PIP5K3 (PIKFYVE) (NM_152671) Human 3' UTR Clone

Specifications

Product Data
Product Name	PIP5K3 (PIKFYVE) (NM_152671) Human 3' UTR Clone
Vector	pMirTarget
Synonyms	CFD; FAB1; HEL37; PIP5K; PIP5K3; ZFYVE29
ACCN	NM_152671
Insert Size	555 bp
Sequence Data	Insert Sequence (showhide) >SC208150 3’UTR clone of NM_152671 The sequence shown below is from the reference sequence of NM_152671. The complete sequence of this clone may contain minor differences, such as SNPs. Blue=Stop Codon Red=Cloning site GGCAAGTTGGACGCCCGCAAGATCCGCGAGATTCTCATTAAGGCCAAGAAGGGCGGAAAGATCGCCGTG TAACAATTGGCAGAGCTCAGAATTCAAGCGATCGCC CACCCTGCTGACCAAAAAGGTAGGAGGTAGTCACCATCTGGAATCCAAACACAGGCTGGACAGCTGGGC CATAGGATCTCATGCCAGCCTGTCCTTCTGGCTTCCTCTGTCCCACGTGGCTGAGGGTATTTGGTGTGG GTTTTGTTCTACCCTTTCTCATTTCTCCCACACCTCCTCCCCATACCTTTTTTGGTTGATTCCTTTTAT TTCTTGTTTTCTCCCTCAGCACCACCATGCCCAGTGTAAAGCTTGTAGTCTTTAAAAGGAACTACATCT GACTGCTCTTCCCATAATGTGCAACTTCCAAGGTGGCATTTCTTTGCATTTATAACATGGATGTTCTGC TCTATTCTTTTCTCTTTCTTCATTTAACATTTTAAAGCCTATTTGCCTTTGCCGTTACCCAGTAACATA ATATTTCACTAAACCCATTAAGATGCTTGAACTAGATTGGGGGAAAATCATTCACACATTCCAAAATAT CTCCATAATAATTCATAATGCTTATTATGTATATTCTATATTTATTAAAACAATTTCTTCTCTAATGTA AAA ACGCGTAAGCGGCCGCGGCATCTAGATTCGAAGAAAATGACCGACCAAGCGACGCCCAACCTGCCATCA CGAGATTTCGATTCCACCGCCGCCTTCTATGAAAGG
Restriction Sites	SgfI-MluI
OTI Disclaimer	Our molecular clone sequence data has been matched to the sequence identifier above as a point of reference. Note that the complete sequence of this clone is largely the same as the reference sequence but may contain minor differences , e.g., single nucleotide polymorphisms (SNPs).
Reference Data
RefSeq	NM_152671.4
Synonyms	CFD; FAB1; HEL37; PIP5K; PIP5K3; ZFYVE29
Summary	Phosphorylated derivatives of phosphatidylinositol (PtdIns) regulate cytoskeletal functions, membrane trafficking, and receptor signaling by recruiting protein complexes to cell- and endosomal-membranes. Humans have multiple PtdIns proteins that differ by the degree and position of phosphorylation of the inositol ring. This gene encodes an enzyme (PIKfyve; also known as phosphatidylinositol-3-phosphate 5-kinase type III or PIPKIII) that phosphorylates the D-5 position in PtdIns and phosphatidylinositol-3-phosphate (PtdIns3P) to make PtdIns5P and PtdIns(3,5)biphosphate. The D-5 position also can be phosphorylated by type I PtdIns4P-5-kinases (PIP5Ks) that are encoded by distinct genes and preferentially phosphorylate D-4 phosphorylated PtdIns. In contrast, PIKfyve preferentially phosphorylates D-3 phosphorylated PtdIns. In addition to being a lipid kinase, PIKfyve also has protein kinase activity. PIKfyve regulates endomembrane homeostasis and plays a role in the biogenesis of endosome carrier vesicles from early endosomes. Mutations in this gene cause corneal fleck dystrophy (CFD); an autosomal dominant disorder characterized by numerous small white flecks present in all layers of the corneal stroma. Histologically, these flecks appear to be keratocytes distended with lipid and mucopolysaccharide filled intracytoplasmic vacuoles. Alternative splicing results in multiple transcript variants encoding distinct isoforms.[provided by RefSeq, May 2010]
Locus ID	200576
MW	21.2

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