HSPA2 (NM_021979) Human 3' UTR Clone

Specifications

Product Data
Product Name	HSPA2 (NM_021979) Human 3' UTR Clone
Vector	pMirTarget
Synonyms	HSP70-2; HSP70-3
ACCN	NM_021979
Insert Size	498 bp
Sequence Data	Insert Sequence (showhide) >SC206748 3’UTR clone of NM_021979 The sequence shown below is from the reference sequence of NM_021979. The complete sequence of this clone may contain minor differences, such as SNPs. Blue=Stop Codon Red=Cloning site GGCAAGTTGGACGCCCGCAAGATCCGCGAGATTCTCATTAAGGCCAAGAAGGGCGGAAAGATCGCCGTG TAACAATTGGCAGAGCTCAGAATTCAAGCGATCGCC GGGGGACCCACCATCGAAGAAGTGGACTAAGCTTGCACTCAAGTCAGCGTAAACCTCTTTGCCTTTCTC TCTCTCTCTTTTTTTTTGTTTGTTTCTTTGAAATGTCCTTGTGCCAAGTACGAGATCTATTGTTGGAAG TCTTTGGTATATGCAAATGAAAGGAGAGGTGCAACAACTTAGTTTAATTATAAAAGTTCCAAAGTTTGT TTTTTAAAAACATTATTCGAGGTTTCTCTTTAATGCATTTTGCGTGTTTGCTGACTTGAGCATTTTTGA TTAGTTCGTGCATGGAGATTTGTTTGAGATGAGAAACCTTAAGTTTGCACACCTGTTCTGTAGAAGCTT GGAAACAGTAAAATATATAGGAGCTTAAATTGTTTATTTTTATGTACTACTTTAAAACTAAACTGAACA TTGCAGTAATGTTAAGGACAGGTATACTTTTTGCAAACAAATGCATAAATGCAAATGTAAAGTAAAGCT GAAATTGATCTCAAA ACGCGTAAGCGGCCGCGGCATCTAGATTCGAAGAAAATGACCGACCAAGCGACGCCCAACCTGCCATCA CGAGATTTCGATTCCACCGCCGCCTTCTATGAAAGG
Restriction Sites	SgfI-MluI
OTI Disclaimer	Our molecular clone sequence data has been matched to the sequence identifier above as a point of reference. Note that the complete sequence of this clone is largely the same as the reference sequence but may contain minor differences , e.g., single nucleotide polymorphisms (SNPs).
Reference Data
RefSeq	NM_021979.4
Synonyms	HSP70-2; HSP70-3
Summary	Molecular chaperone implicated in a wide variety of cellular processes, including protection of the proteome from stress, folding and transport of newly synthesized polypeptides, activation of proteolysis of misfolded proteins and the formation and dissociation of protein complexes. Plays a pivotal role in the protein quality control system, ensuring the correct folding of proteins, the re-folding of misfolded proteins and controlling the targeting of proteins for subsequent degradation. This is achieved through cycles of ATP binding, ATP hydrolysis and ADP release, mediated by co-chaperones. The affinity for polypeptides is regulated by its nucleotide bound state. In the ATP-bound form, it has a low affinity for substrate proteins. However, upon hydrolysis of the ATP to ADP, it undergoes a conformational change that increases its affinity for substrate proteins. It goes through repeated cycles of ATP hydrolysis and nucleotide exchange, which permits cycles of substrate binding and release (PubMed:26865365). Plays a role in spermatogenesis. In association with SHCBP1L may participate in the maintenance of spindle integrity during meiosis in male germ cells (By similarity).[UniProtKB/Swiss-Prot Function]
Locus ID	3306
MW	19.1

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