ASK1 (MAP3K5) (NM_005923) Human 3' UTR Clone

Specifications

Product Data
Product Name	ASK1 (MAP3K5) (NM_005923) Human 3' UTR Clone
Vector	pMirTarget
Synonyms	ASK1; MAPKKK5; MEKK5
ACCN	NM_005923
Insert Size	742 bp
Sequence Data	Insert Sequence (showhide) >SC209333 3’UTR clone of NM_005923 The sequence shown below is from the reference sequence of NM_005923. The complete sequence of this clone may contain minor differences, such as SNPs. Blue=Stop Codon Red=Cloning site GGCAAGTTGGACGCCCGCAAGATCCGCGAGATTCTCATTAAGGCCAAGAAGGGCGGAAAGATCGCCGTG TAACAATTGGCAGAGCTCAGAATTCAAGCGATCGCC ATCATTGACTTTCGAAACAAACAGACTTGACTGTTGCTCAATCTAATCTTCGATGGAAATTCTAAAAAT TAATACAGAGCTGATCTTCTTGGGGGTGGGAAAATCGAAGGGAGAGGAGAAAGGCGCTGCACTTTAAAT CCAGTATTTGTTTACTCATGTTAAAAAAAAAAAAAACAGACAAAACACACTGAAATTTCCTAACTACAT CTATTTCTATAATTTTTAAGGACTCTTCATAAGGACTCTTAAAATAATCCTGAACATTAGAACCCTAAT GTTCAGGAAGATTTTAATCTAAGCATTTTTATGGAAATATTTTTAATGCAGCAGCTATTGCACTTCAGC CAAATGTTTATTTCACACAAAACGGATGTAACATTTCATGTGATCGTGCACCACTGGAACAAAACCAAA ATGTGACCATAACTGTTTAGGCTTCTGTGTGTTTGTAATATGCTCTAATAATCTGAGTAGAAATGCGTA ATTTCAATTACTGTATAAAGTTTATGTTTTTTTAAGTGTGCAGAATCTGAGAGCAATGGTTTTTACTTC TCTGTGTTAATTGTAATATTGACTCTATTTTGTAACTTAAGTTTCTGACCTGTCGTACATTTGTTTGAG TCGTTTATGTACTACTGAACTGTACCAGTTGCACATGCTTGAACTGTAGTAATGTTAGCTTGTTCTAAA GCTATCCATTGTGTCATATTTACTCTAAAAATTAAAGAGACTCTCAACATAC ACGCGTAAGCGGCCGCGGCATCTAGATTCGAAGAAAATGACCGACCAAGCGACGCCCAACCTGCCATCA CGAGATTTCGATTCCACCGCCGCCTTCTATGAAAGG
Restriction Sites	SgfI-MluI
OTI Disclaimer	Our molecular clone sequence data has been matched to the sequence identifier above as a point of reference. Note that the complete sequence of this clone is largely the same as the reference sequence but may contain minor differences , e.g., single nucleotide polymorphisms (SNPs).
Reference Data
RefSeq	NM_005923.4
Synonyms	ASK1; MAPKKK5; MEKK5
Summary	Mitogen-activated protein kinase (MAPK) signaling cascades include MAPK or extracellular signal-regulated kinase (ERK), MAPK kinase (MKK or MEK), and MAPK kinase kinase (MAPKKK or MEKK). MAPKK kinase/MEKK phosphorylates and activates its downstream protein kinase, MAPK kinase/MEK, which in turn activates MAPK. The kinases of these signaling cascades are highly conserved, and homologs exist in yeast, Drosophila, and mammalian cells. MAPKKK5 contains 1,374 amino acids with all 11 kinase subdomains. Northern blot analysis shows that MAPKKK5 transcript is abundantly expressed in human heart and pancreas. The MAPKKK5 protein phosphorylates and activates MKK4 (aliases SERK1, MAPKK4) in vitro, and activates c-Jun N-terminal kinase (JNK)/stress-activated protein kinase (SAPK) during transient expression in COS and 293 cells; MAPKKK5 does not activate MAPK/ERK. [provided by RefSeq, Jul 2008]
Locus ID	4217
MW	28.7

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