NISCH (NM_007184) Human 3' UTR Clone

Specifications

Product Data
Product Name	NISCH (NM_007184) Human 3' UTR Clone
Vector	pMirTarget
Synonyms	hIRAS; I-1; IR1; IRAS
ACCN	NM_007184
Insert Size	616 bp
Sequence Data	Insert Sequence (showhide) >SC207984 3’UTR clone of NM_007184 The sequence shown below is from the reference sequence of NM_007184. The complete sequence of this clone may contain minor differences, such as SNPs. Blue=Stop Codon Red=Cloning site GGCAAGTTGGACGCCCGCAAGATCCGCGAGATTCTCATTAAGGCCAAGAAGGGCGGAAAGATCGCCGTG TAACAATTGGCAGAGCTCAGAATTCAAGCGATCGCC CGTGAGCTGCCTGTCGAGCTCACCGGCTAGCCCAGGCCACAGCCAGCCTGTCGTGTCCAGCCTGACGCC TACTGGGGCAGGGCAGCAGGCTTTTGTGTTCTCTAAAAATGTTTTATCCTCCCTTTGGTACCTTAATTT GACTGTCCTCGCAGAGAATGTGAACATGTGTGTGTGTTGTGTTAATTCTTTCTCATGTTGGGAGTGAGA ATGCCGGGCCCCTCAGGGCTGTCGGTGTGCTGTCAGCCTCCCACAGGTGGTACAGCCGTGCACACCAGT GTCGTGTCTGCTGTTGTGGGACCGTTGTTAACACGTGACACTGTGGGTCTGACTTTCTCTTCTACACGT CCTTTCCTGAAGTGTCGAGTCCAGTCCTTTGTTGCTGTTGCTGTTGCTGTTGCTGTTGCTGTTGCTGTT GGCATCTTGCTGCTAATCCTGAGGCTGGTAGCAGAATGCACATTGGAAGCTCCCACCCCATATTGTTCT TCAAAGTGGAGGTCTCCCCTGATCCAGACAAGTGGGAGAGCCCGTGGGGGCAGGGGACCTGGAGCTGCC AGCACCAAGCGTGATTCCTGCTGCCTGTATTCTCTATTCCAATAAAGCAGAGTTTGACACCGTC ACGCGTAAGCGGCCGCGGCATCTAGATTCGAAGAAAATGACCGACCAAGCGACGCCCAACCTGCCATCA CGAGATTTCGATTCCACCGCCGCCTTCTATGAAAGG
Restriction Sites	SgfI-MluI
OTI Disclaimer	Our molecular clone sequence data has been matched to the sequence identifier above as a point of reference. Note that the complete sequence of this clone is largely the same as the reference sequence but may contain minor differences , e.g., single nucleotide polymorphisms (SNPs).
Reference Data
RefSeq	NM_007184.4
Synonyms	hIRAS; I-1; IR1; IRAS
Summary	This gene encodes a nonadrenergic imidazoline-1 receptor protein that localizes to the cytosol and anchors to the inner layer of the plasma membrane. The orthologous mouse protein has been shown to influence cytoskeletal organization and cell migration by binding to alpha-5-beta-1 integrin. In humans, this protein has been shown to bind to the adapter insulin receptor substrate 4 (IRS4) to mediate translocation of alpha-5 integrin from the cell membrane to endosomes. Expression of this protein was reduced in human breast cancers while its overexpression reduced tumor growth and metastasis; possibly by limiting the expression of alpha-5 integrin. In human cardiac tissue, this gene was found to affect cell growth and death while in neural tissue it affected neuronal growth and differentiation. Alternative splicing results in multiple transcript variants encoding differerent isoforms. Some isoforms lack the expected C-terminal domains of a functional imidazoline receptor. [provided by RefSeq, Jan 2013]
Locus ID	11188
MW	22.1

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