DDIT4 (NM_019058) Human 3' UTR Clone

Specifications

Product Data
Product Name	DDIT4 (NM_019058) Human 3' UTR Clone
Vector	pMirTarget
Synonyms	Dig2; REDD-1; REDD1
ACCN	NM_019058
Insert Size	878 bp
Sequence Data	Insert Sequence (showhide) >SC210461 3’UTR clone of NM_019058 The sequence shown below is from the reference sequence of NM_019058. The complete sequence of this clone may contain minor differences, such as SNPs. Blue=Stop Codon Red=Cloning site GGCAAGTTGGACGCCCGCAAGATCCGCGAGATTCTCATTAAGGCCAAGAAGGGCGGAAAGATCGCCGTG TAACAATTGGCAGAGCTCAGAATTCAAGCGATCGCC TCGGAACAGCTGCTCATTGAGGAGTGTTGAACTTCAACCTGAGGGGGCCGACAGTGCCCTCCAAGACAG AGACGACTGAACTTTTGGGGTGGAGACTAGAGGCAGGAGCTGAGGGACTGATTCCTGTGGTTGGAAAAC TGAGGCAGCCACCTAAGGTGGAGGTGGGGGAATAGTGTTTCCCAGGAAGCTCATTGAGTTGTGTGCGGG TGGCTGTGCATTGGGGACACATACCCCTCAGTACTGTAGCATGAAACAAAGGCTTAGGGGCCAACAAGG CTTCCAGCTGGATGTGTGTGTAGCATGTACCTTATTATTTTTGTTACTGACAGTTAACAGTGGTGTGAC ATCCAGAGAGCAGCTGGGCTGCTCCCGCCCCAGCCCGGCCCAGGGTGAAGGAAGAGGCACGTGCTCCTC AGAGCAGCCGGAGGGAGGGGGGAGGTCGGAGGTCGTGGAGGTGGTTTGTGTATCTTACTGGTCTGAAGG GACCAAGTGTGTTTGTTGTTTGTTTTGTATCTTGTTTTTCTGATCGGAGCATCACTACTGACCTGTTGT AGGCAGCTATCTTACAGACGCATGAATGTAAGAGTAGGAAGGGGTGGGTGTCAGGGATCACTTGGGATC TTTGACACTTGAAAAATTACACCTGGCAGCTGCGTTTAAGCCTTCCCCCATCGTGTACTGCAGAGTTGA GCTGGCAGGGGAGGGGCTGAGAGGGTGGGGGCTGGAACCCCTCCCCGGGAGGAGTGCCATCTGGGTCTT CCATCTAGAACTGTTTACATGAAGATAAGATACTCACTGTTCATGAATACACTTGATGTTCAAGTATTA AGACCTATGCAATATTTTTTACTTTTCTAATAAACATGTTTGTTAAAACA ACGCGTAAGCGGCCGCGGCATCTAGATTCGAAGAAAATGACCGACCAAGCGACGCCCAACCTGCCATCA CGAGATTTCGATTCCACCGCCGCCTTCTATGAAAGG
Restriction Sites	SgfI-MluI
OTI Disclaimer	Our molecular clone sequence data has been matched to the sequence identifier above as a point of reference. Note that the complete sequence of this clone is largely the same as the reference sequence but may contain minor differences , e.g., single nucleotide polymorphisms (SNPs).
Reference Data
RefSeq	NM_019058.4
Synonyms	Dig2; REDD-1; REDD1
Summary	Regulates cell growth, proliferation and survival via inhibition of the activity of the mammalian target of rapamycin complex 1 (mTORC1). Inhibition of mTORC1 is mediated by a pathway that involves DDIT4/REDD1, AKT1, the TSC1-TSC2 complex and the GTPase RHEB. Plays an important role in responses to cellular energy levels and cellular stress, including responses to hypoxia and DNA damage. Regulates p53/TP53-mediated apoptosis in response to DNA damage via its effect on mTORC1 activity. Its role in the response to hypoxia depends on the cell type; it mediates mTORC1 inhibition in fibroblasts and thymocytes, but not in hepatocytes (By similarity). Required for mTORC1-mediated defense against viral protein synthesis and virus replication (By similarity). Inhibits neuronal differentiation and neurite outgrowth mediated by NGF via its effect on mTORC1 activity. Required for normal neuron migration during embryonic brain development. Plays a role in neuronal cell death.[UniProtKB/Swiss-Prot Function]
Locus ID	54541
MW	32.6

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