Leptin Receptor (LEPR) (NM_002303) Human 3' UTR Clone

Specifications

Product Data
Product Name	Leptin Receptor (LEPR) (NM_002303) Human 3' UTR Clone
Vector	pMirTarget
Synonyms	CD295; LEP-R; LEPRD; OB-R; OBR
ACCN	NM_002303
Insert Size	484 bp
Sequence Data	Insert Sequence (showhide) >SC206473 3' UTR clone of NM_002303 The sequence shown below is from the reference sequence of NM_002303. The complete sequence of this clone may contain minor differences, such as SNPs. Red=Cloning site Blue=Stop Codon CAATTGGCAGAGCTCAGAATTCAAGCGATCGC GGAAAACAAGATGTGTGACCTAACTGTGTAATTTCACTGAAGAAACCTTCAGATTTGTGTTATAATGGGT AATATAAAGTGTAATAGATTATAGTTGTGGGTGGGAGAGAGAAAAGAAACCAGAGTCAAATTTGAAAATA ATTGTTCCAAATGAATGTTGTCTGTTTGTTCTCTCTTAGTAACATAGACAAAAAATTTGAGAAAGCCTTC ATAAGCCTACCAATGTAGACACGCTCTTCTATTTTATTCCCAAGCTCTAGTGGGAAGGTCCCTTGTTTCC AGCTAGAAATAAGCCCAACAGACACCATCTTTTGTGAGATGTAATTGTTTTTTCAGAGGGCGTGTTGTTT TACCTCAAGTTTTTGTTTTGTACCAACACACACACACACACACATTCTTAACACATGTCCTTGTGTGTTT TGAGAGTATATTATGTATTTATATTTTGTGCTATCAGACTGTAGGATTTGAAGTAGGACTTTCC ACGCGTAAGCGGCCGCGGCATCTAGATTCGAAGAAAATGACCG
Restriction Sites	SgfI-MluI
OTI Disclaimer	Our molecular clone sequence data has been matched to the sequence identifier above as a point of reference. Note that the complete sequence of this clone is largely the same as the reference sequence but may contain minor differences , e.g., single nucleotide polymorphisms (SNPs).
Reference Data
RefSeq	NM_002303.4
Synonyms	CD295; LEP-R; LEPRD; OB-R; OBR
Summary	The protein encoded by this gene belongs to the gp130 family of cytokine receptors that are known to stimulate gene transcription via activation of cytosolic STAT proteins. This protein is a receptor for leptin (an adipocyte-specific hormone that regulates body weight), and is involved in the regulation of fat metabolism, as well as in a novel hematopoietic pathway that is required for normal lymphopoiesis. Mutations in this gene have been associated with obesity and pituitary dysfunction. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. It is noteworthy that this gene and LEPROT gene (GeneID:54741) share the same promoter and the first 2 exons, however, encode distinct proteins (PMID:9207021).[provided by RefSeq, Nov 2010]
Locus ID	3953

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