGAGCCACTGTGCCCGGCCAATATTTGTTACTTTCTTAGGTTTAATAGAGAAAA GGGATAAAACATTTCTAACTGGGAGTTAATTGCATGGAGAAGGTCTTAAATCAGATGTTTTAATGCCTT AAATGTCTGTATAATATCATGTTTTCAAATCTAATTATAAATACGTTTAAAGCCAAGAATAAATCTTTT AAAAAATTGA ACGCGTAAGCGGCCGCGGCATCTAGATTCGAAGAAAATGACCGACCAAGCGACGCCCAACCTGCCATCA CGAGATTTCGATTCCACCGCCGCCTTCTATGAAAGG
Restriction Sites	SgfI-MluI
OTI Disclaimer	Our molecular clone sequence data has been matched to the sequence identifier above as a point of reference. Note that the complete sequence of this clone is largely the same as the reference sequence but may contain minor differences , e.g., single nucleotide polymorphisms (SNPs).
Reference Data
RefSeq	NM_000059.4
Synonyms	BRCC2; BROVCA2; FACD; FAD; FAD1; FANCD; FANCD1; GLM3; PNCA2; XRCC11
Summary	Inherited mutations in BRCA1 and this gene, BRCA2, confer increased lifetime risk of developing breast or ovarian cancer. Both BRCA1 and BRCA2 are involved in maintenance of genome stability, specifically the homologous recombination pathway for double-strand DNA repair. The largest exon in both genes is exon 11, which harbors the most important and frequent mutations in breast cancer patients. The BRCA2 gene was found on chromosome 13q12.3 in human. The BRCA2 protein contains several copies of a 70 aa motif called the BRC motif, and these motifs mediate binding to the RAD51 recombinase which functions in DNA repair. BRCA2 is considered a tumor suppressor gene, as tumors with BRCA2 mutations generally exhibit loss of heterozygosity (LOH) of the wild-type allele. [provided by RefSeq, May 2020]
Locus ID	675
MW	59.5

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