Bestrophin (BEST1) (NM_001139443) Human 3' UTR Clone

Specifications

Product Data
Product Name	Bestrophin (BEST1) (NM_001139443) Human 3' UTR Clone
Vector	pMirTarget
Synonyms	ARB; BEST; Best1V1Delta2; BMD; RP50; TU15B; VMD2
ACCN	NM_001139443
Insert Size	2000 bp
Sequence Data	Insert Sequence (showhide) >SC206279 3’UTR clone of NM_001139443 The sequence shown below is from the reference sequence of NM_001139443. The complete sequence of this clone may contain minor differences, such as SNPs. Blue=Stop Codon Red=Cloning site GGCAAGTTGGACGCCCGCAAGATCCGCGAGATTCTCATTAAGGCCAAGAAGGGCGGAAAGATCGCCGTG TAACAATTGGCAGAGCTCAGAATTCAAGCGATCGCC GACTTCTTGGGACCAGGTGAAGGAAGATGAGGTTGTGCTGACCAGAATGCTGCTGGAGAACTGCCCCAG GGCTGACAGGCCAGGCTTAGCTGAGCAGATGTTATCACTGGCCCCAACTTACTTTGAGCAAGGGTGGCT GACCCAAAACCATGAGGTGGCAGTCAGCTGGATGACAGATGAACACTTCCCCCATAACTATTTAGGGTA GTACCCAAGCACTACAGGAAAGGGTGGCAGGAACTGCCTCACTCCTAGGAACTGGTAGATGGTGAGGTT GAGGGTGTCCAGCGCCCTTAGGTCATTTTCTCACTGCCTGGGAACCTCACCAAAATACTTCTTGCTTCC TTGGGGTCAGCCCAAAGCTGTCACAAAATCAGATATTTCCCTTTATTCCAGATTTCCTGGACACTTTCA CCCAATTATAAACACCCCACTTCAGCCCCAATCACGTGGGAGGAAGTGTAACTTCCCTTTTCTGGATTC TCAAGCAGTTACTTTCACGGTCAGAACACGCAGCTATTATGATTGAAAACTTAAAAGGGCAACAATTTC AGTCTTGCTTCTAGGGCTAGACAGGAACTTGGCAAACATCTGTGGCCTGTTCAGCAAAGGATGTTAATA TTTAAGAATCTTGTCTTGGGCTGGGTGTGGAGGCAAGTGGATCACAGGAGGTCAGGAGTTTGAGACCAA CCTGGCCAACATGATGAAACCCCATCTCTACCAAAAAAAATACAAATCAGCTGGGCGTCGTGGTGTGCC TGTAGTCCCAACGCAGGAGGTTGAGGGGAGAATTGCTTGAACCCAGGAGGTGGTGGTTGCAGTGAGATT GAGCAACTGCAATCCAGCCTGGGCGACGGAGTGAGACTGTCTCAAAAAAAAAAAAAAAAGGATCGTCTC AACCTTTGCCCTCCTACTGCAACATTTTGGTATTTGAAATGAAGGGACCTTCCATACTTATGCTGTTAA TACTTTCATTCTCACTAGGGATGAAGCACATTCCTAACCTGCTTCCTAATGGGGATGCTTCGCCAGCCA GGTCCTCACCTGTGTGTACACCAGCAGGACACTGATCCAGTCACAGCCATACAGCTGTCCACACTGAAG AACATGTCCTACAACAGCCTGAATCAAATGGTTAGCTTAATAGATAAAAATCCCAGACTACTTCAGCCT TTAATGCCTTTTATTCATAAAAACTGTGAAAGCTAGACTGAACCATTGGAAACATTTAACTCAGACTCT GGATTCAGAGTCGGGAACCCTTAGTTCTATCTGAATCCAAGACAGCCACACCTTAGTATACTGCCCAAA CTAATGAGTTTAATAAATACAAATACTCGTTTCTTTTTGATTAGTGTGATTAGAACTGAACAACGGCAC TTAAGGAATCTGGAAGATAGCCTGGATAGATTTCTGATTCATCCCAAGACCTCAAAGACAACACCTGGG TACCAAATTTCTTTATTTGAAGGAATGGTACAAATCAAAGAACTTAAGTGGATGTTTTGGTACAACTTA TAGAAAAGGTAAAGGAAACCCCAACATGCATGCACTGCCTTGGTGACCAGGGAAGTCACCCCACGGCTA TGGGGAAATTAGCCCGAGGCTTAGCTTTCATTATCACTGTCTCCCAGGGTGTGCTTGTCAAAGAGATAT TCCGCCAAGCCAGATTCGGGCGCTCCCATCTTGCGCAAGTTGGTCACGTGGTCACCCAATTCTTTGATG GCTTTCACCTGCTCATTCAGGTAATGTGTCTCAATGAAGTCACACAACTGCAAAACAATGGGGAAGACA GTTAGTGGGCAGCTTTCCCAATCCCTAAGGCAAATGATTTCCTCCATTTATTTCCTGGGGTTCCAATAC TCACATGGGGGTCATTTTTGTCAGTGGCCAGTTTGTGCAGTTCCAGTAGTGACTGATTCACATTTTTTT CCAAATGTAATGCACACTCCATTGCATTCAGCCCGCTCTCCCAGTCATCACAGTCTGGTTTCTGAATG ACGCGTAAGCGGCCGCGGCATCTAGATTCGAAGAAAATGACCGACCAAGCGACGCCCAACCTGCCATCA CGAGATTTCGATTCCACCGCCGCCTTCTATGAAAGG
Restriction Sites	SgfI-MluI
OTI Disclaimer	Our molecular clone sequence data has been matched to the sequence identifier above as a point of reference. Note that the complete sequence of this clone is largely the same as the reference sequence but may contain minor differences , e.g., single nucleotide polymorphisms (SNPs).
Reference Data
RefSeq	NM_001139443.2
Synonyms	ARB; BEST; Best1V1Delta2; BMD; RP50; TU15B; VMD2
Summary	This gene encodes a member of the bestrophin gene family. This small gene family is characterized by proteins with a highly conserved N-terminus with four to six transmembrane domains. Bestrophins may form chloride ion channels or may regulate voltage-gated L-type calcium-ion channels. Bestrophins are generally believed to form calcium-activated chloride-ion channels in epithelial cells but they have also been shown to be highly permeable to bicarbonate ion transport in retinal tissue. Mutations in this gene are responsible for juvenile-onset vitelliform macular dystrophy (VMD2), also known as Best macular dystrophy, in addition to adult-onset vitelliform macular dystrophy (AVMD) and other retinopathies. Alternative splicing results in multiple variants encoding distinct isoforms.[provided by RefSeq, Nov 2008]
Locus ID	7439
MW	75.1

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