Corticotropin Releasing Factor (CRH) (NM_000756) Human 3' UTR Clone

Specifications

Product Data
Product Name	Corticotropin Releasing Factor (CRH) (NM_000756) Human 3' UTR Clone
Vector	pMirTarget
Synonyms	CRF; CRH1
ACCN	NM_000756
Insert Size	541 bp
Sequence Data	Insert Sequence (showhide) >SC206875 3’UTR clone of NM_000756 The sequence shown below is from the reference sequence of NM_000756. The complete sequence of this clone may contain minor differences, such as SNPs. Blue=Stop Codon Red=Cloning site GGCAAGTTGGACGCCCGCAAGATCCGCGAGATTCTCATTAAGGCCAAGAAGGGCGGAAAGATCGCCGTG TAACAATTGGCAGAGCTCAGAATTCAAGCGATCGCC AGGAAACTCATGGAGATTATTGGGAAATAAAACGGTGCGTTTGGCCAAAAAGAATCTGCATTTAGCACA AAAAAAATTTAAAAAAATACAGTATTCTGTACCATAGCGCTGCTCTTATGCCATTTGTTTATTTTTATA TAGCTTGAAACATAGAGGGAGAGAGGGAGAGAGCCTATACCCCTTACTTAGCATGCACAAAGTGTATTC ACGTGCAGCAGCAACACAATGTTATTCGTTTTGTCTACGTTTAGTTTCCGTTTCCAGGTGTTTATAGTG GTGTTTTAAAGAGAATGTAGACCTGTGAGAAAACGTTTTGTTTGAAAAAGCAGACAGAAGTCACTCAAT TGTTTTTGTTGTGGTCTGAGCCAAAGAGAATGCCATTCTCTTGGGTGGGTAAGACTAAATCTGTAAGCT CTTTGAAACAACTTTCTCTTGTAAACGTTTCAGTAATAAAACATCTTTCCAGTCCTTGGTCAGTTTGGT TGTGTAAGAGAATGTTGAATACTTATATTTTTAATAAAAGTTGCAAAGGTAATCATGA ACGCGTAAGCGGCCGCGGCATCTAGATTCGAAGAAAATGACCGACCAAGCGACGCCCAACCTGCCATCA CGAGATTTCGATTCCACCGCCGCCTTCTATGAAAGG
Restriction Sites	SgfI-MluI
OTI Disclaimer	Our molecular clone sequence data has been matched to the sequence identifier above as a point of reference. Note that the complete sequence of this clone is largely the same as the reference sequence but may contain minor differences , e.g., single nucleotide polymorphisms (SNPs).
Reference Data
RefSeq	NM_000756.4
Synonyms	CRF; CRH1
Summary	This gene encodes a member of the corticotropin-releasing factor family. The encoded preproprotein is proteolytically processed to generate the mature neuropeptide hormone. In response to stress, this hormone is secreted by the paraventricular nucleus (PVN) of the hypothalamus, binds to corticotropin releasing hormone receptors and stimulates the release of adrenocorticotropic hormone from the pituitary gland. Marked reduction in this protein has been observed in association with Alzheimer's disease. Autosomal recessive hypothalamic corticotropin deficiency has multiple and potentially fatal metabolic consequences including hypoglycemia and hepatitis. In addition to production in the hypothalamus, this protein is also synthesized in peripheral tissues, such as T lymphocytes, and is highly expressed in the placenta. In the placenta it is a marker that determines the length of gestation and the timing of parturition and delivery. A rapid increase in circulating levels of the hormone occurs at the onset of parturition, suggesting that, in addition to its metabolic functions, this protein may act as a trigger for parturition. [provided by RefSeq, Nov 2015]
Locus ID	1392
MW	20.8

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